Stress and conflict conditions leading to and maintaining voluntary alcohol consumption in rats

Caplan, Marjorie; Puglisi, Kathleen

doi:10.1016/0091-3057(86)90350-3

Cited by 51 publications

(15 citation statements)

References 22 publications

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“…From another perspective, Volpicelli et al (1982) observed that whereas ethanol drinking decreased during a stressful period, ethanol drinking sometimes increased following stress. Similar increases were observed when the ethanol was provided in an environment apart from the stress (Caplan and Puglisi 1986), or when the stress was unpredictable (Nash and Maickel 1985). Such increased ethanol drinking during post-stress intervals, and presumably following CRF activation, may be secondary to CRF-induced elevations of adrenal glucocorticoid plasma levels.…”

Section: Tension Reduction Hypothesis Of Alcoholismsupporting

confidence: 68%

Effects of third intracerebroventricular injections of corticotropin- releasing factor (CRF) on ethanol drinking and food intake

et al. 1998

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Corticotropin releasing factor (CRF), a neuropeptide secreted by hypothalamic and extrahypothalamic neurons, is thought to mediate stress-related behaviors. The tension reduction hypothesis suggests that ethanol drinking reduces stress; that drinking is reinforced by this reduced stress; and that the probability of drinking therefore subsequently increases. CRF also decrease food intake, and might decrease ethanol drinking similarly. We addressed these hypotheses directly by assessing the effects of intracerebroventricular (i.c.v.) CRF upon ethanol drinking (1 h/day). Rats were provided drinking tubes containing ethanol solutions that were gradually incremented in concentration (from 2% to 8% w/v, over 38 days). Ethanol intakes remained stable, ranging from 0.4 to 0.5 g/kg per hour on average, and a two-bottle choice test revealed that ethanol was preferred reliably to water. Third-i.c.v. cannulae were surgically implanted and CRF or vehicle was acutely injected immediately prior to the sessions. CRF dose-dependently reduced ethanol intake by 31% (0.5 microg) and 64% (5.0 microg), and reduced 24-h food by 9% and 21%, respectively, but did not alter body weights. I.c.v. CRF reduced ethanol drinking despite any acute stress-like effects that may have been present. Hence, these data are inconsistent with the tension reduction hypothesis. On the other hand, our results support the concept that food intake and ethanol drinking may be mediated by similar mechanisms.

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Section: Tension Reduction Hypothesis Of Alcoholismsupporting

confidence: 68%

Effects of third intracerebroventricular injections of corticotropin- releasing factor (CRF) on ethanol drinking and food intake

et al. 1998

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“…Similarly, exposure to nociceptive stress in rodents has been found to increase, decrease, or have no effect on ethanol intake. For instance, rats and mice given unavoidable shocks, consumed greater amounts of ethanol solution [72][73][74]. In addition, stress history, increased ethanol intake in reinstatement after extinction [75].…”

Section: Discussionmentioning

confidence: 98%

Nucleus accumbens lentiviral-mediated gain of function of the oxytocin receptor regulates anxiety- and ethanol-related behaviors in adult mice

Bahí

Mansouri

Maamari

2016

Physiology & Behavior

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“…There have been multiple proposed hypotheses as to why models of acute/sub-chronic stress exposure do not always increase alcohol intake, and many of these revolve around specific experimental parameters that are thought to favor a particular outcome. These include, but are not limited to, the context in which the stressor is experienced in relation to drinking access (Caplan and Puglisi 1986; Volpicelli et al 1982), controllability of the stressor (Volpicelli and Ulm 1990), and whether the stressor is signaled or unsignalled (Kinney and Schmidt 1979). While there may be general trends in the influence of these variables on stress-induced changes in alcohol consumption, there are exceptions in nearly every case, and these observations may no longer remain true when considering different species, strains, or stressors.…”

Section: Acute/sub-chronic Stress Exposure During Alcohol Accessmentioning

confidence: 99%

Effects of stress on alcohol drinking: a review of animal studies

López²,

2011

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Rationale While stress is often proposed to play a significant role in influencing alcohol consumption, the relationship between stress and alcohol is complex and poorly understood. Over several decades, stress effects on alcohol drinking have been studied using a variety of animal models and experimental procedures, yet this large body of literature has generally produced equivocal results. Objectives This paper reviews results from animal studies in which alcohol consumption is evaluated under conditions of acute/sub-chronic stress exposure or models of chronic stress exposure. Evidence also is presented indicating that chronic intermittent alcohol exposure serves as a stressor that consequently influences drinking. Results The effects of various acute/sub-chronic stress procedures on alcohol consumption have generally been mixed, but most study outcomes suggest either no effect or decreased alcohol consumption. In contrast, most studies indicate that chronic stress, especially when administered early in development, results in elevated drinking later in adulthood. Chronic alcohol exposure constitutes a potent stressor itself, and models of chronic intermittent alcohol exposure reliably produce escalation of voluntary alcohol consumption. Conclusions A complex and dynamic interplay among a wide array of genetic, biological, and environmental factors govern stress responses, regulation of alcohol drinking, and the circumstances in which stress modulates alcohol consumption. Suggestions for future directions and new approaches are presented that may aid in developing more sensitive and valid animal models that not only better mimic the clinical situation, but also provide greater understanding of mechanisms that underlie the complexity of stress effects on alcohol drinking.

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Stress and conflict conditions leading to and maintaining voluntary alcohol consumption in rats

Cited by 51 publications

References 22 publications

Effects of third intracerebroventricular injections of corticotropin- releasing factor (CRF) on ethanol drinking and food intake

Effects of third intracerebroventricular injections of corticotropin- releasing factor (CRF) on ethanol drinking and food intake

Nucleus accumbens lentiviral-mediated gain of function of the oxytocin receptor regulates anxiety- and ethanol-related behaviors in adult mice

Effects of stress on alcohol drinking: a review of animal studies

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