Stress and Loss of Ovarian Function

Kinkead, Richard; Gagnon, Marianne; Joseph, Vincent; Sériès, Frédéric; Marques, Danuzia A.

doi:10.1016/j.ccm.2021.04.002

Cited by 4 publications

(2 citation statements)

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“…The clinical manifestations and prevalence of SDB are sex specific (Kinkead et al, 2021). The occurrence of SDB is ∼2.5 times higher in men than in premenopausal women (Heinzer et al, 2015;Peppard et al, 2013), but pregnancy increases the occurrence of SDB from 10%…”

Section: Introductionmentioning

confidence: 99%

“…The clinical manifestations and prevalence of SDB are sex specific (Kinkead et al., 2021 ). The occurrence of SDB is ∼2.5 times higher in men than in premenopausal women (Heinzer et al., 2015 ; Peppard et al., 2013 ), but pregnancy increases the occurrence of SDB from 10% to 27% between the first and third trimester, thus reaching a level similar to men (Dominguez et al., 2018 ; Pien et al., 2014 ; Young et al., 1993 ).…”

Section: Introductionmentioning

confidence: 99%

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Gestational intermittent hypoxia increases FosB‐immunoreactive perikaryas in the paraventricular nucleus of the hypothalamus of adult male (but not female) rats

Ambrozio‐Marques,

Gagnon,

Radcliff

et al. 2023

Experimental Physiology

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Sleep‐disordered breathing is a respiratory disorder commonly experienced by pregnant women. The recurrent hypoxaemic events associated with sleep‐disordered breathing have deleterious consequences for the mother and fetus. Adult male (but not female) rats born to dams subjected to gestational intermittent hypoxia (GIH) have a higher resting blood pressure than control animals and show behavioural/neurodevelopmental disorders. The origin of this persistent, sex‐specific effect of GIH in offspring is unknown, but disruption of the neuroendocrine stress pathways is a key mechanism by which gestational stress increases disease risk in progeny. Using FosB immunolabelling as a chronic marker of neuronal activation, we determined whether GIH augments basal expression of FosB in the perikaryas of cells in the paraventricular nucleus of the hypothalamus (PVN), a key structure in the regulation of the stress response and blood pressure. From gestational day 10, female rats were subjected to GIH for 8 h/day (light phase) until the day before delivery (gestational day 21); GIH consisted of 2 min hypoxic bouts (10.5% O2) alternating with normoxia. Control rats were exposed to intermittent normoxia over the same period (GNX). At adulthood (10–15 weeks), the brains of male and female rats were harvested for FosB immunohistochemistry. In males, GIH augmented PVN FosB labelling density by 30%. Conversely, PVN FosB density in GIH females was 28% lower than that of GNX females. We conclude that GIH has persistent and sex‐specific impacts on the development of stress pathways, thereby offering a plausible mechanism by which GIH can disturb neural development and blood pressure homeostasis in adulthood.New FindingsWhat is the central question of this study?In pregnant women, sleep apnoea increases the risk of disease for the offspring at various life stages. Given that gestational stress disrupts the programming of the stress pathways, we determined whether exposing female rats to gestational intermittent hypoxia (GIH) activates hypothalamic neurons regulating the stress response in adult rats.What is the main finding and its importance?Using FosB immunolabelling as a marker of marker of neuronal activation, we showed that GIH augmented basal activation of the paraventricular nucleus of the hypothalamus in males, but not females. Disruption of the stress pathways is a new hypothesis to explain the persistent and sex‐specific impacts of GIH on offspring health.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gestational intermittent hypoxia increases FosB‐immunoreactive perikaryas in the paraventricular nucleus of the hypothalamus of adult male (but not female) rats

Ambrozio‐Marques,

Gagnon,

Radcliff

et al. 2023

Experimental Physiology

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Association of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatment

Cai,

Wang,

Zhao

et al. 2024

Sci Rep

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Cerebral Erythropoietin Prevents Sex-Dependent Disruption of Respiratory Control Induced by Early Life Stress

et al. 2021

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Injuries that occur early in life are often at the root of adult illness. Neonatal maternal separation (NMS) is a form of early life stress that has persistent and sex-specific effects on the development of neural networks, including those that regulate breathing. The release of stress hormones during a critical period of development contributes to the deleterious consequences of NMS, but the role of increased corticosterone (CORT) in NMS-induced respiratory disturbance is unknown. Because erythropoietin (EPO) is a potent neuroprotectant that prevents conditions associated with hyperactivation of the stress neuroaxis in a sex-specific manner, we hypothesized that EPO reduces the sex-specific alteration of respiratory regulation induced by NMS in adult mice. Animals were either raised under standard conditions (controls) or exposed to NMS 3 h/day from postnatal days 3–12. We tested the efficacy of EPO in preventing the effects of NMS by comparing wild-type mice with transgenic mice that overexpress EPO only in the brain (Tg21). In 7-days-old pups, NMS augmented CORT levels ~2.5-fold by comparison with controls but only in males; this response was reduced in Tg21 mice. Respiratory function was assessed using whole-body plethysmography. Apneas were detected during sleep; the responsiveness to stimuli was measured by exposing mice to hypoxia (10% O2; 15 min) and hypercapnia (5% CO2; 10 min). In wild-type, NMS increased the number of apneas and the hypercapnic ventilatory response (HcVR) only in males; with no effect on Tg21. In wild-type males, the incidence of apneas was positively correlated with HcVR and inversely related to the tachypneic response to hypoxia. We conclude that neural EPO reduces early life stress-induced respiratory disturbances observed in males.

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Stress and Loss of Ovarian Function

Cited by 4 publications

References 170 publications

Gestational intermittent hypoxia increases FosB‐immunoreactive perikaryas in the paraventricular nucleus of the hypothalamus of adult male (but not female) rats

Gestational intermittent hypoxia increases FosB‐immunoreactive perikaryas in the paraventricular nucleus of the hypothalamus of adult male (but not female) rats

Association of sleep disturbances with diminished ovarian reserve in women undergoing infertility treatment

Cerebral Erythropoietin Prevents Sex-Dependent Disruption of Respiratory Control Induced by Early Life Stress

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