Streptomyces: host for refactoring of diverse bioactive secondary metabolites

Abstract

Microbial secondary metabolites are intensively explored due to their demands in pharmaceutical, agricultural and food industries. Streptomyces are one of the largest sources of secondary metabolites having diverse applications. In particular, the abundance of secondary metabolites encoding biosynthetic gene clusters and presence of wobble position in Streptomyces strains make it potential candidate as a native or heterologous host for secondary metabolite production including several cryptic gene clusters expression. Here, we have discussed the developments in Streptomyces strains genome mining, its exploration as a suitable host and application of synthetic biology for refactoring genetic systems for developing chassis for enhanced as well as novel secondary metabolites with reduced genome and cleaned background.

Bioactive metabolites of Streptomyces misakiensis display broad-spectrum antimicrobial activity against multidrug-resistant bacteria and fungi

“…The search for new, effective antibiotics against MDR pathogens is the most vital issue for the treatment of infectious diseases. There has been increasing interest among researchers in screening novel bioactive secondary metabolites from Streptomyces species to overcome MDR pathogens (Sharma et al, 2021). Therefore, we aimed to test the antimicrobial activity of metabolite extracts of Representative photomicrographs of spleen sections of different groups in S. aureus mouse model.…”

Isolation, Characterization of Pyraclostrobin Derived from Soil Actinomycete Streptomyces sp. HSN-01 and Its Antimicrobial and Anticancer Activity

“…One of the largest sources of secondary metabolites is Streptomyces, producing antibiotics, herbicides, parasiticides, immunosuppressive agents, antitumor compounds, and other compounds of great pharmaceutical and industrial use [44]. As a model prokaryotic system, Streptomyces has a complex and multicellular lifecycle.…”

Streptomyces: The biofactory of secondary metabolites

“…Streptomyces- derived bioactive natural products have the capability to function as antimicrobial, antiviral, cytotoxic, antitumor, antihypertensive, immunosuppressive, insecticide, antioxidative, plant growth-promoting, and herbicidal agents ( Singh and Khajuria, 2018 ; Nguyen et al, 2020 ; Salwan and Sharma, 2020 ; Pham et al, 2021 ; Sharma et al, 2021 ). So, the discovered metabolites can be classified into four classes: (i) Compounds with regulatory activities include morphogenic agents, siderophores, and growth factors; (ii) anti-protozoans, antibacterials, antifungals, and antivirals as antagonistic agents; (iii) insecticides, pesticides, and herbicides as agrobiologicals; and (iv) neurological agents, immunomodulators, antitumor agents, and enzyme inhibitors as pharmacological drugs.…”