Stress-related biomarkers in dogs administered regional anaesthesia or fentanyl for analgesia during stifle surgery

Romano, Marta; Portela, Diego A.; Breghi, Gloria; Otero, Pablo E.

doi:10.1111/vaa.12275

Cited by 79 publications

(62 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Efforts to unify the criteria for measuring pain have led to the development of different guides used to recognize this condition based on physical and biological alterations such as behavioural changes [1], facial expression [6], physiological parameters, and biochemical mediators [7,8]. However, these have not proven to be effective because just one parameter can not apply to all animal species since this will differ from one species to another, and even among individuals of the same species [4,9].…”

Section: Introductionmentioning

confidence: 99%

Review of different methods used for clinical recognition and assessment of pain in dogs and cats

Hernández-Ávalos

Mota-Rojas

Mora-Medina

et al. 2019

International Journal of Veterinary Science and Medicine

View full text Add to dashboard Cite

In light of the need to perform surgical techniques and the importance of animal welfare because of acute pain, the objectives of the veterinary anaesthetists are to manage muscle relaxation and adequate analgesia in order to conserve a balance in the autonomic nervous system, enhance the action of the parasympathetic system in the face of the emerging action of the sympathetic portion provoked by the surgeon, and maintain a balance among them. The aim of the present review is to describe different evaluation criteria for acute pain using unidimensional and multidimensional scales, correlating these findings to parasympathetic tone activity (PTA) and bispectral index (BIS) assessment, to conduct an objective evaluation of pain that patients (dog or cat) perceives, in order to administrate an adequate analgesic treatment in each case. In conclusion, this integral, objective evaluation will allow veterinariansespecially anaesthesiologiststo improve the management of pain in the patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Review of different methods used for clinical recognition and assessment of pain in dogs and cats

Hernández-Ávalos

Mota-Rojas

Mora-Medina

et al. 2019

International Journal of Veterinary Science and Medicine

View full text Add to dashboard Cite

show abstract

“…Epidural anesthesia has been widely used as an adjuvant anesthetic technique in dogs due to its perioperative analgesia [ 1 ], reduction of general anesthetics requirements [ 2 , 3 ], muscle relaxation, and attenuation of the stress response to surgery [ 4 , 5 ]. Epidural anesthesia has been associated with improved clinical outcome in humans, but this association has not yet been demonstrated in dogs [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular and respiratory effects of lumbosacral epidural bupivacaine in isoflurane-anesthetized dogs: The effects of two volumes of 0.25% solution

et al. 2018

View full text Add to dashboard Cite

The purpose of this study was to compare cardiovascular and respiratory effects of two volumes of bupivacaine 0.25% (0.2 mL kg-1—treatment BUP02—and 0.4 mL kg-1 –treatment BUP04) administered epidurally at the lumbosacral intervertebral space in dogs anesthetized with isoflurane. This experimental prospective randomized crossover design trial used six mixed breed adult dogs, four neutered males and two spayed females. Each dog was anesthetized on three different occasions: the first for isoflurane minimum alveolar concentration (MAC) measurement, and the following two assigned treatments (BUP02 or BUP04). On the two treatment days, anesthesia was induced and maintained with isoflurane at 1.3 MAC during the experiments. Cardiovascular and respiratory measurements were recorded before (T0) and 5, 15, 30, 60 and 90 minutes after the epidural administration of bupivacaine. Comparisons between and within groups were performed by a mixed-model ANOVA and Friedman’s test when appropriate followed by Bonferroni post-hoc test or Dunnet’s test to compare time points within each treatment with T0 (p < 0.05). Mean arterial pressure decreased significantly from 15 to 90 minutes after the administration of BUP02 and from 5 to 60 minutes in BUP04, with lower values in BUP04 than in BUP02 lasting up to 30 minutes after bupivacaine administration. No significant changes in cardiac output and systemic vascular resistance were observed in either treatment. Hypoventilation was only detected in BUP04. Hemoglobin concentration and arterial oxygen content decreased after both treatment of bupivacaine with no significant decrease in oxygen delivery. Two dogs in BUP04 developed Horner’s syndrome. The epidural administration of 0.4 mL.kg-1 of bupivacaine to dogs in sternal recumbency anesthetized with isoflurane 1.3 MAC caused more cardiovascular and respiratory depression than 0.2 mL.kg-1.

show abstract

“…In these cases, minimal maternal and fetal depression (22) and less cardiopulmonary depression than general anesthesia (23) have been observed. Epidural anesthesia has been frequently used in combination with general anesthesia to reduce anesthetic and analgesic requirements, improve analgesia, and quality of anesthetic recovery (8, 24–26). …”

Section: Introductionmentioning

confidence: 99%

An Update on Drugs Used for Lumbosacral Epidural Anesthesia and Analgesia in Dogs

Steagall

2017

Front. Vet. Sci.

View full text Add to dashboard Cite

This review aims to report an update on drugs administered into the epidural space for anesthesia and analgesia in dogs, describing their potential advantages and disadvantages in the clinical setting. Databases searched include Pubmed, Google scholar, and CAB abstracts. Benefits of administering local anesthetics, opioids, and alpha2 agonists into the epidural space include the use of lower doses of general anesthetics (anesthetic “sparing” effect), perioperative analgesia, and reduced side effects associated with systemic administration of drugs. However, the potential for cardiorespiratory compromise, neurotoxicity, and other adverse effects should be considered when using the epidural route of administration. When these variables are considered, the epidural technique is useful as a complementary method of anesthesia for preventive and postoperative analgesia and/or as part of a balanced anesthesia technique.

show abstract

Stress-related biomarkers in dogs administered regional anaesthesia or fentanyl for analgesia during stifle surgery

Cited by 79 publications

References 32 publications

Review of different methods used for clinical recognition and assessment of pain in dogs and cats

Review of different methods used for clinical recognition and assessment of pain in dogs and cats

Cardiovascular and respiratory effects of lumbosacral epidural bupivacaine in isoflurane-anesthetized dogs: The effects of two volumes of 0.25% solution

An Update on Drugs Used for Lumbosacral Epidural Anesthesia and Analgesia in Dogs

Contact Info

Product

Resources

About