2020
DOI: 10.3748/wjg.v26.i35.5223
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Stress granules in colorectal cancer: Current knowledge and potential therapeutic applications

Abstract: Stress granules (SGs) represent important non-membrane cytoplasmic compartments, involved in cellular adaptation to various stressful conditions ( e.g ., hypoxia, nutrient deprivation, oxidative stress). These granules contain several scaffold proteins and RNA-binding proteins, which bind to mRNAs and keep them translationally silent while protecting them from harmful conditions. Although the role of SGs in cancer development is still poorly known and vary between cancer types, increasin… Show more

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Cited by 17 publications
(15 citation statements)
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References 190 publications
(225 reference statements)
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“…Because antibodies against G3BP2 and MG53 used for the immunostaining were all derived from rabbits, separate IHCs with G3BP2 and MG53 were conducted with different sections of the xenograft outcomes [26,27,32,[75][76][77]. It has been suggested that interfering with SGs' formation may represent a potential and effective means to enhance the therapy of human cancers [19,21,25,[30][31][32]. Supporting this notion, we performed a xenograft study with A549 cells infected with Ad-TRE-tPA-MG53 to induce the overexpression of MG53 in immune-deficient mice.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Because antibodies against G3BP2 and MG53 used for the immunostaining were all derived from rabbits, separate IHCs with G3BP2 and MG53 were conducted with different sections of the xenograft outcomes [26,27,32,[75][76][77]. It has been suggested that interfering with SGs' formation may represent a potential and effective means to enhance the therapy of human cancers [19,21,25,[30][31][32]. Supporting this notion, we performed a xenograft study with A549 cells infected with Ad-TRE-tPA-MG53 to induce the overexpression of MG53 in immune-deficient mice.…”
Section: Discussionmentioning
confidence: 99%
“…As a result, cancer cells use SGs to support survival and metastatic capacity when exposed to radiotherapy or chemotherapy. Thus, therapeutic approaches that selectively control SG formation might represent a potentially effective means to enhance the treatment of cancer [30][31][32] A recent series of studies from our group identified MG53 (also known as TRIM72) as an important component of cell membrane repair [33][34][35]. Mice with ablation of the MG53 gene develop pathology in multiple tissues and organs due to defective cell membrane repair [33,[36][37][38][39][40].…”
Section: Introductionmentioning
confidence: 99%
“… 68 , 257 P bodies are responsible for RNA decay and storage, and different components of P bodies play different roles in tumorigenesis. 258 Emerging evidence also demonstrates that abnormalities in the expression and/or activity of SG components contribute to drug resistance and the tumorigenesis of diverse cancers, including CRC, 259 pancreatic cancer, 260 and leukemia. 261 Furthermore, YTHDC1 in the nucleus can undergo LLPS by binding with m 6 A-mRNA (Fig.…”
Section: Aberrant Llps In Cancermentioning
confidence: 99%
“…Des essais cliniques ont été réalisés dans différents types de cancers. Ces essais ciblent notamment la voie de signalisation mTOR ou les protéines nécessaires à l'assemblage des GS, comme G3BP1 [45]. À terme, ces composés pourraient être administrés seuls ou conjointement aux agents de chimiothérapie déjà existants, permettant une meilleure prise en charge des patients, avec pour objectif d'améliorer l'efficacité des traitements disponibles.…”
Section: Référencesunclassified