“…Development (amount and location) of stress/strain in a structure significantly depends upon its geometrical features and the loading conditions. In TO, one can find approaches that impose stress constraints (Duysinx and Bendsøe, 1998;Luo et al, 2013;da Silva et al, 2019), and also, on stress isolation at predefined regions within the design domain (Li and Wang, 2014;Luo et al, 2017;Picelli et al, 2018). Our aim here is not to isolate strain (Picelli et al, 2018) in the design domain but rather to achieve a target strain level in the biological tissue substrates using optimized compliant mechanisms.…”