Stress and epilepsy: fact or fiction, and what can we do about it?

Galtrey, Clare; Mula, Marco; Cock, Hannah R.

doi:10.1136/practneurol-2015-001337

Cited by 34 publications

(31 citation statements)

References 45 publications

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“…The dysregulation of the hypothalamus‐pituitary‐adrenocortical axis (HPA‐A), which is a hallmark of chronic stress, is associated with epilepsy and facilitates the epileptic process . There exists bidirectional connection between chronic stress and inflammation, whereby stress activates inflammatory responses, and conversely inflammation induces HPA‐A dysregulation …”

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confidence: 99%

Facilitation of kindling epileptogenesis by chronic stress may be mediated by intestinal microbiome

et al. 2018

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SummaryThere has been growing interest in the role of intestinal microbiome in brain disorders. We examined whether dysbiosis can predispose to epilepsy. The study was performed in female and male Sprague‐Dawley rats. To induce dysbiosis, the rats were subjected to chronic restraint stress (two 2‐h long sessions per day, over 2 weeks). Cecal content from stressed and sham‐stressed donors was transplanted via oral gavage to recipients, in which commensal microbiota had been depleted by the antibiotics. The study included the following groups: (1) Sham stress, no microbiota transplant; (2) Stress, no microbiota transplant; (3) Sham‐stressed recipients transplanted with microbiota from sham‐stressed donors; (4) Stressed recipients transplanted with microbiota from sham‐stressed donors; (5) Sham‐stressed recipients transplanted with microbiota from stressed donors; and (6) Stressed recipients transplanted with microbiota from stressed donors. After microbiota transplant, all animals were subjected to kindling of the basolateral amygdala. Both chronic stress and microbiome transplanted from stressed to sham‐stressed subjects accelerated the progression and prolonged the duration of kindled seizures. Microbiome from sham‐stressed animals transplanted to chronically stressed rats, counteracted proepileptic effects of restraint stress. These findings directly implicate perturbations in the gut microbiome, particularly those associated with chronic stress, in the increased susceptibility to epilepsy.

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confidence: 99%

Facilitation of kindling epileptogenesis by chronic stress may be mediated by intestinal microbiome

et al. 2018

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“…The link between stress and epilepsy remained quite controversial for a long time. There is now a substantial body of pre-clinical evidence suggesting that chronic stress can worsen seizures in established epilepsy and, in selected cases, may even be a causal factor in epilepsy (13). The paper by Gelisse is definitely along these lines and further confirms the need for healthcare professionals working with people with epilepsy to pay more attention to stress in clinical practice.…”

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confidence: 89%

New trends and hot topics in epileptology: An analysis of top articles published in Epilepsy & Behavior in 2015

Mula

2016

Epilepsy & Behavior

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“…In a similar manner, under stressful situations, hyper-secretion of glucocorticoids and other stress hormones may contribute to reductions in seizure threshold and increased neuronal excitability in TLE. Enhanced excitability may provide a potential mechanism underlying the propensity for TLE patients to identify stress as a common seizure trigger [9]. In fact, in some patients, evoking an emotional stressful response (i.e.…”

Section: Implications Of Hpa Axis Dysfunction In Tlementioning

confidence: 99%

“…Unpredictable seizures make many normal activities, like driving a car or holding down certain jobs, impossible [2]. Stress is repeatedly reported as one of the most common seizure triggers in patients with an epilepsy diagnosis, including TLE [3–9]. Understanding the molecular mechanisms underlying this association may allow clinicians to predict seizure episodes and/or mitigate their disruptive effect.…”

Section: Introductionmentioning

confidence: 99%