Quarantine and isolation caused by COVID-19 pandemic revealed a new stress condition in marriage relationship. This study aimed to investigate, under quarantine and isolation days, how relational resilience in marriage is explained with their psychological distress, and mediation roles of negative and positive dyadic coping in the marriage relationship between psychological distress and relational resilience. Data of the research study was obtained via an online form two months after the announcement of the pandemic in Turkey. The participants were 386 married people (49.7% were men, 50.3% women) who ranged in age from 23 to 65 years (M = 37.35, SD = 10.10). Participants were given Personal Information Form, The Relational Resilience Scale, The Dyadic Coping Inventory, Kessler Psychological Distress Scale, and Intolerance of Uncertainty Scale. Results showed that negative and positive coping have mediating influence on psychological stress of married individuals and their relational resilience during quarantine. It is seen that especially in quarantine days, positive coping strategies of married individuals, in coping with these conditions, is an important factor increasing relational resilience.