Stress and its impairment of skin barrier function

Lyu, Fan; Wu, Tong; Bian, Yizhe; Zhu, Kesen; Xu, Jinhua; Li, Fēi

doi:10.1111/ijd.16598

Cited by 6 publications

(6 citation statements)

References 27 publications

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“…In a currently conducted prospective observational study, Lyu et al. were able to show that PS—in this special case induced by poor sleep and severe anxiety—can harm skin barrier homeostasis in university students, 28 which corroborates the findings of the presented experimental skin bioengineering study. Garg et al.…”

Section: Discussionsupporting

confidence: 79%

Correlation of non‐invasive psycho‐physiological and skin‐physiological measures

Schürer,

Symanzik,

Kukshausen

et al. 2024

Skin Research and Technology

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IntroductionPsychological stress alters epidermal barrier function. While intensive studies on the underlying mechanism have been performed in mice, human studies are limited. Non‐invasive skin‐physiology measures have not yet been directly linked to non‐invasive psycho‐physiological assessments.MethodsStandard measures of (I) transepidermal water loss prior to and after experimental barrier perturbation via tape stripping, (II) skin surface pH, (III) electrodermal activity, and (IV) heart rate function were taken over a 24 h time period. To document perceived stress, a standardized stress self‐assessment questionnaire, namely the Trierer Inventar zum chronischen Stress (TICS), was utilized.ResultsTwenty healthy, Caucasian (Fitzpatrick skin phototype I‐II), female volunteers (21–32 years, mean age 27, SD = 3.67 years) were included in this study (random sample). Significant correlations were shown for 24 h delta transepidermal water loss changes, that is, barrier repair kinetics (sympathetic activity) and heart rate variability (parasympathetic activity). Further correlations were noted for electrodermal activity and skin surface pH. Perceived stress, as documented by the TICS questionnaire, did not correlate with psycho‐ and skin physiological parameters, respectively.ConclusionThe presented approaches may provide a basis for non‐invasive objective research on the correlation between psychological stressors and epidermal barrier function.

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Section: Discussionsupporting

confidence: 79%

Correlation of non‐invasive psycho‐physiological and skin‐physiological measures

Schürer,

Symanzik,

Kukshausen

et al. 2024

Skin Research and Technology

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“…We do not discuss them at our conferences. However, we know that sleep is an important factor for us, and quality of life in dermatologic patients 3 is an important aspect to consider. Very little data and RCT (Randomized Controlled Trial)/meta‐analysis are available on this aspect.…”

Section: Introductionmentioning

confidence: 99%

Sleep disorders in dermatology – a comprehensive review

Mann

Gorai

Staubach‐Renz

et al. 2023

J Deutsche Derma Gesell

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Summary Sleep is a normal physiological process that accounts for approximately one third of a person's life. Disruption of the normal sleep cycle, which maintains physiological homeostasis, can lead to pathology. It is not known whether sleep disturbance causes skin disease or skin disease causes sleep impairment, but a bidirectional influence is suspected. We have compiled the data from published articles on “sleep disorders in dermatology” in PubMed Central from July 2010 to July 2022 (with the option “full text available”) and provide an overview of sleep disorders associated with dermatological conditions and certain drugs used in dermatology as well as sleep disturbances for which some drugs used can cause itch or dermatological issues. Atopic dermatitis, eczema and psoriasis have been shown to be exacerbated by sleep problems and vice versa. Sleep deprivation, night‐time pruritus and disrupted sleep cycles are often used to assess treatment response and quality of life in these conditions. Some medications used primarily for dermatological conditions have also been associated with alterations in the sleep‐wake cycle. Addressing patients sleep disorders should be an integral part of the management of dermatological conditions. More studies are needed to further investigate the influence of sleep and skin disorders.

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“…Chronic stress leads to increased cortisol levels, which can alter the lipid content of the skin. Cortisol can decrease the synthesis of ceramides, cholesterol, and fatty acids, essential components of the skin's lipid barrier [41]. A decrease in these lipids weakens the barrier, making the skin more susceptible to irritants and microbial invasion, both of which can contribute to acne [42].…”

Section: Impaired Skin Barrier Functionmentioning

confidence: 99%

Exploring Stress-Induced Mechanisms in Acne Pathogenesis

Siddiqui,

Rais,

Tahir

2024

Preprint

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Background: Acne vulgaris affects millions worldwide, with psychological stress emerging as a significant contributor to its development. Stress influences acne via hormonal fluctuations, inflammation, immune modulation, altered skin barrier function, and lifestyle changes. Understanding these mechanisms is crucial for developing effective management strategies. This study aims to elucidate the role of stress in acne pathogenesis to inform more targeted interventions.Methods: A comprehensive search encompassing databases such as PubMed, MEDLINE, Google Scholar, open access / subscription-based journals, was conducted to retrieve relevant articles for the investigation of key mechanisms through which stress impacts acne development and exacerbation. Articles were searched without any date restrictions. Utilizing the criteria delineated in the methodology section, studies were systematically reviewed to elucidate the relationship between psychological stress and acne development and exacerbation. This study adheres to relevant PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).Results: Our investigation revealed multiple key mechanisms through which stress impacts acne development and exacerbation. Hormonal fluctuations, including increases in cortisol and androgens, stimulate sebaceous gland activity, leading to excess sebum production. Inflammation, triggered by stress-induced cytokine release, exacerbates acne lesions. Stress also impairs skin barrier function, alters immune responses, and influences lifestyle factors such as diet, sleep, and skincare habits, all of which contribute to acne severity. Additionally, neuropeptides, oxidative stress, insulin resistance, altered skin pH, vascular changes, and changes in the skin microbiome play significant roles in stress-induced acne pathogenesis. These findings highlight the varied nature of stress-acne interactions and underscore the importance of addressing both physiological and psychological factors in acne management strategies.Conclusion: Our investigation reveals stress's varied impact on acne through hormonal fluctuations, inflammation, barrier function impairment, immune modulation, behavioral factors, psychological distress, neuropeptides, oxidative stress, insulin resistance, altered skin pH, vascular changes, lifestyle habits, and skin microbiome alterations. Addressing these mechanisms underscores the need for holistic acne management strategies integrating stress reduction techniques with conventional treatments. Understanding stress-acne interplay emphasizes the importance of comprehensive approaches to improve acne outcomes, recognizing the bidirectional relationship between physiological and psychological factors in acne pathogenesis and exacerbation.

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Stress and its impairment of skin barrier function

Cited by 6 publications

References 27 publications

Correlation of non‐invasive psycho‐physiological and skin‐physiological measures

Correlation of non‐invasive psycho‐physiological and skin‐physiological measures

Sleep disorders in dermatology – a comprehensive review

Exploring Stress-Induced Mechanisms in Acne Pathogenesis

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