The fruit fly optimization algorithm-general regression neural network (FOA-GRNN) coupled model and the Finite Element Method-Smoothed Particle Hydrodynamics (FEM-SPH) numerical calculation method are comprehensively used. The control problem of blasting vibration in the process of mining hidden resources under complex environmental conditions has been studied. Taking a lead-zinc mine as the engineering background, the development of hidden resources in the collapse area due to unreasonable mining was studied. Based on the establishment of the first mining stope and its mining method in this area, biosimulation and generalized neural networks were introduced to solve this problem, the coupling of blasting parameters was analyzed, and the 3D nonlinear dynamic coupling model was constructed for numerical simulation. The results show that the blasting parameters of deep-hole mining were optimized, including the values of six output quantities: hole distance, row spacing, side hole distance, explosive unit consumption, minimum resistance line, and interval ratio (the Root Mean Squared Error value is only 0.051). The error between the network optimization parameters and the empirically obtained values was controlled to within 0.05; five possible edge-hole charge structures were designed (the interval ratio is 0.696), and the vibration velocity peak and pressure peak variations with time after detonation are reflected by the simulation results. The dynamic evolution law of the rock mass velocity vector and the damage of the rock damage was revealed. According to the analysis in this paper, the smallest and optimal edge-hole charge structure of the surrounding rock was obtained.