Stress-induced cross-sensitization to amphetamine is related to changes in the dopaminergic system

Cruz, Fábio C.; Marin, Marcelo Tadeu; Leão, Rodrigo M.; Planeta, Cleópatra da Silva

doi:10.1007/s00702-011-0720-8

Cited by 27 publications

(22 citation statements)

References 52 publications

(60 reference statements)

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“…Further, there was a significant positive association between the increases in cortisol and DA. These findings converge with previous studies on the relation of glucocorticoids and DA in animal models (Cruz et al, 2012), as well as experimental research with healthy human subjects (Walker et al, 2008). …”

Section: The Hpa Axis and Chrsupporting

confidence: 92%

Stress and neurodevelopmental processes in the emergence of psychosis

et al. 2013

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The notion that stress plays a role in the etiology of psychotic disorders, especially schizophrenia, is longstanding. However, it is only in recent years that the potential neural mechanisms mediating this effect have come into sharper focus. The introduction of more sophisticated models of the interplay between psychosocial factors and brain function has expanded our opportunities for conceptualizing more detailed psychobiological models of stress in psychosis. Further, scientific advances in our understanding of adolescent brain development have shed light on a pivotal question that has challenged researchers; namely, why the first episode of psychosis typically occurs in late adolescence/young adulthood. In this paper, we begin by reviewing the evidence supporting associations between psychosocial stress and psychosis in diagnosed patients as well as individuals at clinical high risk for psychosis. We then discuss biological stress systems and examine changes that precede and follow psychosis onset. Next, research findings on structural and functional brain characteristics associated with psychosis are presented; these findings suggest that normal adolescent neuromaturational processes may go awry, thereby setting the stage for the emergence of psychotic syndromes. Finally, a model of neural mechanisms underlying the pathogenesis of psychosis is presented and directions for future research strategies are explored.

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Section: The Hpa Axis and Chrsupporting

confidence: 92%

Stress and neurodevelopmental processes in the emergence of psychosis

et al. 2013

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“…It was predicted that, similar to previous studies with amphetamine, chronic stress would result in increased METH-induced locomotor activity (Antelman et al, 1980, Deroche et al, 1992, Cruz et al, 2011). Instead, rats exposed to CVS exhibited an initial reduction (i.e., first 10 minutes following administration) of the locomotor stimulating effects of METH (Figure 5).…”

Section: Discussionsupporting

confidence: 60%

Chronic stress may facilitate the recruitment of habit- and addiction-related neurocircuitries through neuronal restructuring of the striatum

et al. 2014

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Chronic stress is an established risk factor in the development of addiction. Addiction is characterized by a progressive transition from casual drug use to habitual and compulsive drug use. The ability of chronic stress to facilitate the transition to addiction may be mediated by increased engagement of the neurocircuitries underlying habitual behavior and addiction. In the present study, striatal morphology was evaluated after two weeks of chronic variable stress in male Sprague-Dawley rats. Dendritic complexity of medium spiny neurons was visualized and quantified with Golgi staining in the dorsolateral and dorsomedial striatum, as well as in the nucleus accumbens core and shell. In separate cohorts, the effects of chronic stress on habitual behavior and the acute locomotor response to methamphetamine were also assessed. Chronic stress resulted in increased dendritic complexity in the dorsolateral striatum and nucleus accumbens core, regions implicated in habitual behavior and addiction, while decreased complexity was found in the nucleus accumbens shell, a region critical for the initial rewarding effects of drugs of abuse. Chronic stress did not affect dendritic complexity in the dorsomedial striatum. A parallel shift toward habitual learning strategies following chronic stress was also identified. There was an initial reduction in acute locomotor response to methamphetamine, but no lasting effect as a result of chronic stress exposure. These findings suggest that chronic stress may facilitate the recruitment of habit- and addiction-related neurocircuitries through neuronal restructuring in the striatum.

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“…Similarly, a study by Cunningham et al found that rats who were given intra-accumbens treatment of certain opiates (such as morphine) later proved to be sensitized to the behavioral effects of amphetamine (Cunningham and Kelley 1992;Leyton 2007). Cross-sensitization and resulting hyper-responsivity of dopaminergic systems also occurs between drugs of abuse and natural rewards (Avena and Hoebel 2003a) and drugs of abuse and stress (at both behavioral and physiological levels) (Piazza et al 1990;Cruz et al 2011;Garcia-Keller et al 2013). This latter finding highlights the important role that stress may play in relapse, whereby stressful life events can act as powerful triggers of drug cravings and a history of stressful life events may even predispose a person to drug addiction.…”

Section: Evidence For the Incentive Sensitization Theorymentioning

confidence: 98%

Roles of “Wanting” and “Liking” in Motivating Behavior: Gambling, Food, and Drug Addictions

Robinson

Fischer

Ahuja

et al. 2015

Current Topics in Behavioral Neurosciences

213

151

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The motivation to seek out and consume rewards has evolutionarily been driven by the urge to fulfill physiological needs. However in a modern society dominated more by plenty than scarcity, we tend to think of motivation as fueled by the search for pleasure. Here, we argue that two separate but interconnected subcortical and unconscious processes direct motivation: "wanting" and "liking." These two psychological and neuronal processes and their related brain structures typically work together, but can become dissociated, particularly in cases of addiction. In drug addiction, for example, repeated consumption of addictive drugs sensitizes the mesolimbic dopamine system, the primary component of the "wanting" system, resulting in excessive "wanting" for drugs and their cues. This sensitizing process is long-lasting and occurs independently of the "liking" system, which typically remains unchanged or may develop a blunted pleasure response to the drug. The result is excessive drug-taking despite minimal pleasure and intense cue-triggered craving that may promote relapse long after detoxification. Here, we describe the roles of "liking" and "wanting" in general motivation and review recent evidence for a dissociation of "liking" and "wanting" in drug addiction, known as the incentive sensitization theory (Robinson and Berridge 1993). We also make the case that sensitization of the "wanting" system and the resulting dissociation of "liking" and "wanting" occurs in both gambling disorder and food addiction.

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Stress-induced cross-sensitization to amphetamine is related to changes in the dopaminergic system

Cited by 27 publications

References 52 publications

Stress and neurodevelopmental processes in the emergence of psychosis

Stress and neurodevelopmental processes in the emergence of psychosis

Chronic stress may facilitate the recruitment of habit- and addiction-related neurocircuitries through neuronal restructuring of the striatum

Roles of “Wanting” and “Liking” in Motivating Behavior: Gambling, Food, and Drug Addictions

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