High-temperature superconductors are anisotropic materials and are often subjected to variable external magnetic and temperature fields. The non-uniformity of excitation environment and material will lead to the increase of AC loss and change of magnetostriction effect of superconducting material, which will result in unstable operation and even fracture damage of the equipment. In this paper, cylindrical high-temperature superconductors with material anisotropy are placed in a periodic alternating magnetic field. By controlling the amplitude of external magnetic field, excitation frequency, and non-uniform coefficient of material elastic modulus and ambient temperature, the distribution of electromagnetic field, temperature field, and magnetization intensity during the magnetization of superconductors has been investigated in depth. The AC loss and magnetostriction with the external field loading and unloading process are also discussed in detail based on the electro-magnetic-thermal coupling effect. The results demonstrate that variations in the amplitude and excitation frequency of the external magnetic field will have a remarkable effect on the trapped field, AC loss, and magnetostriction of the superconductor. The change in the non-uniformity coefficient of the material's elastic modulus only has a greater effect on magnetostriction, but has no significant changes on the trapped field, magnetic moment distribution, and AC loss.