Stress procedures lowering body temperature augment gastric motility by increasing the sensitivity to acetylcholine in rats.

Yano, Shingo; Matsukura, Hitoshi; Shibata, Masahiro; Harada, Masatoshi

doi:10.1248/bpb1978.5.582

Cited by 13 publications

(4 citation statements)

References 17 publications

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“…There fore, it seems plausible to consider that stress and not REMd per se was the responsible of the described effects. Yano et al [ 1982] reported that two other forms of stress, namely immobilization and water immersion, produced an increased gastric motility in rats injected with acetyl choline and bethancchol, which would indi cate an up regulation of cholinergic receptors located in the stomach. Therefore, it is possi ble that either different forms of stress are able to produce opposite effects in peripheral cholinergic receptors or, alternatively, that these receptors react differently to stress de pending upon their location in the organism.…”

Section: Discussionmentioning

confidence: 99%

Red Lacrimal Secretion (Chromodacryorrhea) Induced by Cholinergic Drugs in Rats Subjected to the Watertank Technique

Santos

Carlini

1988

Pharmacology

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Red tears (chromodacryorrhea) in rats are due to porphyrin pigments secreted by Harder’s glands and are believed to involve muscarinic mechanisms. Chromodacryorrhea was observed in rats treated with pilocarpine, oxotremorine and neostigmine and this response was blocked by anticholinergic drugs. However, in rats deprived of rapid eye movement (REM) sleep (REMd) for 3 days, through the watertank technique, chromodacryorrhea did not develop even when cholinergic agonists were given in doses severalfold higher than those active in non-REMd animals. Decrease of chromodacryorrhea also was obtained in rats previously treated with neostigmine; conversely, previous treatment with atropine induced an increased chromodacryorrhea when the rats were further challenged with pilocarpine and oxotremorine. It is proposed that the absence of red tears in REMd rats might be due to a down regulation of peripheral cholinergic receptors

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Section: Discussionmentioning

confidence: 99%

Red Lacrimal Secretion (Chromodacryorrhea) Induced by Cholinergic Drugs in Rats Subjected to the Watertank Technique

Santos

Carlini

1988

Pharmacology

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“…It is acknowledged that stress modulates gastrointestinal motility (198,206). Gastric emptying, small intestine transit, large intestine transit, and faecal output have been reported to be affected in rats by stress, but different responses have been described depending on the stress stimulus.…”

Section: Effects Of Stress On the Intestinementioning

confidence: 99%

“…HRS is more efficient than either CS or RS alone in inducing gastric lesions, changes in gastric somatostatin or thyrotropin releasing hormone (TRH), and acid secretion (125), The difference between HRS and RS is based on the change in blood viscosity brought about by hypothermia, Thus rats exposed to HRS or hypothermia + anaesthesia develop comparable gastric lesions (122). In addition, hypothermia may sensitize the muscle layers in the stomach to acetylcholine (206). On the other hand, it is important to note that the combination of hypothermia and anaesthesia may cause augmented acid secretion and motility plus diminished bicarbonate secretion (185).…”

mentioning

confidence: 99%

Effect of psychogenic stress on gastrointestinal function

Medina

2000

J Physiol Biochem

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This review summarizes the studies published over the last twenty years on the effects of psychogenic stress on gastrointestinal function, using animal models. The effects of stress on gastric ulceration have received wide attention and the central and local mechanisms of mucosal damage have been, for the most part, clearly delineated. In comparison, relatively few studies have focused on the impact of stress on intestinal and colonic physiology, even though its influence on intestinal motility, mucosal permeability and inflammation has been established. More work is necessary in this field, especially considering the importance of irritable bowel syndrome in modern society.

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“…The slow contractions are produced by lowering the body temperature (55) during cold restraint (52,56) with predictable and unpredictable electric shocks (40), and in the restrained, prematurely separated, 30-day-old rat, and after the placing of lateral hypothalamic lesions (57). The slow contractions may outlast the procedure for as long as 2 hr (40).…”

Section: The Role Of Gastric Contractions In the Production Of Gastrimentioning

confidence: 99%

From simplicity to complexity (1950–1990): the case of peptic ulceration—II. Animal studies.

Weiner

1991

Psychosomatic Medicine

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Considerable progress has been made in the understanding of the formation of gastric erosions in rats. The role of gastric acid secretion in their pathogenesis has been clarified. Gastric erosions are also associated with slow gastric contractions. With several experimental procedures, the body temperature falls; preventing this decrease averts erosions. A fall in body temperature or exposure to cold is associated with the secretion of thyrotropin-releasing hormone (TRH), and both an increase and decrease in corticotropin-releasing factor (CRF) in discrete regions of rat brains. TRH produces gastric erosions, increases in acid secretion, and slow contractions, while CRF has the opposite effects. One of the major sites of interaction of the two peptides is in the dorsal motor complex of the vagus nerve. TRH increases serotonin (5-HT) secretion into the stomach. 5-HT counter-regulates acid secretion and slow contractions. Many other peptides stimulate or inhibit gastric acid secretion.

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Stress procedures lowering body temperature augment gastric motility by increasing the sensitivity to acetylcholine in rats.

Cited by 13 publications

References 17 publications

Red Lacrimal Secretion (Chromodacryorrhea) Induced by Cholinergic Drugs in Rats Subjected to the Watertank Technique

Red Lacrimal Secretion (Chromodacryorrhea) Induced by Cholinergic Drugs in Rats Subjected to the Watertank Technique

Effect of psychogenic stress on gastrointestinal function

From simplicity to complexity (1950–1990): the case of peptic ulceration—II. Animal studies.

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