Stress and Mindfulness in Parkinson's Disease: Clinical Effects and Potential Underlying Mechanisms

Heide, Anouk van der; Meinders, Marjan J.; Speckens, Anne E. M.; Peerbolte, Tessa F.; Bloem, Bastiaan R.; Helmich, Rick C.

doi:10.1002/mds.28345

Cited by 44 publications

(25 citation statements)

References 47 publications

(84 reference statements)

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“…Stress and mindfulness studies are beginning to demonstrate that being mindful can substantially benefit PwP [108,109]. Exercise studies have also been performed to address non-motor symptoms in PD [10][11][12]35,50].…”

Section: Restorative Options For Treating Pdmentioning

confidence: 99%

Treatment Options for Motor and Non-Motor Symptoms of Parkinson’s Disease

Church

2021

Biomolecules

131

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Parkinson’s disease (PD) usually presents in older adults and typically has both motor and non-motor dysfunctions. PD is a progressive neurodegenerative disorder resulting from dopaminergic neuronal cell loss in the mid-brain substantia nigra pars compacta region. Outlined here is an integrative medicine and health strategy that highlights five treatment options for people with Parkinson’s (PwP): rehabilitate, therapy, restorative, maintenance, and surgery. Rehabilitating begins following the diagnosis and throughout any additional treatment processes, especially vis-à-vis consulting with physical, occupational, and/or speech pathology therapist(s). Therapy uses daily administration of either the dopamine precursor levodopa (with carbidopa) or a dopamine agonist, compounds that preserve residual dopamine, and other specific motor/non-motor-related compounds. Restorative uses strenuous aerobic exercise programs that can be neuroprotective. Maintenance uses complementary and alternative medicine substances that potentially support and protect the brain microenvironment. Finally, surgery, including deep brain stimulation, is pursued when PwP fail to respond positively to other treatment options. There is currently no cure for PD. In conclusion, the best strategy for treating PD is to hope to slow disorder progression and strive to achieve stability with neuroprotection. The ultimate goal of any management program is to improve the quality-of-life for a person with Parkinson’s disease.

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Section: Restorative Options For Treating Pdmentioning

confidence: 99%

Treatment Options for Motor and Non-Motor Symptoms of Parkinson’s Disease

Church

2021

Biomolecules

131

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“…73 Other classical examples of mismatch between clinician's impression and patients' complaints are tremors, irrespective of cause. 105,129,130 The amplitude of tremor increases during emotional tension, and the situation captured in the clinic may overestimate or Bradykinesia Visual and auditory input External verbal or visual cues draw attention toward the movements and thus encourage patients to perform them less automatically. They may improve performance and mask bradykinesia or hypokinesia.…”

Section: Mismatch Between Patients' Complaints and Clinical Findingsmentioning

confidence: 99%

“…Other classical examples of mismatch between clinician's impression and patients' complaints are tremors, irrespective of cause 105,129,130 . The amplitude of tremor increases during emotional tension, and the situation captured in the clinic may overestimate or underestimate the severity of tremor compared to its everyday impact.…”

Section: Clinical Relevance Of Movement Disorders Variabilitymentioning

confidence: 99%

Variability of Movement Disorders: The Influence of Sensation, Action, Cognition, and Emotions

et al. 2020

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A BS TRACT: Patients with movement disorders experience fluctuations unrelated to disease progression or treatment. Extrinsic factors that contribute to the variable expression of movement disorders are environment related. They influence the expression of movement disorders through sensory-motor interactions and include somatosensory, visual, and auditory stimuli. Examples of somatosensory effects are stimulus sensitivity of myoclonus on touch and sensory amelioration in dystonia but also some less-appreciated effects on parkinsonian tremor and gait. Changes in visual input may affect practically all types of movement disorders, either by loss of its compensatory role or by disease-related alterations in the pathways subserving visuomotor integration. The interaction between auditory input and motor function is reflected in simple protective reflexes and in complex behaviors such as singing or dancing. Various expressions range from the effect of music on parkinsonian bradykinesia to tics. Changes in body position affect muscle tone and may result in marked fluctuations of rigidity or may affect dystonic manifestations. Factors intrinsic to the patient are related to their voluntary activity and cognitive, motivational, and emotional states. Depending on the situation or disease, they may improve or worsen movement disorders. We discuss various factors that can influence the phenotypic variability of movement disorders, highlighting the potential mechanisms underlying these manifestations. We also describe how motor fluctuations can be provoked during the clinical assessment to help reach the diagnosis and appreciated to understand complaints that seem discrepant with objective findings. We summarize advice and interventions based on the variability of movement disorders that may improve patients' functioning in everyday life.

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“…Furthermore, stress worsened tremors, FoG, and dyskinesia. Thus, the authors suggested further investigation using wearable sensors [21].…”

Section: Introductionmentioning

confidence: 99%

Predicting Wearing-Off of Parkinson’s Disease Patients Using a Wrist-Worn Fitness Tracker and a Smartphone: A Case Study

et al. 2021

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Parkinson’s disease (PD) patients experience varying symptoms related to their illness. Therefore, each patient needs a tailored treatment program from their doctors. One approach is the use of anti-PD medicines. However, a “wearing-off” phenomenon occurs when these medicines lose their effect. As a result, patients start to experience the symptoms again until their next medicine intake. In the long term, the duration of “wearing-off” begins to shorten. Thus, patients and doctors have to work together to manage PD symptoms effectively. This study aims to develop a prediction model that can determine the “wearing-off” of anti-PD medicine. We used fitness tracker data and self-reported symptoms from a smartphone application in a real-world environment. Two participants wore the fitness tracker for a month while reporting any symptoms using the Wearing-Off Questionnaire (WoQ-9) on a smartphone application. Then, we processed and combined the datasets for each participant’s models. Our analysis produced prediction models for each participant. The average balanced accuracy with the best hyperparameters was at 70.0–71.7% for participant 1 and 76.1–76.9% for participant 2, suggesting that our approach would be helpful to manage the “wearing-off” of anti-PD medicine, motor fluctuations of PD patients, and customized treatment for PD patients.

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Stress and Mindfulness in Parkinson's Disease: Clinical Effects and Potential Underlying Mechanisms

Cited by 44 publications

References 47 publications

Treatment Options for Motor and Non-Motor Symptoms of Parkinson’s Disease

Treatment Options for Motor and Non-Motor Symptoms of Parkinson’s Disease

Variability of Movement Disorders: The Influence of Sensation, Action, Cognition, and Emotions

Predicting Wearing-Off of Parkinson’s Disease Patients Using a Wrist-Worn Fitness Tracker and a Smartphone: A Case Study

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