Streptokinase infusion for asparaginase-induced arterial thrombosis

Omar, Khairul Zaman; Ariffin, Hany; Abdullah, Wan Ariffin Bin; Chan, Lee-Lee; Lin, Hai

doi:10.1002/(sici)1096-911x(200005)34:5<377::aid-mpo16>3.0.co;2-8

Cited by 1 publication

(2 citation statements)

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“…It occurs due to genetic and environmental factors [9,12,13,29,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47]. The factors that cause trombosis during childhood are acquired factors such as cancer, catheterization, infections, immobilization, chemotherapy, and nephrotic syndrome [10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

“…In children with cancer, catheterization and using chemoterapy such as l-asparaginase and steroid treatment increase the thrombosis risk by 6.5 times [9]. The disproportionate reduction in natural anticoagulant levels, especially antithrombin III, protein C, and protein S, has been proposed as the pathogenic mechanism for the thromboetic complications associated with asparaginase [46,47]. In addition, corticosteroid treatment contributes to the risk of thrombosis by causing an increase in cholesterol and triglyceride levels [48].…”

Section: Discussionmentioning

confidence: 99%

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Granulomatous Reaction in Mediastinal B-Cell Non-Hodgkin Lymphoma and Intracardiac Thrombosis

Çorapçıoğlu

Başar

Demırel

et al. 2008

Pediatric Hematology and Oncology

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Epithelioid cell granulomas may be associated with several neoplasms. Lymphomas may mimic or are associated with epithelioid granulomas. In this article the authors report a child with granulomatous reaction in B cell non-Hodgkin lymphoma and intracardiac thrombosis. Although cancer alone is a risk factor for thromboembolism, thrombosis is a multifactorial disorder with both hereditary and acquired risk factors. This is the first reported case of intracardiac thrombosis with MTHFR A1298C and factor XIII V34L mutations together with granulomatous reaction in non-Hodgkin lymphoma.

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