Stress-induced generalization of negative memories is mediated by an extended hippocampal circuit

Ren, Lynn Y.; Meyer, Mariah A.A.; Grayson, Viktoriya S; Gao, Pan; Guedea, Anita L.; Radulović, Jelena

doi:10.1038/s41386-021-01174-4

Cited by 13 publications

(4 citation statements)

References 68 publications

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“…The enhancing effect of acute stress on the generalization of fear (i.e., US expectancies) described in Chapter 3 align well with previous studies that observed an acute stress or cortisol effect on fear generalization in humans (e.g., and animals (e.g., Bender et al, 2018;Kaouane et al, 2012;Kolodziejczyk & Fendt, 2020;Lesuis et al, 2021;Liu et al, 2019;Ren et al, 2022;Zhu et al, 2018). However, a recent study failed to find an effect of acute stress on fear generalization in healthy individuals (Kausche, Zerbes, Kampermann, Büchel, et al, 2021).…”

Section: The Effect Of Stress On Fear and Avoidancesupporting

confidence: 84%

Rethinking avoidance

Lemmens¹

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Section: The Effect Of Stress On Fear and Avoidancesupporting

confidence: 84%

Rethinking avoidance

Lemmens¹

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“…Fear generalization to cues that do not predict threat may be promoted by elevations in hippocampal corticosterone ( 29, 30 ) and accompanied by altered hippocampal function in female rodents ( 31, 32 ). Contextual fear generalization can also be induced by NSV and is mediated by extended circuitry to and from the dorsal hippocampus ( 33 ). Previous findings using the same NSV social defeat model in female mice suggested that resulting hypervigilance, demonstrated as an exaggeration in defensive behaviors towards neutral mice, may underlie the inability to discriminate threatening from non-threatening social targets ( 13 ).…”

Section: Discussionmentioning

confidence: 99%

Social valence dictates sex differences in identity recognition

Larosa,

Xu,

Wong

et al. 2024

Preprint

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Social valence is the directional emotional significance affiliated with social experiences. Maladaptive processing of negative social valence (NSV) has been linked to mood disorder susceptibility, which is more prevalent in women. To determine whether there are sex differences in NSV processing, we developed social valence tasks where the identity recognition of conspecifics with distinct valences served as the readout. Male mice demonstrated identity recognition regardless of social valence. Conversely, female mice did not show identity recognition following the NSV task.In vivocalcium imaging of the dorsal CA1 further revealed sex differences in NSV processing with reduced hippocampal representation of social information in female mice. These results suggest the imprecise encoding of NSV may contribute to the heightened vulnerability to social stress-related mood disorders in women.

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“…Cognitive overgeneralisation is a consistent cognitive phenotype observed in individuals with depression (Ren et al, 2022 ). It occurs in various cognitive domains, including overgeneral thinking and overgeneral memory.…”

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confidence: 82%

Cognitive factors as mediators of the relationship between childhood trauma and depression symptoms: the mediating roles of cognitive overgeneralisation, rumination, and social problem-solving

Dehghan Manshadi,

Neshat-Doost,

Jobson

2024

European Journal of Psychotraumatology

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Background: Childhood trauma has negative immediate and long-term impacts on depression. Questions remain, however, regarding the cognitive factors influencing this relationship. This study aimed to investigate the role of three cognitive factors – cognitive overgeneralisation, rumination and social problem-solving – as mediating factors in the relationship between childhood trauma and symptoms of depression. Methods: We conducted a cross-sectional study in Iran from March to July 2023. Participants ( N = 227; Mean age 32.44 ± 8.95 years) with depression completed measures of childhood trauma, depression, self-overgeneralisation, cognitive errors, memory specificity, rumination and social problem-solving. The conceptual model was assessed using structural equation modelling. Results: Structural equation modelling indicated that childhood trauma had a positive direct effect on depression symptoms. Childhood trauma had a positive indirect effect on depression symptoms through both self-overgeneralisation and rumination and a negative indirect effect on depression through effective social problem-solving strategies. Conclusions: The findings suggest increased exposure to childhood trauma may be associated with elevated depression and self-overgeneralisation, rumination, and effective social problem-solving strategies may play an important role in this relationship. These findings hold potential implications for those working with patients with depression and a history of childhood trauma.

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Stress-induced generalization of negative memories is mediated by an extended hippocampal circuit

Cited by 13 publications

References 68 publications

Rethinking avoidance

Rethinking avoidance

Social valence dictates sex differences in identity recognition

Cognitive factors as mediators of the relationship between childhood trauma and depression symptoms: the mediating roles of cognitive overgeneralisation, rumination, and social problem-solving

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