Stress affects dopaminergic signaling pathways in<i>Drosophila melanogaster</i>

Neckameyer, Wendi S.; Weinstein, Joshua S

doi:10.1080/10253890500147381

Cited by 65 publications

(47 citation statements)

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“…We found that in F. japonica, DA levels in foraging worker brains decreased under starvation, as previously shown for 5-day-oldfemale Drosophila melanogaster (Neckameyer and Weinstein, 2005). In mice, the dopaminergic circuitry is involved in feeding, and disrupting dopamine signaling decreased motivation for eating and drinking (Narayanan et al, 2010).…”

Section: Discussionsupporting

confidence: 61%

“…Conversely, starvation stress did not affect OA levels and there was no relationship between OA and trophallaxis in the starved ants. Yet, it is well known that various stressors such as high/low temperature and high population density affect OA level in insects (Woodring et al, 1988;Rauschenbach et al, 1993;Gruntenko et al, 2004;Neckameyer and Weinstein, 2005;Chen et al, 2008). We demonstrated a slight effect of starvation on OA level and thus there may be a role for OA in starvation stress and social behavior in F. japonica.…”

Section: Discussionmentioning

confidence: 64%

“…Also, administration of OA changed the duration of trophallaxis in socially deprived C. fellah workers (Boulay et al, 2000a;Boulay et al, 2000b). Additionally, it is well known that stress, resulting from temperature, mechanical or chemical stimuli, population density and starvation, modulates biogenic amine levels in the insect brain (Chen et al, 2008;Gruntenko et al, 2004;Rauschenbach et al, 1993;Woodring et al, 1988;Neckameyer and Weinstein, 2005). However, the relationship between brain biogenic amines and social behaviors in ants remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Social interactions influence dopamine and octopamine homeostasis in the brain of the ant Formica japonica

Wada‐Katsumata

Yamaoka

Aonuma

2011

Journal of Experimental Biology

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SUMMARYIn ants, including Formica japonica, trophallaxis and grooming are typical social behaviors shared among nestmates. After depriving ants of either food or nestmates and then providing them with either food or nestmates, a behavioral change in type and frequency of social interactions was observed. We hypothesized that starvation and isolation affected levels of brain biogenic amines including dopamine (DA) and octopamine (OA) -neuromediators modifying various insect behaviors -and tested the relationship between brain biogenic amines and social behaviors of stressed ants. Ants starved for 7days contained lower brain DA levels and they did not perform trophallaxis toward nestmates. Feeding starved ants sucrose solution re-established trophallaxis but not brain DA levels. The performance of trophallaxis induced recovery of brain DA content to the level of untreated ants. Ants that were isolated for 2days displayed markedly increased OA levels, which following nestmate interactions, returned to levels similar to those of control (non-isolated) ants and ants isolated for 1h. We conclude that: (1) starvation reduced brain DA level but had no significant effect on brain OA (trophallaxis recovered the brain DA levels), and (2) isolation increased brain OA level but had no effect on brain DA (trophallaxis and grooming events recovered the brain OA levels). We suggest that social interactions with nestmates influenced brain biogenic amine homeostasis in stressed F. japonica.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 64%

Section: Introductionmentioning

confidence: 99%

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Social interactions influence dopamine and octopamine homeostasis in the brain of the ant Formica japonica

Wada‐Katsumata

Yamaoka

Aonuma

2011

Journal of Experimental Biology

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“…Drosophila tyrosine hydroxylase is encoded by the pale locus (51), and mutations in the pale gene result in decreased dopamine pools in adult heads, even in the heterozygous state (22). Compared with wild type, ple mutants showed increased susceptibility toward various types of stress, including the dopaminergic toxicant paraquat, indicating that dopamine functions as a key element in the stress response (22,52). Here we also found that 1-octen-3-ol was more toxic in the ple heterozygous mutant lines.…”

