Stress, Corticoliberin (CRF), and Glucocorticoids in the Regulation of ACTH Release

Stark, E.; Makara, Gábor B.

doi:10.1007/978-1-4615-9248-8_9

Cited by 2 publications

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“…It has been also demonstrated that ACTH and cortico sterone secretion cannot be stimulated in deafferented rats subjected to several stressors [7,14,16]. The results were in terpreted to suggest that stressful stimuli were ineffective in these animals because of the irreversible interruption of Received: July 14, 1982 Accepted after revision: November 15, 1982 CRF-transporting pathways originating outside of the MBH [16,22]. However, we could not exclude the possibili ty that the responsiveness of the pituitary towards CRF is decreased by these surgical interventions, and is, at least partly, the cause of the diminished stress response.…”

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confidence: 91%

Responsiveness of Adenohypophysial Corticotrophs to Hypothalamic (SME) Extract Remains Unchanged in Rats with Hypothalamic Lesions Inhibiting CRF Release

Stark¹,

Kárteszi²,

Makara³

1983

Neuroendocrinology

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The corticotrophin-releasing activity of stalk-median eminence (SME) extract was studied using incubated quarters of anterior pituitary glands obtained from rats with long-term anterolateral deafferentation or complete surgical lesion of the medial basal hypothalamus, as well as with the lesion of the paraventricular nuclei. These hypothalamic interventions are known to cause a complete or partial but significant deficiency in hypothalamic corticotrophin-releasing factor (CRF) release, however, such lesions failed to alter the sensitivity of the ACTH response from incubated pituitary segments towards the SME extract. These results suggest that the specific responsiveness of adenohypophysial corticotrophs is maintained when hypothalamic CRF supply is decreased for a long period of time.

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confidence: 91%