Stress, Age, and Immune Function: Toward a Lifespan Approach

Graham, Jennifer E.; Christian, Lisa M.; Kiecolt‐Glaser, Janice K.

doi:10.1007/s10865-006-9057-4

Cited by 284 publications

(215 citation statements)

References 120 publications

(132 reference statements)

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“…32,33 In one such study, chronically stressed men and women caring for spouses with dementia showed a four-fold increase in interleukin-6 production compared with noncare partners. Those with the greatest interleukin-6 levels had a two-fold increased risk of death in the next 4 to 5 years compared with those with the lowest levels.…”

Section: Care Partner Socioeconomic Burdenmentioning

confidence: 99%

Care Partners and Multiple Sclerosis

Mckenzie

Quig

Tyry

et al. 2015

International Journal of MS Care

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Background: Caring for someone with multiple sclerosis (MS) can be a stressful experience that requires clinical attention. We investigated the impact of caregiver stress on the emotional well-being and physical health of the MS care partner using the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry. Methods: Care partners of NARCOMS participants were invited to complete an online questionnaire that captured demographic characteristics, health status, caregiver burden as measured by the Zarit Caregiver Burden Interview, and impact of caregiving on employment. Results: Of 1446 care partners who agreed to participate, 1333 had complete data. Most were men (n = 825, 61.9%), with a mean (SD) age of 51.1 (11.2) years. The mean (SD) Zarit total score was 24.6 (15.1), placing the overall group in the mild caregiver burden range. Compared with male care partners, female care partners reported higher levels of burden and stress and more medication use for stress/anxiety and mood disorders. Male care partners were more likely to report physical concerns. Care partners of people with primary progressive MS reported greater perceived burden than did partners of people with secondary progressive MS and relapsing-remitting MS. More than 40% of care partners (559 of 1288) had missed work during the past year owing to caregiving responsibilities. Conclusions: Care partners of people with MS have substantial physical and psychological health concerns and experience an adverse impact on employment. Future research should evaluate how to mitigate the adverse effects of caregiving and evaluate positive aspects of the role.

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Section: Care Partner Socioeconomic Burdenmentioning

confidence: 99%

Care Partners and Multiple Sclerosis

Mckenzie

Quig

Tyry

et al. 2015

International Journal of MS Care

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“…The way ageing and stress simultaneously act to affect the immune response seems to be influenced not only by the way organisms age, but it could be highly influenced also by early life event experience (Graham et al 2006). Long-term effects seem to emerge not only after negative maternal behaviours, such as poor prenatal nutrition, but also following external, psychological and environmental stress in mothers (reviewed in Graham et al 2006).…”

Section: Ageing Stress and The Immune Systemmentioning

confidence: 99%

Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system

Vitlić

Lord

Phillips

2014

AGE

103

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The immune response is essential for keeping an organism healthy and for defending it from different types of pathogens. It is a complex system that consists of a large number of components performing different functions. The adequate and controlled interaction between these components is necessary for a robust and strong immune response. There are, however, many factors that interfere with the way the immune response functions. Stress and ageing now consistently appear in the literature as factors that act upon the immune system in the way that is often damaging. This review focuses on the role of stress and ageing in altering the robustness of the immune response first separately, and then simultaneously, discussing the effects that emerge from their interplay. The special focus is on the psychological stress and the impact that it has at different levels, from the whole system to the individual molecules, resulting in consequences for physical health.

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“…Finally, previous research has shown that older adults and stressed persons have parallel changes in an overall decline in health (Graham, Christian, & Kiecolt-Glaser, 2006).…”

Section: Stress Across the Lifespanmentioning

confidence: 83%

“…Also consistent with previous research, older adults experience stress over their general decline in health (Aldwin, 2007). This may result from older adults who experience an increased risk for life-threatening illness (Castle, 2000;Graham et al, 2006). Further, there are parallel changes that older adults have with stressed individuals, such as immune dysregulation (Graham et al, 2006).…”

Section: Stress Across the Lifespanmentioning

confidence: 99%

“…This may result from older adults who experience an increased risk for life-threatening illness (Castle, 2000;Graham et al, 2006). Further, there are parallel changes that older adults have with stressed individuals, such as immune dysregulation (Graham et al, 2006). Thus, the effects that stress have on health are particulary important for older rather than younger adults.…”

Section: Stress Across the Lifespanmentioning

confidence: 99%

See 1 more Smart Citation

Social relationships and personal control: Factors that influence stress across the lifespan

Mendiola¹,

Cotter²

2011

PsycEXTRA Dataset

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Dateiii Student: Jennifer A. Mendiola I certify that this student has met the requirements for format contained in the University format manual, and that this thesis is suitable for shelving in the Library and credit is to be awarded for the thesis. Stress has negative consequences for well-being across the lifespan. Thus, social support, social strain, and control beliefs were examined in undergraduates and seniors (N = 364, ages 18 to 97, 72% women) for their relationships to multiple domains of stress.Hierarchical regression analyses controlling for demographics revealed that social strain was associated with partner (β = .26, p < .001), family (β = .29, p < .001), and friend (β = .27, p < .001) stress and perceived constraints were associated with financial (β = .26, p < .001), health (β = .33, p < .001), and work (β = .15, p = .017) stress, whereas social support (β = -.17, p = .006) was only associated with partner stress and mastery was associated with no domains of stress. Results suggest the importance of reducing social strain and minimizing constraints across the lifespan.

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Stress, Age, and Immune Function: Toward a Lifespan Approach

Cited by 284 publications

References 120 publications

Care Partners and Multiple Sclerosis

Care Partners and Multiple Sclerosis

Stress, ageing and their influence on functional, cellular and molecular aspects of the immune system

Social relationships and personal control: Factors that influence stress across the lifespan

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