Streptomyces sudanensis sp. nov., a new pathogen isolated from patients with actinomycetoma

Quintana, Erika T.; Wierzbicka, Katarzyna; Mackiewicz, Paweł; Osman, Ahmed; Fahal, Ahmed H.; Hamid, Mohamed E.; Zakrzewska‐Czerwińska, Jolanta; Maldonado, Luis A.; Goodfellow, Michael

doi:10.1007/s10482-007-9205-z

Cited by 68 publications

(56 citation statements)

References 38 publications

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“…They can, however, be caused by S. somaliensis and S. sudanensis (497,498). The majority of invasive Streptomyces infections are associated with bacteremia and lung infections, namely, pneumonia, abscess, and pneumonitis (499).…”

Section: Interactions Between Actinobacteria and Vertebratesmentioning

confidence: 99%

Taxonomy, Physiology, and Natural Products of Actinobacteria

Barka

Vatsa

Sanchez

et al. 2016

Microbiol Mol Biol Rev

1,592

1,048

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SUMMARYActinobacteriaare Gram-positive bacteria with high G+C DNA content that constitute one of the largest bacterial phyla, and they are ubiquitously distributed in both aquatic and terrestrial ecosystems. ManyActinobacteriahave a mycelial lifestyle and undergo complex morphological differentiation. They also have an extensive secondary metabolism and produce about two-thirds of all naturally derived antibiotics in current clinical use, as well as many anticancer, anthelmintic, and antifungal compounds. Consequently, these bacteria are of major importance for biotechnology, medicine, and agriculture.Actinobacteriaplay diverse roles in their associations with various higher organisms, since their members have adopted different lifestyles, and the phylum includes pathogens (notably, species ofCorynebacterium,Mycobacterium,Nocardia,Propionibacterium, andTropheryma), soil inhabitants (e.g.,MicromonosporaandStreptomycesspecies), plant commensals (e.g.,Frankiaspp.), and gastrointestinal commensals (Bifidobacteriumspp.).Actinobacteriaalso play an important role as symbionts and as pathogens in plant-associated microbial communities. This review presents an update on the biology of this important bacterial phylum.

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Section: Interactions Between Actinobacteria and Vertebratesmentioning

confidence: 99%

Taxonomy, Physiology, and Natural Products of Actinobacteria

Barka

Vatsa

Sanchez

et al. 2016

Microbiol Mol Biol Rev

1,592

1,048

View full text Add to dashboard Cite

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“…Streptomyces is a representative of a filamentous bacteria responsible for producing variety of valuable secondary metabolites, such as antibiotics, parasiticides, herbicides, and pharmacologically active substances, including antitumor agents and immunosuppressants (Waksman and Woodruff, 1940;Ditsler et al, 1992;Euverink, 1995;Newman et al, 2000;El Hassan et al, 2001;Bentley et al, 2002;Bibb, 2005;Quintana et al, 2008;Li et al, 2009;Doroghazi et al, 2014). Genome sequencing analyses of Streptomyces avermitilis (Omura et al, 2001), Streptomyces coelicolor A3(2) (Bentley et al, 2002), Streptomyces griseus IFO 13350 (Ohnishi et al, 2008), and Streptomyces bingchenggensis (Wang et al, 2010) revealed that Streptomyces possess an unexpected abundance of natural product biosynthetic gene clusters and thus that they have the potential to make many more compounds than previously thought.…”

Section: Introductionmentioning

confidence: 99%

SECONDARY BIOACTIVE METABOLITE GENE CLUSTERS IDENTIFICATION OF ANTICANDIDA-PRODUCING Streptomyces Sp. GMR22 ISOLATED FROM WANAGAMA FOREST AS REVEALED BY GENOME MINING APPROACH

Herdini

Miceli

Hariwiyanto

et al. 2017

Indonesian J. Pharm.

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Streptomyces are a group of Gram-positive bacteria belonging to the Actinobacteria class, which are among the most important bacteria for producing secondary bioactive metabolites such as antibiotics, chemotherapeutics, insecticides and other high-value chemicals. Genome mining of gene clusters that encode the biosynthetic pathways for these metabolites has become a key methodology for novel compound discovery. Recently, we have isolated the Streptomyces sp. GMR22 from Cajuput rhizospheric soil at Wanagama Forest, Indonesia. GMR22 produced a secondary metabolite that inhibited Candida albicans with IC 50 of 62.5μg/mL. The objective of this work was to reveal the novel secondary metabolites from GMR22 by genome mining approach. The antiSMASH 3.0 was used to predict gene clusters that encode the biosynthetic pathways of secondary metabolites in the genome of GMR22, and their core chemical structures. The phylogenomic analysis showed that GMR22 was closely related to Streptomyces bingchenggensis BCW1, as well as to the large genome size (9.5-12.7Mbp) groups of Streptomyces. AntiSMASH 3.0 analysis revealed that the genome of Streptomyces sp. GMR22 harbored at least 63 gene clusters that encode the biosynthetic pathways of secondary metabolites. It was the highest number of gene clusters had been observed among the members of Streptomyces groups, with polyketide synthetase (PKS) was predicted as the major groups of the identified gene cluster products. The results suggested that GMR22 could be a strong potential candidate for secondary bioactive metabolites source.

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“…treptomyces somaliensis is a Gram-positive, aerobic, filamentous human-pathogenic actinomycete that is a significant cause of actinomycetoma (4,9). Actinomycetomas are severe and debilitating infections that can spread to affect deep tissue and bone and are characterized by the formation of tissue masses, which may result in tissue destruction and deformity and may be fatal without surgical intervention.…”

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confidence: 99%