Streptomycin-Induced Defects of the Otocon1al Membrane

Johnsson, Lars Göran; Wright, Charles G.; Preston, Robert E.; Henry, Pamela J.

doi:10.3109/00016488009127155

Cited by 35 publications

(20 citation statements)

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“…Several alleles of the mouse mutant Ames waltzer have mutations in Protocadherin 15 and lose their sensory epithelium as they age. The otoconia in these mutants degenerate in a similar time course as the loss of the epithelium, though fragments of the gelatinous membrane can still be present (Johnsson et al, 1980;Takumida et al, 1997a,b;Yamane et al, 1984). Young Ames waltzer mice have no obvious defects in vestibular structure (Alagramam et al, 2005), suggesting degeneration, as opposed to altered development, as the cause of otoconial loss.…”

Section: Maintenance Of Otoconiamentioning

confidence: 99%

“…An increased percentage of abnormal otoconia or a reduction in number has been observed in humans and/or experimental animals following treatment with inhibitors of carbonic anhydrase, prostaglandins, and secondary to intoxication with ethacrynic acid, dilantin, or the aminoglycoside antibiotics streptomycin, neomycin, or gentamicin (Harada and Sugimoto, 1977;Johnsson et al, 1980;Lim, 1984;Minck et al, 1989;Takumida et al, 1997a;Wright et al, 1979. The majority of these pharmacological agents are believed to lead to significant alterations in the pH of the endolymph (carbonic anhydrase inhibitors) through damage to vestibular dark cells or the death of vestibular hair cells.…”

Section: Maintenance Of Otoconiamentioning

confidence: 99%

“…Aminoglycosides cause destruction of otoconia and increase the likelihood of otoconiaassociated vestibular dysfunction through both hair cell destruction and disruption of endolymph ionic content. Direct treatment of isolated otoconia with high dose aminoglycosides does not appear to alter the surface of otoconia (M. Warchol, unpublished data), but treatment of the inner ear with streptomycin or gentamicin leads to otoconia degeneration, the timing and distribution of which coincide with hair cell degeneration (Johnsson et al, 1980;Takumida et al, 1997a). In addition, streptomycin has been shown to disrupt the activity of cells in the vestibular dark epithelium that are responsible for the maintenance of the endolymphatic ion content (Fujii et al, 1995;Harada and Sugimoto, 1977;Yamane et al, 1984).…”

Section: Maintenance Of Otoconiamentioning

confidence: 99%

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Mixing model systems: Using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development

Hughes

Thalmann

et al. 2006

Brain Research

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Human vestibular dysfunction is an increasing clinical problem. Degeneration or displacement of otoconia is a significant etiology of age-related balance disorders and Benign Positional Vertigo (BPV). In addition, commonly used antibiotics, such as aminoglycoside antibiotics, can lead to disruption of otoconial structure and function. Despite such clinical significance, relatively little information has been compiled about the development and maintenance of otoconia in humans. Recent studies in model organisms and other mammalian organ systems have revealed some of the proteins and processes required for the normal biomineralization of otoconia and otoliths in the inner ear of vertebrates. Orchestration of extracellular biomineralization requires bringing together ionic and proteinaceous components in time and space. Coordination of these events requires the normal formation of the otocyst and sensory maculae, specific secretion and localization of extracellular matrix proteins, as well as tight regulation of the endolymph ionic environment. Disruption of any of these processes can lead to the formation of abnormally shaped, or ectopic, otoconia, or otoconial agenesis. We propose that normal generation of otoconia requires a complex temporal and spatial control of developmental and biochemical events. In this review, we suggest a new hypothetical model for normal otoconial and otolith formation based on matrix vesicle mineralization in bone which we believe to be supported by information from existing mutants, morphants, and biochemical studies.

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Section: Maintenance Of Otoconiamentioning

confidence: 99%

Section: Maintenance Of Otoconiamentioning

confidence: 99%

Section: Maintenance Of Otoconiamentioning

confidence: 99%

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Mixing model systems: Using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development

Hughes

Thalmann

et al. 2006

Brain Research

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“…Gentamicin (GM) is an aminoglycoside antibiotic, which is effective against gram-negative bacterial infection [7] . GM ototoxicity is a common cause of drug-induced hearing loss [8] . Recently, clinical evidence revealed that the degree of GM-induced vestibular damage to the semicircular canal ampullae, saccule, and utricle varied among patients [9,10] .…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Ginkgo Biloba Extract on Gentamicin-Induced Structural Changes of Calcite-Gelatin Composite

Jang

Cho²,

Lee³

2016

Int Adv Otol

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OBJECTIVE:To evaluate the protective effect of Ginkgo biloba extract (GBE) on gentamicin (GM)-induced morphological damage of an artificial otoconia. MATERIALS and METHODS:An artificial otoconia powder was placed in a 12-well culture plate containing artificial endolymph. GM (500 μL; 40 mg/mL) was added to the first four wells. GM (500 μL; 40 mg/mL) with GBE (500 μL) was added to the next four wells. PBS (500 μL) was added to the remaining four wells as a control. The levels of nitric oxide (NO) synthesis were determined in the supernatants of each group. Alteration in surface morphology and calcium content were determined by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX), respectively. RESULTS:NO concentration increased in the GM-treated group compared with that in the control group. When the calcite-gelatin composite was treated with GBE, GM-stimulated NO production significantly decreased. The surface of the calcite-gelatin composite exposed to GM showed erosive fissures and had a honeycomb-like appearance. GBE showed a protective effect against dissolution. EDX showed that the calcium content of the GM-treated group significantly decreased. However, the GBE-treated group demonstrated an insignificant change in the calcium concentration compared with the control. CONCLUSION:From these results, we can conclude that GBE may have a protective effect against GM-induced NO production and superficial structural changes.

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“…Basel 0301-1569/9 7/0595-026 3S12.00/0 E-Mail karger@karger.ch F ax+ 41 61 306 12 34 ht t p:// w\vw. karger, ch while gentamicin created more generalized loss of saccu lar otoconia with some giant otoconia remaining [12], In addition, loss of otoconia in both saccular and utricular macula has been observed in guinea pigs after the admin istration of streptomycin (SM) [12,13], The present study was designed to obtain more com plete knowledge of the effects of SM on the otoconial layer, in order to clarify the degeneration and recovery as well as the regional differences between in the utricle and saccule.…”

Section: Introductionmentioning

confidence: 99%

Effect of Streptomycin on the Otoconial Layer of the Guinea Pig

Takumida

Zhang²,

Yajin³

et al. 1997

ORL

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The effects of streptomycin on the otoconial layer of the adult guinea pig were investigated using scanning electron microscopy. Administration of streptomycin induced a reduction of otoconia with formation of giant otoconia. These phenomena reached their maximum 4 weeks after the cessation of streptomycin intoxication in the utricle and between 2 and 6 weeks after in the saccule. Otoconia began to recover in the utricle 4 weeks and in the saccule 6 weeks after the cessation of streptomycin intoxication with an increasing number of small otoconia. Eight or 10 weeks after the cessation of streptomycin intoxication, the otoconial layer has completely recovered in both the utricle and saccule.

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Streptomycin-Induced Defects of the Otocon1al Membrane

Cited by 35 publications

References 9 publications

Mixing model systems: Using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development

Mixing model systems: Using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development

Protective Effect of Ginkgo Biloba Extract on Gentamicin-Induced Structural Changes of Calcite-Gelatin Composite

Effect of Streptomycin on the Otoconial Layer of the Guinea Pig

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