Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice

Béracochéa, Daniel; Liscia, Pierrette; Tronche, Christophe; Chauveau, Frédéric; Jouanin, Jean-Claude; Piérard, Christophe

doi:10.1007/s00213-007-0915-8

Cited by 18 publications

(17 citation statements)

References 45 publications

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“…The CSD task has been extensively described in earlier studies (see Celerier et al, 2004;Beracochea et al, 2008;Chauveau et al, 2008). All tests were performed in a four-hole board apparatus (45 cm 3 45 cm 3 30 cm high) enclosed by gray Plexiglas.…”

Section: Apparatusmentioning

confidence: 99%

Rapid stress‐induced corticosterone rise in the hippocampus reverses serial memory retrieval pattern

Chauveau

Tronche

Piérard³

et al. 2009

Hippocampus

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We previously showed that an acute stress (electric footshocks) induced both a rapid plasma corticosterone rise and a reversal of serial memory retrieval pattern in a contextual serial discrimination (CSD) task. This study is aimed at determining (i) if the rapid stress effects on CSD performance are mediated by the hippocampus; (ii) if hippocampal corticosterone membrane receptor activation is involved in the rapid stress effects on CSD performance. In experiment 1, microdialysis in the dorsal hippocampus (dHPC) was used to measure the stress-induced corticosterone rise; in parallel, the effect of acute stress on CSD performance was evaluated. In addition, the functional involvement of corticosterone in the behavioral effects of stress was assessed by administering metyrapone, a corticosterone synthesis inhibitor, before stress. In experiment 2, the involvement of hippocampal corticosterone membrane receptors in the stress-induced reversal of CSD performance was studied by injecting corticosterone-bovine serum albumin (BSA) (a membrane-impermeable complex) in the dHPC in non stressed mice. Results showed that (i) the acute stress induced a rapid (15 min) and transitory (90 min) corticosterone rise into the hippocampus dHPC, and a reversal of serial memory retrieval pattern; (ii) both the endocrinal and memory stress-induced effects were blocked by metyrapone; (iii) corticosterone-BSA injection into the dHPC in non stressed mice mimicked the effects of stress on serial retrieval pattern. Overall, our study is first to show that (i) a rapid stress-induced corticosterone rise into the dHPC transitorily reverses serial memory retrieval pattern and (ii) hippocampal corticosterone membrane receptors activation is involved in the rapid effects of acute stress on serial memory retrieval.

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Section: Apparatusmentioning

confidence: 99%

Rapid stress‐induced corticosterone rise in the hippocampus reverses serial memory retrieval pattern

Chauveau

Tronche

Piérard³

et al. 2009

Hippocampus

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“…Indeed, the choice of the CSD task will allow a comparison with a recent study involving modafinil-treated mice in the very same task (Béracochéa et al 2008). Overall, animals were submitted to the acquisition phase of the CSD task (learning of D1 and D2 discriminations on two different floors) as previously described.…”

Section: Experiments 2: Serial Discriminationmentioning

confidence: 99%

“…1 and has been described in full elsewhere (Célérier et al 2004b;Béracochéa et al 2004Béracochéa et al , 2008.…”

Section: Amphetamine Injectionmentioning

confidence: 99%

“…Indeed, we already validated both behavioral tasks since we previously showed: (1) that a physiological stress specifically affected retrieval memory processes in the CSD and in the SD tasks (Célérier et al 2004a, b) and (2) that these effects of stress on retrieval were modulated by the vigilance-enhancing drug modafinil. Indeed, we found that this compound was able to enhance contextual serial memory retrieval in a dose-dependent manner, via an interaction with glucocorticoids secretion (Béracochéa et al 2008).…”

Section: Introductionmentioning

confidence: 98%

“…In parallel, plasma corticosterone levels were determined, as we previously performed for modafinil (Béracochéa et al 2008).…”

Section: Introductionmentioning

confidence: 99%

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Combined effects of acute stress and amphetamine on serial memory retrieval pattern in mice

Piérard¹,

Tronche

Liscia³

et al. 2008

Psychopharmacology

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Results showed that: (1) vehicle group expressed in both tasks a similar memory retrieval pattern, D2 being better retrieved than D1; (2) 2 mg/kg amphetamine significantly enhanced D1 but not D2 performance in both tasks, whereas 4 mg/kg amphetamine enhanced D2 but not D1 retrieval. Thus, amphetamine more specifically modulates serial order memory retrieval in a context-independent manner. In a further step, we studied the effect of an acute stress (electric foot shocks 5 min before retrieval) specifically on D1 performance of the CSD task in 2 mg/kg amphetamine-treated mice. Immediately after testing, blood was sampled to measure plasma corticosterone levels. Results showed that acute stress significantly improved D1 performance in vehicles but blocked the memory-enhancing effect of 2 mg/kg amphetamine, as compared to the nonstress condition. However, statistical analysis failed to evidence a significant interaction between treatments and conditions (stress vs nonstress) on corticosterone levels, contrary to another vigilance-enhancing drug, modafinil (Béracochéa, Psychopharmacology 196:1-13, 2008).

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Depression-like deficits in rats improved by subchronic modafinil

et al. 2009

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Stress modulation of the memory retrograde-enhancing effects of the awakening drug modafinil in mice

Cited by 18 publications

References 45 publications

Rapid stress‐induced corticosterone rise in the hippocampus reverses serial memory retrieval pattern

Rapid stress‐induced corticosterone rise in the hippocampus reverses serial memory retrieval pattern

Combined effects of acute stress and amphetamine on serial memory retrieval pattern in mice

Depression-like deficits in rats improved by subchronic modafinil

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