Inpatient nurses have the ability and qualified knoledge in treating patients. Nurses often experience work stress due to caring for patient with various diseases, facing work situations and pressure at work. This research aims to determine the relationship betwenn work stress levels and sleep quality in inpatient nurses. This type of quantitative research with a correlational mwthod using a cross sectional approach. The sample in this study were nurses in the alamanda and mawar inpatient rooms. The sampling technoque used simple random sampling technique with a sample of 36 respondents with 18 respondents in each room. The bivariate test uses the rank speread test with research instruments in the form of standardized questionnaires, namely HSE and PSQI. In this study, it has gone through an ethical test with number 60/EC-LPPM/UWHS/VII-2023. The results showed that 22 respondents (61,1%) had moderate levels of work stress and 21 respondents (58,3%) has poor sleep quality. The result is a p value of 0,044