Stress-induced changes in sleep and associated neuronal activity in rat hippocampus and amygdala

Hegde, Preethi; Singh, Kulvir; Chaplot, S.; Rao, B.S. Shankaranarayana; Chattarji, Sumantra; Kutty, Bindu M.; Laxmi, T. Rao

doi:10.1016/j.neuroscience.2008.01.042

Cited by 32 publications

(19 citation statements)

References 71 publications

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“…basolateral and lateral amygdala during REM sleep in rats, which are consistent with previous reports (Hegde et al 2008;Paré and Gaudreau 1996). Although the regional theta waves had slightly different dynamics from their other characteristics, the cross-correlation function between the hippocampal and amygdala field potentials showed that the two regional potentials were synchronized and in-phase in the theta frequency range, which are consistent with previous results in rats and cats (Hegde et al 2008;Paré and Gaudreau 1996).…”

Section: Discussionsupporting

confidence: 92%

“…Although the regional theta waves had slightly different dynamics from their other characteristics, the cross-correlation function between the hippocampal and amygdala field potentials showed that the two regional potentials were synchronized and in-phase in the theta frequency range, which are consistent with previous results in rats and cats (Hegde et al 2008;Paré and Gaudreau 1996). The characteristics of theta synchronization during REM sleep were similar to those during wakefulness, as previously shown by Seidenbecher et al (2003).…”

Section: Discussionsupporting

confidence: 90%

“…In this study, we first confirmed that theta waves in the basolateral/lateral amygdala are synchronized with theta waves in the hippocampal CA1 region during REM sleep, as reported by Hegde et al (2008) and Paré and Gaudreau (1996). Next, we studied how P waves are temporally correlated with synchronized hippocampal and amygdala theta waves.…”

Section: Introductionsupporting

confidence: 80%

“…However, it is not known what functions may be underlain by such a cooperative relationship between regional theta waves. In addition, it is not clear how P wave activity modifies the dynamics of theta rhythms in the amygdala and the cooperation between regional theta waves.In this study, we first confirmed that theta waves in the basolateral/lateral amygdala are synchronized with theta waves in the hippocampal CA1 region during REM sleep, as reported by Hegde et al (2008) and Paré and Gaudreau (1996). Next, we studied how P waves are temporally correlated with synchronized hippocampal and amygdala theta waves.…”

supporting

confidence: 80%

“…The physiological significance of this input has been suggested in the context of learning and memory processes during REM sleep (Datta et al 2008). One of the intriguing features of theta waves in the amygdala during REM sleep is the synchronization with theta waves in the hippocampus (Hegde et al 2008;Paré and Gaudreau 1996). However, it is not known what functions may be underlain by such a cooperative relationship between regional theta waves.…”

Section: Introductionmentioning

confidence: 99%

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Enhancement of Synchronization Between Hippocampal and Amygdala Theta Waves Associated With Pontine Wave Density

Karashima

Katayama

Nakao

2010

Journal of Neurophysiology

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Karashima A, Katayama N, Nakao M. Enhancement of synchronization between hippocampal and amygdala theta waves associated with pontine wave density. J Neurophysiol 103: 2318 -2325, 2010. First published February 17, 2010 doi:10.1152/jn.00551.2009. Theta waves in the amygdala are known to be synchronized with theta waves in the hippocampus. Synchronization between amygdala and hippocampal theta waves is considered important for neuronal communication between these regions during the memory-retrieval process. These theta waves are also observed during rapid eye movement (REM) sleep. However, few studies have examined the mechanisms and functions of theta waves during REM sleep. This study examined correlations between the dynamics of hippocampal and amygdala theta waves and pontine (P) waves in the subcoeruleus region, which activates many brain areas including the hippocampus and amygdala, during REM sleep in rats. We confirmed that the frequency of hippocampal theta waves increased in association with P wave density, as shown in our previous study. The frequency of amygdala theta waves also increased with in associated with P wave density. In addition, we confirmed synchronization between hippocampal and amygdala theta waves during REM sleep in terms of the crosscorrelation function and found that this synchronization was enhanced in association with increased P wave density. We further studied theta wave synchronization associated with P wave density by lesioning the pontine subcoeruleus region. This lesion not only decreased hippocampal and amygdala theta frequency, but also degraded theta wave synchronization. These results indicate that P waves enhance synchronization between regional theta waves. Because hippocampal and amygdala theta waves and P waves are known to be involved in learning and memory processes, these results may help clarify these functions during REM sleep. I N T R O D U C T I O NHippocampal theta waves are rhythmic field potentials recorded during particular behavioral activities and rapid eye movement (REM) sleep in cats and rats (Louie and Wilson 2001;Montgomery et al. 2008). The pontine reticular formation (PRF) nuclei, which have ascending projections to the septum/hippocampus via the diencephalon, are involved in the generation of hippocampal theta waves (Bland and Oddie 1998). During REM sleep, a group of PRF neurons begins to fire and/or increase their discharge rate coincident with the phasic field potential, which is called the ponto-geniculooccipital (PGO) wave in cats (Datta 1997;Koyama and Sakai 2000). In rats, a PGO-like phasic potential called the pontine (P) wave can be recorded in the subcoeruleus region (Datta et al. 1998;Heister et al. 2007), which has mutual connections with the other PRF (Datta et al. 1998(Datta et al. , 1999. Our previous studies on the relationships between PGO/P waves and theta waves during REM sleep have shown that an increase in the frequency of theta waves coincides with an increase in PGO wave density in cats and P wave density in rats (Karashima...

