Stress down south: meeting report of the fifth International Workshop on the Molecular Biology of Stress Responses

Multhoff, Gabriele; Maio, Antonio De

doi:10.1379/csc-203.1

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Hsp Formation In Skin Cells1

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2015

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“…Besides, not only rising body temperature but also heavy metals (As, Cd), ethanol, oxygen radicals, and peroxides are agents that can induce heat-shock responses [ 68 ]. Based on these data, Gabriele Multhoff proposed that the real inducer of Hsps is the presence of denatured proteins within the cell [ 69 ]. This hypothesis was supported by experiments in which heat-shock responses were also induced by microinjection of denatured protein into the cells [ 70 ].…”

Section: Hsp Formation In Skin Cellsmentioning

confidence: 99%

Role of TRP channels in the induction of heat shock proteins (Hsps) by heating skin

Hsu

Yoshioka

2015

BIOPHYSICS

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Transient receptor potential (TRP) channels in skin are crucial for achieving temperature sensitivity to maintain internal temperature balance and thermal homeostasis, as well as to protect skin cells from environmental stresses such as infrared (IR) or near-infrared (NIR) radiation via heat shock protein (Hsp) production. However, the mechanisms by which IR and NIR activate TRP channels and produce Hsps intracellularly have been independently reported. In this review, we discuss the relationship between TRP channel activation and Hsp production, and introduce the roles of several skin TRP channels in the regulation of HSP production by IR and NIR exposure.

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Section: Hsp Formation In Skin Cellsmentioning

confidence: 99%