Stress and depression-associated shifts in gut microbiota: A pilot study of human pregnancy

Rajasekera, Therese A.; Galley, Jeffrey D.; Mackos, Amy R.; Chen, Helen J.; Mitchell, Justin G.; Kleinman, Joshua J.; Cappelucci, Paige; Mashburn-Warren, Lauren; Lauber, Christian L.; Bailey, Michael T.; Worly, Brett L.; Gur, Tamar L.

doi:10.1016/j.bbih.2024.100730

Cited by 3 publications

(1 citation statement)

References 92 publications

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“…Prior studies, often relying on 16S sequencing, have typically reported associations at the genus level and above, identifying Intestinibacter and Escherichia Shigella as potential protective factors against prenatal depression, whereas Tyzzerella and unclassified members of the Ruminococcaceae family may pose an increased risk [17]. Moreover, a decline in Erysipelatoclostridium abundance correlates with more severe depressive symptoms [18]. Pregnant women experiencing anxiety have been found to have greater relative abundances of Acetitomaculum, Acidaminococcus, Oxalobacter, Rothia, and Staphylococcus [19].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Association between Anxiety, Depression, and Gut Microbiota during Pregnancy: Findings from a Pregnancy Cohort Study in Shijiazhuang, Hebei Province, China

Chi,

Li,

Zhang

et al. 2024

Nutrients

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Negative emotions and gut microbiota during pregnancy both bear significant public health implications. However, the relationship between them has not been fully elucidated. This study, utilizing data from a pregnancy cohort, employed metagenomic sequencing to elucidate the relationship between anxiety, depression, and gut microbiota’s diversity, composition, species, and functional pathways. Data from 87 subjects, spanning 225 time points across early, mid, and late pregnancy, were analyzed. The results revealed that anxiety and depression significantly corresponded to lower alpha diversity (including the Shannon entropy and the Simpson index). Anxiety and depression scores, along with categorical distinctions of anxiety/non-anxiety and depression/non-depression, were found to account for 0.723%, 0.731%, 0.651%, and 0.810% of the variance in gut-microbiota composition (p = 0.001), respectively. Increased anxiety was significantly positively associated with the abundance of Oscillibacter sp. KLE 1745, Oscillibacter sp. PEA192, Oscillibacter sp. KLE 1728, Oscillospiraceae bacterium VE202 24, and Treponema socranskii. A similar association was significantly noted for Oscillibacter sp. KLE 1745 with elevated depression scores. While EC.3.5.3.1: arginase appeared to be higher in the anxious group than in the non-anxious group, vitamin B12-related enzymes appeared to be lower in the depression group than in the non-depression group. The changes were found to be not statistically significant after post-multiple comparison adjustment.

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Section: Introductionmentioning

confidence: 99%

Exploring the Association between Anxiety, Depression, and Gut Microbiota during Pregnancy: Findings from a Pregnancy Cohort Study in Shijiazhuang, Hebei Province, China

Chi,

Li,

Zhang

et al. 2024

Nutrients

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Diet and the gut microbiota-immune axis in the context of perinatal mental health: Protocol for a prospective cohort study

Wallace,

Audet

2024

Womens Health (Lond Engl)

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Background: Physiological and psychosocial changes experienced by women during the perinatal period may put them at risk for postpartum mental health disturbances. Accumulating evidence suggests that dietary patterns may influence mental health through the modulation of the gut microbiota and its effects on host immune activity. Thus, targeting the gut microbiota via dietary intake could serve as both a preventative and therapeutic strategy in improving perinatal mental health. Objectives: Here, we present a protocol for a prospective cohort study that primarily aims to determine if diet quality during pregnancy is protective against postpartum depression severity. Secondary objectives will examine if microbiota- and blood-based inflammatory markers may be associated with the relationship between prenatal diet quality and postpartum depression severity, as well as with associations between additional dietary and mental health outcomes. Methods and Analysis: Dietary patterns and mental health symptoms will be documented in 100 pregnant women at 4 time points during pregnancy and postpartum. Participants will also provide stool and blood samples at the same time points to determine microbiota composition and predicted function and inflammatory factors, respectively. Stool microbiota will be analyzed using 16S ribosomal RNA gene sequencing and bioinformatics tools (QIIME 2/PICRUSt2). Inflammatory factors will be determined using high-sensitivity antibody-based immunoassays. Statistical analyses will include linear mixed models and hierarchical linear mixed effect models. Ethics: The study was approved by the Research Ethics Boards of the Royal Ottawa Health Care Group (#2022002) and of the University of Ottawa (#H-06-22-8013). Informed consent will be obtained from all participants before their enrollment. Discussion: Findings from this study will help develop evidence-based dietary recommendations and potential interventions for women susceptible to or suffering from postpartum mental health issues that are accessible, noninvasive, and have potential to play a role in prevention and treatment.

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Impact of the gut microbiota-Th17 cell axis on inflammatory depression

Jia,

Wang,

Ren

et al. 2024

Front. Psychiatry

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Depression is a serious cognitive disorder that results in significant and pervasive deficits in social behavior. These deficits can be traced back to the intricate interplay between social, psychological, and biological factors. Inflammatory depression, a treatment-resistant or non-responsive subtype of depression, may be related to the interaction between the gut microbiota and interleukin-17-producing CD4+ T cells (Th17 cells). The heterogeneity, plasticity, and effector role of Th17 cells in depression may be influenced by microbiota factors. Commensals-elicited homeostatic Th17 cells preserve the morphological and functional integrity of the intestinal barrier. In addition to pathogen-elicited inflammatory Th17 cells, commensal-elicited homeostatic Th17 cells can become conditionally pathogenic and contribute to the development of inflammatory depression. This review delves into the possible involvement of Th17 cells in inflammatory depression and examines the interplay between gut microbiota and either homeostatic or inflammatory Th17 cells.

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Stress and depression-associated shifts in gut microbiota: A pilot study of human pregnancy

Cited by 3 publications

References 92 publications

Exploring the Association between Anxiety, Depression, and Gut Microbiota during Pregnancy: Findings from a Pregnancy Cohort Study in Shijiazhuang, Hebei Province, China

Exploring the Association between Anxiety, Depression, and Gut Microbiota during Pregnancy: Findings from a Pregnancy Cohort Study in Shijiazhuang, Hebei Province, China

Diet and the gut microbiota-immune axis in the context of perinatal mental health: Protocol for a prospective cohort study

Impact of the gut microbiota-Th17 cell axis on inflammatory depression

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