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Introductionsupporting

confidence: 80%

supporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

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Enhancement of Synchronization Between Hippocampal and Amygdala Theta Waves Associated With Pontine Wave Density

Karashima

Katayama

Nakao

2010

Journal of Neurophysiology

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Does Stress Elicit Depression? Evidence From Clinical and Preclinical Studies

Sickmann

Yan

Mørk

et al. 2014

Behavioral Neurobiology of Stress-Related Disorders

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Exposure to stressful situations may induce or deteriorate an already existing depression. Stress-related depression can be elicited at an adolescent/adult age but evidence also shows that early adverse experiences even at the fetal stage may predispose the offspring for later development of depression. The hypothalamus-pituitary-adrenal axis (HPA-axis) plays a key role in regulating the stress response and dysregulation in the system has been linked to depression both in humans and in animal models. This chapter critically reviews clinical and preclinical findings that may explain how stress can cause depression, including HPA-axis changes and alterations beyond the HPA-axis. As stress does not elicit depression in the majority of the population, this motivated research to focus on understanding the biology underlying resilient versus sensitive subjects. Animal models of depression have contributed to a deeper understanding of these mechanisms. Findings from these models will be presented.

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Expression patterns of c-Fos early gene and phosphorylated ERK in the rat brain following 1-h immobilization stress: concomitant changes induced in association with stress-related sleep rebound

et al. 2014

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An immobilization stress (IS) of 1 h applied at the beginning of the dark phase is followed by a sleep rebound. During the restraint, serotonin released by the dorsal raphe nucleus within the arcuate area stimulates the availability of corticotropin-like intermediate lobe peptide (CLIP or ACTH18-39). Three hours after the restraint, CLIP, through its hypnogenic properties, contributes to the sleep rebound that follows the IS. Here, we immunohistochemically evaluated protein expression of the immediate early gene, c-Fos and phosphorylated extracellular signal-regulated kinase (p-ERK) in hypothalamic (preoptic area [POA], paraventricular nucleus [PVN], arcuate nucleus [ARC]) and brain stem (dorsal raphe [DR], locus coeruleus [LC]) nuclei involved in the acute response to stress and the subsequent stress-related sleep rebound (recovery period). Immediately after the 1-h restraint, c-Fos and p-ERK expression increased in all structures studied, particularly in PVN and LC. Three hours later, the number of p-ERK- and c-Fos-positive neurons was reduced in PVN and LC (p < 0.001) as well as in DR (p < 0.01) compared to control animals. In contrast, both c-Fos and p-ERK expression in POA neurons (p < 0.01) and c-Fos expression in ARC neurons (p < 0.001) were increased 3 h after the IS. The marked activation observed in PVN and LC nucleus immediately after the IS confirms that these structures are clearly reactive to stress. However, the high activity observed in POA and ARC neurons during the recovery period, not described to date, highlights the particular part played by these structures in the stress-related sleep rebound. An unbalance in the above processes may contribute to pathological outcomes, such as anxiety and depression.

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Stress-induced changes in sleep and associated neuronal activity in rat hippocampus and amygdala

Cited by 32 publications

References 71 publications

Enhancement of Synchronization Between Hippocampal and Amygdala Theta Waves Associated With Pontine Wave Density

Enhancement of Synchronization Between Hippocampal and Amygdala Theta Waves Associated With Pontine Wave Density

Does Stress Elicit Depression? Evidence From Clinical and Preclinical Studies

Expression patterns of c-Fos early gene and phosphorylated ERK in the rat brain following 1-h immobilization stress: concomitant changes induced in association with stress-related sleep rebound

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