Streptomycin

Nichols, Donald R.

doi:10.1001/jama.1946.02870390016004

Cited by 40 publications

(2 citation statements)

References 21 publications

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“…Earlier reports from the U.S.A. (Reimann et al, 1945; Report, 1946;Nichols and Herrell, 1946), all based on the treatment of a substantial number of patients, usually with full doses given for what should be an adequate period, are unanimous in their disappointment with the results. Some patients have not appeared to respond in any way, fever continuing and blood culture remaining positive even during the course; others have improved temporarily, but few have apparently been cured.…”

Section: Neurosismentioning

confidence: 99%

“…Such in vitro findings accurately reflect the therapeutic capacity of penicillin, but in connexion with streptomycin they are sometimes misleading, and the two principal diseases which have not responded to streptomycin treatment in accordance with expectation on, these grounds are typhoid fever and undulant fever. Earlier reports from the U.S.A. (Reimann et al, 1945;Report, 1946;Nichols and Herrell, 1946), all based on the treatment of a substantial number of patients, usually with full doses given for what should be an adequate period, are unanimous in their disappointment with the results. Some patients have not appeared to respond in any way, fever continuing and blood culture remaining positive even during the course; others have improved temporarily, but few have apparently been cured.…”

Section: Neurosismentioning

confidence: 99%

See 1 more Smart Citation

Streptomycin-Sulphadiazine Treatment of Undulant Fever

Scowen¹,

Garrod²

1948

BMJ

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DEc. 25, 1948 RESULTS OF PARTIAL GASTRECTOMY BRrrnSH 1099 MEDICAL JOIJRNAL that a few times in the year two patients listed under " fair-" results have had attacks that are suggestive of hypoglycaemia, and their glucose-tolerance curves, though not conclusive, lend support to this belief. Apart from this there is nothing to suggest that hypoglycaemia is either a frequent or a troublesome factor in producing postcibal distress, and we find nothing to support Gilbert and Dunlop's (1947) view that it is the essential cause of that distress. In this series the symptoms usually begin during or shortly after a meal, at a time when the blood-sugar curve is high. In addition the symptoms are exacerbated, not alleviated. by taking meals with a high fat content. NeurosisWe have been loath to attribute post-gastrectomy symptoms to neurosis, though there is some evidence of this in Cases 4 and 6. While under observation in the ward they did not complain of postcibal distress, nor did they show the objective phenomena, such as sweating, which are associated with this condition. They probably have occasional symptoms. These two patients come under the ill-defined heading of the " dumping " stomach, but both are in receipt of a pension on account of their gastric disability, which may well be a factor in their symptomatology.There is one other patient (Case 3) whose chief postoperative symptom is backache. Neither his symptoms nor investigations suggest that his alimentary tract is the cause of the trouble. Conclusions The review of this series has brought out the following points:That the operation of partial gastrectomy for simple ulcer carries a reasonably low mortality. In this series it was 2%.That in the main the patients who have had a partial gastrectomy for ulcer are satisfied. 73 % are symptom-free and 22% have slight symptoms which are not severe enough to make them dissatisfied.Approximately 5% either have a poor functional result or are dissatisfied. Investigation of this group is worth while;in some cases faults due to the technique of the operation are disclosed and can be remedied. Intercurrent disease may be the cause in other cases. That the more troublesome and chronic the original ulcer the more tolerant is the patient of minor functional disturbances in his post-gastrectomy result.With the exception of anastomosis of the afferent loop to the greater curve, which leads to a high incidence of proximalloop filling, there is nothing to choose between the functional results of the other three anastomoses employed.The long proximal loop needed in the antecolic operation is more likely to lead to complications than the short loop used in the retrocolic operation. The Billroth I anastomosis is probably the safest of all, as it has no afferent loop. Owing to the risk of stenosis this is not a suitable anastomosis after gastrectomy for duodenal ulcer.That When two chemotherapeutic agents of partial efficacy are available it is likely that they will have an additive if not a synergic effect when administered t...

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Section: Neurosismentioning

confidence: 99%

Section: Neurosismentioning

confidence: 99%