Section: Discussionmentioning

confidence: 99%

Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

Inamdar

Hossain

Bernstein

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Parkinson disease (PD) is the most common movement disorder and, although the exact causes are unknown, recent epidemiological and experimental studies indicate that several environmental agents may be significant risk factors. To date, these suspected environmental risk factors have been man-made chemicals. In this report, we demonstrate via genetic, biochemical, and immunological studies that the common volatile fungal semiochemical 1-octen-3-ol reduces dopamine levels and causes dopamine neuron degeneration in Drosophila melanogaster. Overexpression of the vesicular monoamine transporter (VMAT) rescued the dopamine toxicity and neurodegeneration, whereas mutations decreasing VMAT and tyrosine hydroxylase exacerbated toxicity. Furthermore, 1-octen-3-ol also inhibited uptake of dopamine in human cell lines expressing the human plasma membrane dopamine transporter (DAT) and human VMAT ortholog, VMAT2. These data demonstrate that 1-octen-3-ol exerts toxicity via disruption of dopamine homeostasis and may represent a naturally occurring environmental agent involved in parkinsonism.building-related illness | mold | mushroom alcohol

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“…In Drosophila, molecular-genetic and pharmacologic analyses have demonstrated the importance of DA in sleep, arousal, light perception, circadian entrainment, feeding, and aversive conditioning (Schwaerzel et al 2003;Andretic et al 2005;Kume et al 2005;Neckameyer and Weinstein 2005;Chang et al 2006;Draper et al 2007;Bayersdorfer et al 2010;Hirsh et al 2010;Riemensperger et al 2011); of 5-HT in aggression, place memory, circadian rhythms, and sleep (Yuan et al 2005(Yuan et al , 2006Sitaraman et al 2008;Alekseyenko et al 2010); and of OA in sleep, locomotion, female fertility, aggression, place memory, and the fly's response to environmental stressors (Hirashima et al 2000;Lee et al 2003;Fox et al 2006;Hardie et al 2007;Crocker and Sehgal 2008;Zhou et al 2008;Crocker et al 2010;Sitaraman et al 2010). However, as in mammals, the relative importance of each aminergic system for particular behaviors and their potential interplay remain unclear.…”

mentioning

confidence: 99%

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

Chen

Lebestky

et al. 2013

Genetics

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To investigate the regulation of Drosophila melanogaster behavior by biogenic amines, we have exploited the broad requirement of the vesicular monoamine transporter (VMAT) for the vesicular storage and exocytotic release of all monoamine neurotransmitters. We used the Drosophila VMAT (dVMAT) null mutant to globally ablate exocytotic amine release and then restored DVMAT activity in either individual or multiple aminergic systems, using transgenic rescue techniques. We find that larval survival, larval locomotion, and female fertility rely predominantly on octopaminergic circuits with little apparent input from the vesicular release of serotonin or dopamine. In contrast, male courtship and fertility can be rescued by expressing DVMAT in octopaminergic or dopaminergic neurons, suggesting potentially redundant circuits. Rescue of major aspects of adult locomotion and startle behavior required octopamine, but a complementary role was observed for serotonin. Interestingly, adult circadian behavior could not be rescued by expression of DVMAT in a single subtype of aminergic neurons, but required at least two systems, suggesting the possibility of unexpected cooperative interactions. Further experiments using this model will help determine how multiple aminergic systems may contribute to the regulation of other behaviors. Our data also highlight potential differences between behaviors regulated by standard exocytotic release and those regulated by other mechanisms. BOTH invertebrate and mammalian behaviors undergo extensive regulation by monoamine neurotransmitters (reviewed in Joshua et al.

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Stress affects dopaminergic signaling pathways inDrosophila melanogaster

Cited by 65 publications

References 45 publications

Social interactions influence dopamine and octopamine homeostasis in the brain of the ant Formica japonica

Social interactions influence dopamine and octopamine homeostasis in the brain of the ant Formica japonica

Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

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