The purpose of this paper is to investigate the stress concentration factor(SCF) for an internallypressurized cylinder with hole and based on detailed three-dimensional elastic FE analysis, a newcomprehensive set of formulas for SCFs are proposed. These stress concentration factors are presentedand discussed as a function of the ratio of cylinder diameter to the thickness of cylinder and hole diameter.The first ratio “D/100t” is equal to 1, 1.25, 1.5, 1.75, 2, 2.5, 2.75, 3, 3.25 and 3.5 and the second ratio“D/10d”, cylinder internal diameter to the hole diameter, varies from 0.6, 0.9, 1.2, 1.5, 1.8, 2, 2.3, 2.7,3.1and 3.5. Results are also presented for SCF of longitudinal, circumferential and Von Mises stresses.