2005
DOI: 10.1016/j.bbalip.2004.12.016
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Stress-induced platelet-activating factor synthesis in human neutrophils

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Cited by 21 publications
(23 citation statements)
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References 47 publications
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“…Supporting this hypothesis, we have previously shown that acidic conditions induce neutrophil activation by a mechanism dependent on the stimulation of PI3K/Akt and ERK pathways (43,52). Consistent with these results, Owen et al (53) have recently shown that exposure of human neutrophils to low pH values results in the production of platelet-activating factor, a strong inflammatory stimulus. Interestingly, it has also been shown that extracellular acidosis efficiently activates the alternative pathway of complement (54,55).…”
Section: Discussionsupporting
confidence: 68%
“…Supporting this hypothesis, we have previously shown that acidic conditions induce neutrophil activation by a mechanism dependent on the stimulation of PI3K/Akt and ERK pathways (43,52). Consistent with these results, Owen et al (53) have recently shown that exposure of human neutrophils to low pH values results in the production of platelet-activating factor, a strong inflammatory stimulus. Interestingly, it has also been shown that extracellular acidosis efficiently activates the alternative pathway of complement (54,55).…”
Section: Discussionsupporting
confidence: 68%
“…They could be related to the different experimental conditions used in each study. For example, Owen et al (61) conducted their experiments using neutrophils suspended in a serum-free modified HBSS supplemented with Tris, histidine, acetic acid, and lactic acid, whereas all of our experiments were performed in RPMI 1640 medium supplemented with 1% heat-inactivated FCS.…”
Section: Discussionmentioning
confidence: 99%
“…(61) have recently shown that exposure of human neutrophils to extracellular acidosis results in a marked increase in the synthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine). The maximum increase was found at pH 5.4, but a significant enhancement was also observed at pH 6.4, a value of extracellular pH similar to the one we used throughout our study (pH 6.5).…”
Section: Discussionmentioning
confidence: 99%
“…1). The latter pathway is primarily involved in the synthesis of PAF by stimulated inflammatory cells such as murine peritoneal cells (3,4) and human granulocytes (5). The initiation of the remodeling pathway requires membrane phospholipid hydrolysis by phospholipase A 2 s (PLA 2 ; EC 3.1.1.4) that supply lyso-PAF, a precursor of PAF.…”
Section: Platelet-activating Factor Production In the Spinal Cord Of mentioning
confidence: 99%