Stress-induced changes in human salivary alpha-amylase activity—associations with adrenergic activity

Nater, Urs M.; Marca, Roberto La; Florin, Ladina; Moses, Alastair G.W.; Langhans, Wolfgang; Koller, Markus; Ehlert, Ulrike

doi:10.1016/j.psyneuen.2005.05.010

Cited by 530 publications

(448 citation statements)

References 34 publications

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“…In addition, during the first examination, sAA activity was significantly increased in response to the TSST-G. In accordance with our results, others confirmed an increased sAA activity in response to the TSST in individual settings (Nater et al, 2006;Schoofs & Wolf, 2011). The present study replicates and extends results by two previous studies, which tested the TSST-G one time (Childs et al, 2006;von Dawans et al, 2011).…”

supporting

confidence: 93%

“…In line with both previous studies, we found an increase in HR during the TSST-G. In addition, we found a significant decrease in HRV during the TSST-G. Until now, a decrease in HRV during TSST has only been examined during single settings (Nater et al, 2006;Strahler et al, 2010). Our results suggest that the TSST-G induces similar effects regarding psychological, sympathetic nervous system, and parasympathetic nervous system variables as the original single-subject version (e.g.…”

supporting

confidence: 92%

“…Our results suggest that the TSST-G induces similar effects regarding psychological, sympathetic nervous system, and parasympathetic nervous system variables as the original single-subject version (e.g. Kirschbaum et al, 1993;Nater et al, 2006;Strahler et al, 2010).…”

mentioning

confidence: 59%

“…While biomarkers like cortisol (Schoofs & Wolf, 2011;Hellhammer & Schubert, 2012), salivary alpha-amylase (sAA) (Nater et al, 2006;Schoofs & Wolf, 2011), and heart rate (HR) (Nater et al, 2005;Hellhammer & Schubert, 2012) increase, heart rate variability (HRV) decreases in response A c c e p t e d M a n u s c r i p t Boesch et al 04.02.2014 5 to the TSST (Nater et al, 2006;Strahler et al, 2010). Taken together, the TSST is a powerful psychosocial stress task inducing an acute stress response of all main physiologic stress systems.…”

Section: Introductionmentioning

confidence: 99%

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Mood and autonomic responses to repeated exposure to the Trier Social Stress Test for Groups (TSST-G)

Boesch

Sefidan

Ehlert

et al. 2014

Psychoneuroendocrinology

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supporting

confidence: 93%

supporting

confidence: 92%

mentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mood and autonomic responses to repeated exposure to the Trier Social Stress Test for Groups (TSST-G)

Boesch

Sefidan

Ehlert

et al. 2014

Psychoneuroendocrinology

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“…First, we exposed subjects to a valid standardised psychosocial stress condition, the TSST, that was previously shown to reliably evoke profound increases in a variety of physiological parameters (Kirschbaum et al, 1993;Dickerson and Kemeny, 2004;Nater et al, 2006). Second, we classified subjects according to their level of overcommitment, a pattern of excessive striving with documented significance as a psychosocial risk factor of coronary heart disease (Siegrist et al, 1990;Joksimovic et al, 1999;Kuper et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Higher overcommitment to work is associated with lower norepinephrine secretion before and after acute psychosocial stress in men

Wirtz

Siegrist

Rimmele

et al. 2008

Psychoneuroendocrinology

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Higher overcommitment to work is associated with lower norepinephrine secretion before and after acute psychosocial stress in men Higher overcommitment to work is associated with lower norepinephrine secretion before and after acute psychosocial stress in men Abstract BACKGROUND: Overcommitment (OC) is a pattern of excessive striving. In reaction to work stress, OC has been associated with higher sympathetic nervous system activation and cortisol release, but data on neuroendocrine reactivity to standardized stressors are scarce. We investigated whether OC is associated with differential levels of the stress hormones norepinephrine and cortisol in response to acute psychosocial stress.METHODS: Fifty-eight medication-free non-smoking men aged between 20 and 65 years (mean+/-S.E.M.: 36.3+/-1.8) underwent an acute standardized psychosocial stress task combining public speaking and mental arithmetic in front of an audience. We assessed OC as well as a variety of psychological control variables including vital exhaustion, perfectionism, chronic stress, and cognitive stress appraisal. Moreover, we measured plasma norepinephrine as well as salivary cortisol before and after stress and several times up to 60 min thereafter.RESULTS: Higher OC was associated with lower baseline norepinephrine levels (r = -0.37, p < 0.01). General linear models controlling for age, BMI, and mean arterial blood pressure revealed that higher overcommitment was associated with lower norepinephrine and cortisol levels before and after stress (p's < 0.02) as well as with lower norepinephrine stress reactivity (p = 0.02). Additional controlling for the potential psychological confounders vital exhaustion, perfectionism, chronic stress, and depression confirmed lower norepinephrine levels before and after stress (p < 0.01) as well lower norepinephrine stress reactivity (p = 0.02) with increasing OC. Higher OC independently explained 13% of the total norepinephrine stress response (beta = -0.46, p < 0.01, R(2) change = 0.13).CONCLUSIONS: Our findings suggest blunted increases in norepinephrine following stress with increasing OC potentially mirroring blunted stress reactivity of the sympathetic nervous system. ABSTRACTBackground: Overcommitment is a pattern of excessive striving. In reaction to work stress, overcommitment (OC) has been associated with higher sympathetic nervous system activation and cortisol release, but data on neuroendocrine reactivity to standardized stressors are scarce. We investigated whether overcommitment is associated with differential levels of the stress hormones norepinephrine and cortisol in response to acute psychosocial stress.Methods: 58 medication-free non-smoking men aged between 20 and 65 years (mean±SEM: 36.3±1.8) underwent an acute standardized psychosocial stress task combining public speaking and mental arithmetic in front of an audience. We assessed overcommitment as well as a variety of psychological control variables including vital exhaustion, perfectionism, chronic stress, and cognitive stress appraisa...

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How stress contributes to autoimmunity—lessons from Sjögren's syndrome

Skopouli

Katsiougiannis²

2017

FEBS Letters

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A large body of clinical evidence on the association between stressful life events and autoimmune diseases suggests that stress may play an important role in the pathogenesis of these disorders. In this article, we discuss the effects of stress, not on the immune system but on specific cell populations against which the autoimmune reactivity is directed. Using Sj€ ogren's syndrome as a model autoimmune disease, we review the role of stress in the initiation and perpetuation of autoimmune reactivity. We present data that reveal the effects of stress on salivary gland epithelial cells, suggesting that stress can become immunogenic through its various effects on salivary gland epithelium.

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Stress-induced changes in human salivary alpha-amylase activity—associations with adrenergic activity

Cited by 530 publications

References 34 publications

Mood and autonomic responses to repeated exposure to the Trier Social Stress Test for Groups (TSST-G)

Mood and autonomic responses to repeated exposure to the Trier Social Stress Test for Groups (TSST-G)

Higher overcommitment to work is associated with lower norepinephrine secretion before and after acute psychosocial stress in men

How stress contributes to autoimmunity—lessons from Sjögren's syndrome

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