A resin transfer molding technique was used to fabricate thick-walled composite connecting rods, and then the mechanical performance of the connecting rod was studied experimentally, at the same time the stress and failure index distributions were simulated numerically. The experimental results show that under a tensile load, the connecting rod first cracks near the vertex of the triangle areas at the two ends, and then the damage propagates along the interface between the main bearing beam and the triangle area as well as along the round angle of the triangle area. Whereas under a compressive load, the delamination primarily occurs at the corner of the U-shaped flange, and the final destruction is caused by the fracture of fibers in the main bearing beam. The simulated results reveal that the tensile failure is originated from the delamination at the round angle transition areas of the T-joints, and the failure strength is determined by the interlaminar strength. Whereas the compressive failure is caused by the fracture of fibers in the main bearing beam, and the failure strength of the structure is determined by the longitudinal compressive strength of the composite material. The simulated results are basically consistent with the experimental results. Hence the mechanical performance and failure mechanism of the complicated composite structure are revealed in great detail through the coupling of the two kinds of research methods, which is helpful for the optimal design of composite structures.