Stress-driven collagen fiber remodeling in arterial walls

Hariton, I.; deBotton, Gal; Gasser, Thomas C.; Holzapfel, Gerhard

doi:10.1007/s10237-006-0049-7

Cited by 159 publications

(112 citation statements)

References 50 publications

Supporting

Mentioning

106

Contrasting

Order By: Relevance

“…It is not intended to explain the origin of remodeling with its highly complex interactive phenomena between extracellular matrix molecules and living cells at the micro-level, which are still not fully understood. In accordance to previous computational remodeling approaches (Taber and Humphrey 2001;Gleason and Humphrey 2004;Hariton et al 2007;Ricken et al 2007), the present algorithm is stimulated by the stress environment at the macro or tissue level. Traditionally, remodeling algorithms for biological tissues can be classified into stress driven (Taber and Humphrey 2001;Gleason and Humphrey 2004;Hariton et al 2007;Ricken et al 2007) or strain driven formulations (Driessen et al 2004;Kuhl et al 2005;Himpel et al 2008).…”

Section: Introductionmentioning

confidence: 64%

A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells

Grytz

Meschke

2009

Biomech Model Mechanobiol

View full text Add to dashboard Cite

Organized collagen fibrils form complex networks that introduce strong anisotropic and highly nonlinear attributes into the constitutive response of human eye tissues. Physiological adaptation of the collagen network and the mechanical condition within biological tissues are complex and mutually dependent phenomena. In this contribution, a computational model is presented to investigate the interaction between the collagen fibril architecture and mechanical loading conditions in the corneo-scleral shell. The biomechanical properties of eye tissues are derived from the single crimped fibril at the micro-scale via the collagen network of distributed fibrils at the meso-scale to the incompressible and anisotropic soft tissue at the macro-scale. Biomechanically induced remodeling of the collagen network is captured on the meso-scale by allowing for a continuous re-orientation of preferred fibril orientations and a continuous adaptation of the fibril dispersion. The presented approach is applied to a numerical human eye model considering the cornea and sclera. The predicted fibril morphology correlates well with experimental observations from X-ray scattering data.

show abstract

Section: Introductionmentioning

confidence: 64%

A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells

Grytz

Meschke

2009

Biomech Model Mechanobiol

View full text Add to dashboard Cite

show abstract

“…Indeed, if dF/dP ¼ 0 represents a normal configuration for the artery in vivo, this can be reached by the deposition of collagen fibers at a certain angle to the circumferential direction. Several scientific papers have reported that remodeling processes may act on the deposition of collagen fibers [27] and that axial stresses may affect these remodeling processes. This view is fully consistent with our model.…”

Section: Implications On the Orientation And Deposition Of Collagen Fmentioning

confidence: 99%

Biomechanics of Porcine Renal Arteries and Role of Axial Stretch

Avril¹,

Badel

Gabr

et al. 2013

Journal of Biomechanical Engineering

View full text Add to dashboard Cite

It is known that arteries experience significant axial stretches in vivo. Several authors have shown that the axial force needed to maintain an artery at its in vivo axial stretch does not change with transient cyclical pressurization over normal ranges. However, the axial force phenomenon of arteries has never been explained with microstructural considerations. In this paper we propose a simple biomechanical model to relate the specific axial force phenomenon of arteries to the predicted load-dependent average collagen fiber orientation. It is shown that (a) the model correctly predicts the authors' experimentally measured biaxial behavior of pig renal arteries and (b) the model predictions are in agreement with additional experimental results reported in the literature. Finally, we discuss the implications of the model for collagen fiber orientation and deposition in arteries.

show abstract

“…In this sense, much effort is directed towards representing remodelling in vascular tissue [40][41][42][43], with a particular focus on the pathological remodelling observed in aortic aneurysm tissue [44][45][46]. The mathematical modelling of the inflammation, proliferation and remodelling phases in ligament tissue has also been addressed [47,48].…”

Section: Introductionmentioning

confidence: 99%

A homeostatic-driven turnover remodelling constitutive model for healing in soft tissues

Comellas

Gasser

Bellomo

et al. 2016

J. R. Soc. Interface.

View full text Add to dashboard Cite

Remodelling of soft biological tissue is characterized by interacting biochemical and biomechanical events, which change the tissue's microstructure, and, consequently, its macroscopic mechanical properties. Remodelling is a well-defined stage of the healing process, and aims at recovering or repairing the injured extracellular matrix. Like other physiological processes, remodelling is thought to be driven by homeostasis, i.e. it tends to re-establish the properties of the uninjured tissue. However, homeostasis may never be reached, such that remodelling may also appear as a continuous pathological transformation of diseased tissues during aneurysm expansion, for example. A simple constitutive model for soft biological tissues that regards remodelling as homeostatic-driven turnover is developed. Specifically, the recoverable effective tissue damage, whose rate is the sum of a mechanical damage rate and a healing rate, serves as a scalar internal thermodynamic variable. In order to integrate the biochemical and biomechanical aspects of remodelling, the healing rate is, on the one hand, driven by mechanical stimuli, but, on the other hand, subjected to simple metabolic constraints. The proposed model is formulated in accordance with continuum damage mechanics within an open-system thermodynamics framework. The numerical implementation in an in-house finite-element code is described, particularized for Ogden hyperelasticity. Numerical examples illustrate the basic constitutive characteristics of the model and demonstrate its potential in representing aspects of remodelling of soft tissues. Simulation results are verified for their plausibility, but also validated against reported experimental data.

show abstract

Stress-driven collagen fiber remodeling in arterial walls

Cited by 159 publications

References 50 publications

A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells

A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells

Biomechanics of Porcine Renal Arteries and Role of Axial Stretch

A homeostatic-driven turnover remodelling constitutive model for healing in soft tissues

Contact Info

Product

Resources

About