Stress and cortisol in Parkinson's disease

Wamelen, Daniel J. van; Wan, Yi Min; Jenner, Peter

doi:10.1016/bs.irn.2020.01.005

Cited by 26 publications

(24 citation statements)

References 119 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Social isolation and its impact on PD are a concern and has been called a "hidden sorrow" of the pandemic 164 . Social isolation may cause heightened anxiety, aggravation of pre-existing depression, the negative effects of stress on PD 165 , as well as lack of exercise. In the previous SARS and MERS epidemics, one in three hospitalized cases went on to develop a PTSD with 15% developing depression and anxiety at 1 year, and fatigue in more than 15% 38 .…”

Section: The Clinical Perspectivementioning

confidence: 99%

COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside

Sulzer

Antonini

Leta

et al. 2020

npj Parkinsons Dis.

Self Cite

149

165

View full text Add to dashboard Cite

This Viewpoint discusses insights from basic science and clinical perspectives on coronavirus disease 2019 (COVID-19)/severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection in the brain, with a particular focus on Parkinson's disease. Major points include that neuropathology studies have not answered the central issue of whether the virus enters central nervous system neurons, astrocytes or microglia, and the brain vascular cell types that express virus have not yet been identified. Currently, there is no clear evidence for human neuronal or astrocyte expression of angiotensin-converting enzyme 2 (ACE2), the major receptor for viral entry, but ACE2 expression may be activated by inflammation, and a comparison of healthy and infected brains is important. In contrast to the 1918 influenza pandemic and avian flu, reports of encephalopathy in COVID-19 have been slow to emerge, and there are so far no documented reports of parkinsonism apart from a single case report. We recommend consensus guidelines for the clinical treatment of Parkinson's patients with COVID-19. While a role for the virus in causing or exacerbating Parkinson's disease appears unlikely at this time, aggravation of specific motor and non-motor symptoms has been reported, and it will be important to monitor subjects after recovery, particularly for those with persisting hyposmia.

show abstract

Section: The Clinical Perspectivementioning

confidence: 99%

COVID-19 and possible links with Parkinson’s disease and parkinsonism: from bench to bedside

Sulzer

Antonini

Leta

et al. 2020

npj Parkinsons Dis.

Self Cite

149

165

View full text Add to dashboard Cite

show abstract

“…Recently, it was discovered that multifactorial aspects of PD aetiology including aging, malnutrition, and stress were the strongest risk factors related to prodromal mechanisms associated with a disturbed hypothalamic-pituitary-adrenal (HPA) axis and high levels of P-cortisol [ 5 ]. However, whether this mechanism is correlated to the previously described increased risk for sarcopenia with age and malnutrition in patients with PD needs to be determined.…”

Section: Discussionmentioning

confidence: 99%

“…To increase understanding of mechanisms behind changes in anthropometry and functional decline, it is important to highlight the influence from stress and cortisol levels [ 5 ] and to consider the difference between males and females [ 2 ]. Glucocorticoids have been proposed to be involved in the aetiology of PD by facilitating neuronal degeneration and influence progression of the disease [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Handgrip Strength and Anthropometry in Parkinson’s Disease at Diagnosis

Håglin

Törnkvist

Edström

et al. 2022

Parkinson's Disease

View full text Add to dashboard Cite

Objectives. To investigate how age, malnutrition, and the level of plasma cortisol and phosphate in patients with Parkinson’s disease (PD) at time of diagnosis are associated with body composition and handgrip strength in males and females compared to controls. Materials & Methods. This cross-sectional study includes baseline data from a cohort of newly diagnosed patients with Parkinson’s disease (N = 75; M/F = 41/34) in the New Parkinsonism in Umeå study (NYPUM). Body Impedance (BIS), handgrip strength (HGS) assessments, and evaluation of risk for malnutrition (Mini Nutritional Assessment (MNA) score) and cognitive performance (Mini-Mental State Examination (MMSE)) were performed at time of PD diagnosis. Results. Low fat-free mass index (FFMI), MNA score, and a high Unified Parkinson’s Disease Rating Scale (UPDRS-total and UPDRS-III) were associated with high daytime levels of P-cortisol in total PD population but not in controls. Partial correlations reveal that high fat mass percent (FM (%)) and low FFMI were associated with older age in males with PD but not females with PD. Risk of malnutrition was associated with P-cortisol in males but not in females with PD (r = −0.511, P = 0.001 , and n = 41 and r = −0.055, P = 0.759 , and n = 34, respectively). Multiple linear regressions show that an interaction between P-cortisol and P-phosphate, older age, and high UPDRS-III score were associated with HGS in total patient population and males but not females. Conclusions. Age- and disease-associated risk factors that decrease muscle mass and HGS and increase FM (%) in patients with PD differ between males and females by an association with levels of cortisol and phosphate.

show abstract

“…For instance, loneliness is linked with greater cortisol awakening response in middle-aged adults ( Steptoe et al, 2013 ), and previous day loneliness results in heightened cortisol awakening response in older adults ( Adam, Hawkley, Kudielka, & Cacioppo, 2006 ). In PwP, cortisol-related pathological responses to stress has been shown to negatively affects both motor and non-motor symptoms of PD potentially even noticeable in the prodromal stage ( van Wamelen, Wan, Chaudhuri, & Jenner, 2020 ).…”

Section: Physiology Of Lonelinessmentioning

confidence: 99%