W e know that the vasomotor system, which regulates the capillary circulation, is much influenced by the mind.
-Charles Darwin, Expression of the Emotions in Man and AnimalsThe practice of medicine today is in need of transformation. The majority of diseases plaguing modern society are initiated by unhealthy lifestyle choices or events, often taking many years to develop and mature to a stage where symptoms and signs become manifest. It is only at this typically advanced stage that the healthcare system initially becomes engaged. Although many diagnoses share a common lifestyle-related etiology, we treat the silos of diagnoses with a growing list of pharmacotherapies, each targeting a single disease process, or invasively with repeated and often palliative procedures such as stents or bypass surgeries. Verbal recommendations are generally provided to our patients to curb poor lifestyle habits, but minimal investment is put forward by the healthcare industry to create an environment where successful lifestyle change can be effected. Of the many lifestyle events that impact our patients, none is more ubiquitous than stress and stress-related conditions.The global impact of stress-related conditions is expected to rise over this decade such that by 2020, depression and anxiety disorders, including stress-related health conditions, will be second only to ischemic heart disease in prevalence. 1 Although stress can occur at home or after trauma, the most ubiquitous and studied form of stress is work related. In this context, stress has been defined as an emotional experience associated with nervousness, tension, and strain. 2,3 In the workplace, stress and performance describe a U-shaped relationship such that low-to-moderate levels of stress generate a positive performance, whereas a negative performance is created at moderate-to-high levels of stress. 2,4 As a result, several studies, including many funded by the National Institute of Occupational Safety and Health, have documented the negative health and financial consequences of job stress. In addition to its impact on health, job-related stress has been shown to increase the cost of doing business by as much as $150 billion per year because of higher levels of absenteeism, worker's compensation claims, accidents, customer service problems, resistance to change, litigation, and loss of intellectual capital. 2 The health consequences of job stress impact most organ systems, including musculoskeletal disorders, psychological disease (ie, depression, burnout, and suicide), workplace injury, gastrointestinal disorders including ulcers, headaches, obesity, and sleep disturbances. By far and away, however, the most common and studied linkage related to stress and health is that from cardiovascular disease, which alone accounts for an estimated $117 billion per year in lost productivity and treatment because of job-related stress. 2 The INTERHEART Study evaluated cardiovascular risk factors in 29 972 people from 52 countries to investigate risk of first myocardial infarc...