Stress-induced cellular responses in immunogenic cell death: Implications for cancer immunotherapy

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

“…The mechanisms for the preservation of cellular homeostasis in response to infection are also intimately involved in the adjuvanticity of ICD, even when the latter is not driven by microbes. 193 Indeed, multiple nucleic acids of endogenous derivation can be detected by PRRs to initiate danger signalling, generally based on ectopic localization or structural modifications that arise during stress responses. 135 Thus, chemotherapy-driven ICD involves the activation of TLR3 by endogenous RNA species, resulting in type I IFN secretion and the consequent initiation of an autocrine loop that culminates with CXCL10 release.…”

New Hopes for Plasma-Based Cancer Treatment

“…A better understanding of the interactions between cancer cells and the immune system has increased interest in immunotherapies over the last decade [31,32]. Radiation and some chemotherapeutic drugs increase immunogenicity by triggering immunogenic cell death (ICD).…”

C-Type Lectin-Like Receptors: Head or Tail in Cell Death Immunity

“…To conclude, we discussed in this mini review the recent studies that widened the array of identified responses elicited by these receptors and that shed light on the physiological and pathological functions of CLR in response to cell death. By sensing cell death, CLRs seem to protect against potential danger to cellular stress and excessive or deregulated cell death caused by non-infectious or infectious insults (133,134). CLRs can therefore be considered as new immune checkpoint pathways acting as a safeguard to regulate the powerful and potentially harmful immune reactions and to prevent the accidental triggering of responses against the host's own tissues.…”