Stress as a Common Risk Factor for Obesity and Addiction

Sinha, Rajita; Jastreboff, Ania M.

doi:10.1016/j.biopsych.2013.01.032

Cited by 470 publications

(401 citation statements)

References 103 publications

(182 reference statements)

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“…The neurobiology of stress is associated with hunger and energy. Those mechanisms should be the focus of further research [42]. Help should be provided to obese individuals who suffer from stress [43].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Stress and Severe Obesity: A Case-Control Study

Koski

Naukkarinen

2017

Biomed Hub

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Background: Several etiological factors for obesity have been identified, whereas other factors related to obesity, such as stress, remain poorly understood. This study used psychiatric methods to examine the relationship between stress and obesity. Methods: Matched study and control groups were established, and the female and male control subjects were selected separately by random sampling. The control subjects were matched with the case subjects with respect to place of residence, sex, age, date that a pension was granted, and occupation. Psychiatric and psychological methods were assessed using a questionnaire and statistical analyses. Results: Psychiatric interviews indicated that stress was more prevalent in the study group than in the control group. Separation from parents was nearly significantly more frequently in the study group than in the control group. The questionnaire on coping mechanisms revealed that case subjects tended to resolve their problems in an active manner. Conclusions: The aim of this case-control study was to examine the relationship between stress and obesity in individuals receiving a disability pension. We identified stress factors that affect the development of obesity. We believe our study is both necessary and important, as these findings provide valuable insight into the relationship between severe obesity and stress.

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Section: Discussionmentioning

confidence: 99%

The Relationship between Stress and Severe Obesity: A Case-Control Study

Koski

Naukkarinen

2017

Biomed Hub

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“…Conversely, and supporting the bidirectional relationship between obesity and depression, the rates of obesity are particularly high in depressed patients, and depression was found to represent a strong predictor of weight gain and obesity, probably owing to effects of antidepressant medications and changes in eating behaviors and lifestyle (Lasserre et al, 2014;Lee et al, 2016;Simon et al, 2008). Moreover, psychosocial stress, a notorious risk factor for depression, is also known to contribute to weight gain and metabolic alterations and to participate in the development of obesity (Chuang et al, 2010;Kendler et al, 1999;Sinha and Jastreboff, 2013).…”

Section: Fat and Depression: A Vicious Circlementioning

confidence: 95%

Role of Adiposity-Driven Inflammation in Depressive Morbidity

Capuron

Lasselin

Castanon

2016

Neuropsychopharmacol

141

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Depression and metabolic disorders, including overweight and obesity, appear tightly interrelated. The prevalence of these conditions is concurrently growing worldwide, and both depression and overweight/obesity represent substantial risk factors for multiple medical complications. Moreover, there is now multiple evidence for a bidirectional relationship between depression and increased adiposity, with overweight/obesity being associated with an increased prevalence of depression, and in turn, depression augmenting the risk of weight gain and obesity. Although the reasons for this intricate link between depression and increased adiposity remain unclear, converging clinical and preclinical evidence points to a critical role for inflammatory processes and related alterations of brain functions. In support of this notion, increased adiposity leads to a chronic low-grade activation of inflammatory processes, which have been shown elsewhere to have a potent role in the pathophysiology of depression. It is therefore highly possible that adiposity-driven inflammation contributes to the development of depressive disorders and their growing prevalence worldwide. This review will present recent evidence in support of this hypothesis and will discuss the underlying mechanisms and potential therapeutic targets. Altogether, findings presented here should help to better understand the mechanisms linking adiposity to depression and facilitate the identification of new preventive and/or therapeutic strategies.

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“…in type 1 and type 2 diabetes [19]. It influences brain function [20], memory [20], appetite [21] [22] and the cognitive response i.e. the ability of the brain to function and is associated with the regulatory and/or causal mechanism rather than the visceral or symptomatic consequences.…”

Section: Discussion Of the Different Factors Which Influence The Onsementioning

confidence: 99%

A Neurological Perspective upon Diabetes and Obesity, What They Are, and How They Can Be Measured

Ewing¹

2018

CRCM

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New technologies bring new insights. The existence of the first mathematical model of how the brain regulates the autonomic nervous system and physiological systems, and knowledge of how this can be applied to screen or treat the diabetic, enables the author to take a comprehensive view of the etiology of diabetes and obesity. This paper illustrates the dynamic relationship between the brain, physiological systems and visceral organs. It highlights that 1) blood glucose is a neurally regulated physiological system, and/or network of organs, which function coherently in order to maintain blood glucose within normal physiological limits; and 2) that dysregulation of this physiological system (regulation of blood glucose levels), by genetic or phenotypic pathologies in the organs in this system, influences the prevailing levels of insulin, directly influences brain function and hence the coherent function of this and other physiological systems and organs e.g. blood pressure, sleep, pH, digestion, sexual function, etc. In addition 3) the observation that proteins may be coiled and reactive, or uncoiled and resist reacting with their reactive substrates, leads to a greater level of understanding of the mechanisms responsible for type 2 diabetes and obesity and how such conditions could be screened and treated.

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Stress as a Common Risk Factor for Obesity and Addiction

Cited by 470 publications

References 103 publications

The Relationship between Stress and Severe Obesity: A Case-Control Study

The Relationship between Stress and Severe Obesity: A Case-Control Study

Role of Adiposity-Driven Inflammation in Depressive Morbidity

A Neurological Perspective upon Diabetes and Obesity, What They Are, and How They Can Be Measured

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