Stress and Deformation of Optimally Shaped Silicon Microneedles for Transdermal Drug Delivery

Abidin, Hafzaliza Erny Zainal; Ooi, Poh Choon; Tiong, Teck Yaw; Marsi, Noraini; Ismardi, Abrar; Noor, Mimiwaty Mohd; Fathi, Nik Amni Fathi Nik Zaini; Aziz, Norazreen Abd; Sahari, Siti Kudnie; Sugandi, Gandi; Yunas, Jumril; Dee, Chang Fu; Majlis, Burhanuddin Yeop; Hamzah, Azrul Azlan

doi:10.1016/j.xphs.2020.04.019

Cited by 15 publications

(3 citation statements)

References 17 publications

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“…Silicon MNs have significant strength mechanically, and this allows silicon MNs to sufficiently insert into skin [ 151 , 152 ]. Deformation and stress testing of silicon MNs of concave conic shape were undertaken to predict the incidence of MN deformation [ 153 ]. A skin penetration study was conducted on rat skin, where it was found that with increasing load (50–800 g), surface buckling deformation did not occur, indicating a good mechanical strength of the needles.…”

Section: Parameters Affecting Mn Insertionmentioning

confidence: 99%

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety of active compounds into the skin. To serve as a substitute for common hypodermic needles, MNs must pierce the human stratum corneum (~ 10 to 20 µm), without rupturing or bending during penetration. This ensures that the cargo is released at the predetermined place and time. Therefore, the ability of MN patches to sufficiently pierce the skin is a crucial requirement. In the current review, the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared. This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice. Factors that affect insertion (e.g., geometry, material composition and cross-linking of MNs), along with recent advancements in developed strategies (e.g., insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography) to improve the skin penetration are highlighted to provide a backdrop for future research.

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Section: Parameters Affecting Mn Insertionmentioning

confidence: 99%

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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“…In contrast, when 40 needles are manufactured, the tip truncation length is between 30 and 40 μm and corresponds to an insertion force between 7 and 11 mN. Abidin et al reported microneedle deformation in skin puncture with hollow conic shape microneedles; their stress results indicated that the maximum stress at the tip of the microneedle is 628 MPa and a resistive force of around 0.03 mN is required to pierce the human skin [34]. In our experiments, the maximum stresses at the tip were found with the lowest value of truncated tip length (Tt = 10 μm), resulting in 192 MPa.…”

Section: Discussionmentioning

confidence: 99%

“…Simplified versions of a microneedle and skin tissue were used to represent the insertion process during a puncturing process. The structural mechanic module and the solid mechanic physics were employed with linear-elastic modeling to perform stationary and linear buckling analyses [34,35]. Table 4 shows the physical property details of AISI 316 LVM from the literature [36][37][38] for the FEM simulation.…”

Section: In Silico Assesmentmentioning

confidence: 99%

Assessment of geometrical dimensions and puncture feasibility of microneedles manufactured by micromilling

Tamez-Tamez

Vázquez

Rodrı́guez

et al. 2023

Int J Adv Manuf Technol

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Microneedles are an emerging technology designed to deliver drugs into human tissue. In this work, we assess the microneedle’s manufacturability by employing micromilling with a minimum quantity lubrication (MQL) system. A set of AISI 316L square pyramidal microneedles was fabricated and characterized using dimensional and surface metrology. Needle height (Hn), base length (Lb), tip radius (Rt), and the tip’s angle (θ) were studied. Additionally, surface roughness was quantified to correlate surface topography damage with tool wear (Dr). Experimental data shows tip truncation after manufacturing 30 needles (i.e., a tip radius between ~32 μm and 49 μm for manufacturing 10 and 30 needles, respectively). Additionally, to evaluate the effect of the tip’s morphology on the proficiency of the microneedles for a puncture, a numerical analysis to study the impact of tip truncation length (Tt) on puncture with an in silico assessment using COMSOL Multiphysics was performed. Data and insights from this work suggest that micromilling microneedle arrays is viable, considering the number of needles machined according to the cutting parameters selected to ensure functionality.

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Mechanical Investigation of Solid MNs Penetration into Skin Using Finite Element Analysis

Liu,

Sun,

Zhang

et al. 2023

Adv Eng Mater

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In the past two decades, microneedles (MNs) patches as a promising platform have been extensively investigated for transdermal delivery of drug drugs, cells, and active substances and extraction of bio‐fluids. To realize painless, efficacious, and safe transdermal delivery, these MNs must penetrate the skin to the appropriate depth without breaking or bending. Therefore, effective prediction of mechanical properties such as skin penetration of microneedles is crucial for the material and structural design of MNs. In this article, a numerical simulation of the insertion process of the microneedle into various types of skin modeling is reported using the finite element method. The effective stress failure criterion has been coupled with the element deletion technique to predict the complete insertion process. The numerical results show a good agreement with the reported experimental data for the deformation and failure of the skin and the insertion force.

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Stress and Deformation of Optimally Shaped Silicon Microneedles for Transdermal Drug Delivery

Cited by 15 publications

References 17 publications

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Assessment of geometrical dimensions and puncture feasibility of microneedles manufactured by micromilling

Mechanical Investigation of Solid MNs Penetration into Skin Using Finite Element Analysis

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