The influence of stress state on fatigue crack growth in nickel‐base superalloys at high temperature is considered, based on studies in corner crack specimens of Inconel 718 at 600 °C. At high frequency and low R, cycle‐dependent trans‐granular crack growth occurs along the whole crack front, and growth rates are similar at the surface and within the interior of specimens, maintaining the original quarter‐circular shape. For conditions of low frequency and high R, increased crack growth rate per cycle is observed with the crack tunnelling ahead at the centre. A time‐dependent intergranular crack propagation mode occurs in the plane strain interior, attributed to an oxidation mechanism, whereas near the surfaces under plane stress, a trans‐granular cyclic plasticity mechanism is observed. It is proposed that in addition to frequency and R, that stress state influences the competition between the mechanisms controlling crack growth and the transition between them: plane strain in the interior favouring an oxidation‐controlled intergranular cracking mechanism as compared with the plane stress surfaces where cyclic plasticity dominates. An FEM study suggests that this influence of stress state is not associated with variation of ΔK along the crack front.