Stress functional MRI: Detection of ischemic heart disease and myocardial viability

Sechtem, Udo; Baer, Frank M.; Voth, E.; Theissen, P.; Schneider, Christian A.

doi:10.1002/(sici)1522-2586(199911)10:5<667::aid-jmri9>3.0.co;2-8

Cited by 20 publications

(4 citation statements)

References 43 publications

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“…The threshold value was chosen as 5.5 mm. This value is the accepted cutoff value that is obtained after comparing the healthy volunteer's and patients with pathologic positron emission tomography and single-photon emission computed tomography findings (9). We found the end diastolic wall thickness of nine patients as 5.5 mm or less.…”

Section: Sensky Et Almentioning

confidence: 99%

Cardiac MRI in Ischemic Heart Disease with Severe Coronary Artery Stenosis

et al. 2006

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Section: Sensky Et Almentioning

confidence: 99%

Cardiac MRI in Ischemic Heart Disease with Severe Coronary Artery Stenosis

et al. 2006

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“…MRI also provides functional information at rest and in response to pharmacologic stress [73][74]. Thus, it has been used serially in assessing changes in global and regional function in chronic heart failure [79][80][81] and in determining myocardial viability [82][83][84]. Baer et al [85] found that viable myocardium is characterized on MRI as regions with preserved end-diastolic wall thickness of 5.5 mm or more and dobutamine-elicited systolic wall thickening of at least 1mm.…”

Section: Cardiac Functionmentioning

confidence: 99%

Usefulness of Magnetic Resonance Imaging in Cardiac and Enovascular Intervention

Saeed¹

2006

CMIR

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Assessment of ischemic heart disease is an important application of magnetic resonance imaging (MRI). This noninvasive diagnostic technique has the potential to evaluate different aspects of ischemic heart disease such as myocardial function, perfusion and the extent of acute and chronic infarctions. MRI is becoming an alternative technique for assessment of myocardial viability by predicting systolic recovery of stunned and hibernating myocardium after revascularization. MR contrast agents provide additional information on residual myocardial viability, myocardial perfusion, coronary angiography and microvascular integrity. Recent technologic improvements in scanners, sequences and post-processing of images showed the potentiality of MR-guided procedures. This review begins with a brief overview of magnetic resonance properties and MR contrast agents and proceeds to their applications in cardiac imaging and endovascular intervention. The next generation of MR contrast agents will likely focus on increase detection sensitivity so that minor tissue changes can be detected, prolonging intravascular retention (blood pool contrast agents), improving tissue targeting (tissue and molecule specific contrast agents and probes) and molecular imaging. MRI will play viable role in cardiovascular imaging and intervention in the near future and it may have the potential to complement other commonly used diagnostic modalities.

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“…Noncontrast-enhanced MRI has been employed to assess myocardial viability using regional left ventricular wall thickening, thickness. stress, and strain during rest and pharmacologic-stress (dobutamine) (75)(76)(77)(78)(79)(80)(81)(82)(83). Sodium MRI has also been used to monitor the accumulation of sodium in necrotic myocardium (83,84).…”

Section: Assessment Of Myocardial Injuries By Noncontrast-enhanced Mrimentioning

confidence: 99%

“…On functional MRI, a decreased wall thickening at rest and normal contraction after dobutamine characterized stunned myocardium. whereas infarcted myocardium is characterized by persistent dysfunction (76)(77)(78).…”

Section: Assessment Of Myocardial Injuries By Noncontrast-enhanced Mrimentioning

confidence: 99%

New Concepts in Characterization of Ischemically Injured Myocardium by MRI

Saeed

2001

Exp Biol Med (Maywood)

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New concepts regarding the assessment of ischemic myocardial injuries have been addressed in this Minireview using magnetic resonance imaging (MRI). MRI, with its different techniques, brings not only anatomic, but also physiologic, information on ischemic heart disease. It has the ability to measure identical parameters in preclinical and clinical studies. MRI techniques provide the ideal package for repeated and noninvasive assessment of myocardial anatomy, viability, perfusion, and function. MR contrast agents can be applied in a variety of ways to improve MRI sensitivity for detecting and assessing ischemically injured myocardium. With MR contrast agents protocol, it becomes possible to identify ischemic, acutely infarcted, and peri-infarcted myocardium in occlusive and reperfused infarctions. Necrosis specific and nonspecific extracellular contrast-enhanced MRI has been used to assess myocardial viability. Contrast-enhanced perfusion MRI can explore the disturbances in large (angiography) and small coronary arteries (myocardial perfusion) as the underlying cause of myocardial dysfunction. Perfusion MRI has been used to measure myocardial perfusion (ml/min/g) and to demonstrate the difference in transmural myocardial blood flow. Information on no-reflow phenomenon is derived from dynamic changes in regional signal intensity after bolus injection of MR contrast agents. Another development is the near future availability of blood pool MR contrast agents. These agents are able to assess microvascular permeability and integrity and are advantageous in MR angiography (MRA) due to their persistence in the blood. Noncontrast-enhanced MRI such as cine MRI at rest/stress, sodium MRI, and MR spectroscopy also have the potential to noninvasively assess myocardial viability in patients. Futuristic applications for MRI in the heart will focus on Identifying coronary artery disease at an early stage and the beneficial effects of new therapeutic agents such as intra-arterial gene therapy. MR techniques will have great future in the drug discovery process and in testing the effects of drugs on myocardial biochemistry, Physiology, and morphology. Molecular imaging is going to bloom In this decade.

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Stress functional MRI: Detection of ischemic heart disease and myocardial viability

Cited by 20 publications

References 43 publications

Cardiac MRI in Ischemic Heart Disease with Severe Coronary Artery Stenosis

Cardiac MRI in Ischemic Heart Disease with Severe Coronary Artery Stenosis

Usefulness of Magnetic Resonance Imaging in Cardiac and Enovascular Intervention

New Concepts in Characterization of Ischemically Injured Myocardium by MRI

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