Stress-related endocrinological and psychopathological effects of short- and long-term 50Hz electromagnetic field exposure in rats

Szemerszky, Renáta; Zelena, Dóra; Barna, István; Bárdos, György

doi:10.1016/j.brainresbull.2009.10.015

Cited by 75 publications

(74 citation statements)

References 63 publications

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“…Alteration in locomotor activity is in contradiction with findings of some researchers that reported no change in locomotor activity of rats after exposure to ELF/EMF. 24,26 On the other hand, a significant decrease in swim speed of exposed animal to 60 Hz MF tested by water-maze was reported 36 which can be in accordance with our findings. In order to shed light on some aspects of this finding, the unit activities of LC was measured following both 3 Hz and 60 Hz exposures.…”

Section: Discussionsupporting

confidence: 91%

“…25 In addition, high intensity electromagnetic can induce de- pression or metabolic disturbances. 26 It is also suggested that the exposure of 50 Hz ELF-MFs can cause oxidative stress-based nervous system pathologies associated with ageing 27 and increase blood brain barrier permeability. 28 Marchionni et al has reported that 50/60 Hz magnetic field can modify the firing rate of rat sensory neurons.…”

Section: Introductionmentioning

confidence: 99%

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Effects of 3 Hz and 60 Hz Extremely Low Frequency Electromagnetic Fields on Anxiety-Like Behaviors, Memory Retention of Passive Avoidance and Electrophysiological Properties of Male Rats

et al. 2016

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IntroductionThe effects of electromagnetic fields on biological organisms have been a controversial and also interesting debate over the past few decades, because modern civilization is overwhelmed by a broad range of electromagnetic fields, including extremely low frequency electromagnetic fields (ELF/EMF). Numerous investigations, from monitoring changes at molecular levels to the behavioral aspects, have been carried out in vitro and in vivo in order to illustrate different effects of ELF/EMF e.g., its impacts on cells, 1 hormones, 2-6 neurophysiological properties and sleep, 7,8 biochemical factors and metabolism, 9-11 pathology, 12,13 DNA damages and chromosome abnormalities, [14][15][16][17][18][19] reproduction and development, 20 and cancer. [21][22][23] On the other hand, the fact that central nervous system (CNS) as a very complicated electrochemical system may be influenced by electromagnetic fields attracts many researches interests. Vázquez-García et al reported that exposure to 60 Hz ELF/EMF can improves social recognition in male rats. The effects of electromagnetic fields on biological organisms have been a controversial and also interesting debate over the past few decades, despite the wide range of investigations, many aspects of extremely low frequency electromagnetic fields (ELF/EMFs) effects including mechanism of their interaction with live organisms and also their possible biological applications still remain ambiguous. In the present study, we investigated whether the exposures of ELF/EMF with frequencies of 3 Hz and 60 Hz can affect the memory, anxiety like behaviors, electrophysiological properties and brain's proteome in rats. Methods: Male rats were exposed to 3 Hz and 60 Hz ELF/EMFs in a protocol consisting of 2 cycles of 2 h/day exposure for 4 days separated with a 2-day interval. Short term memory and anxiety like behaviors were assessed immediately, 1 and 2 weeks after the exposures. Effects of short term exposure were also assessed using electrophysiological approach immediately after 2 hours exposure. Results: Behavioral test revealed that immediately after the end of exposures, locomotor activity of both 3 Hz and 60 Hz exposed groups significantly decreased compared to sham group. This exposure protocol had no effect on anxiety like behavior during the 2 weeks after the treatment and also on short term memory. A significant reduction in firing rate of locus coeruleus (LC) was found after 2 hours of both 3 Hz and 60 Hz exposures. Proteome analysis also revealed global changes in whole brain proteome after treatment. Conclusion: Here, some evidence regarding the fact that such exposures can alter locomotor activity and neurons firing rate in male rats were presented.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effects of 3 Hz and 60 Hz Extremely Low Frequency Electromagnetic Fields on Anxiety-Like Behaviors, Memory Retention of Passive Avoidance and Electrophysiological Properties of Male Rats

et al. 2016

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“…This explains an increase in body mass of rats in the melatonin treated group. Szemerszky et al (2009) reported a hormonal stress reaction and a depression like behaviour after the long term exposure to microwaves in rats (29). Latest researches show that this effect is mediated by N-methyl D-aspartate (NMDA) receptor complex, which takes a part in the pathogenesis of depression and anxiety.…”

Section: Discussionmentioning

confidence: 99%

The effect of melatonin on body mass and behaviour of rats during an exposure to microwave radiation from mobile phone

Djordjević¹,

Kocić²,

Babović³

et al. 2012

BLL

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Abstract:Background: Microwave radiation (MW) produced by wireless telecommunications and a number of electrical devices used in household or in healthcare institutions may cause various disorders in human organism. On the other hand, melatonin is a potent antioxidant, immunostimulator and neuromodulator. The aim of this research was to determine body mass and behaviour changes in rats after a chronic microwave exposure, as well as to determine the effects of melatonin on body mass and behaviour in irradiated rats. Methods: Wistar rats were divided into the four experimental groups: I group (control) -rats treated with 0,9 % saline, II group (Mel) -rats treated with melatonin (2 mg/kg), III group (MW) -rats exposed to MW radiation (4 h/day), IV group (MW+Mel) -rats, which were both exposed to MW radiation and received melatonin premedication (2 mg/kg). Results: A signifi cant body mass reduction was noted in animals exposed to MW radiation when compared to controls after 20, 40 and 60 days (p<0.001). Furthermore, body weight was signifi cantly increased (p<0.05) in irradiated rats, which received melatonin pretreatment (MW+Mel) in comparison to irradiated group (MW) after 20 days. Microwave radiation exposed animals showed an anxiety related behaviour (agitation, irritability) after 10 days of exposure. After the radiation source removal, changes in behaviour were less noticeable. Melatonin administration to irradiated rats caused a decrease in the stress induced behaviour. Conclusion: Microwave radiation causes body mass decrease and anxiety related behaviour in rats, however melatonin causes a reverse of those effects on both body weight and behaviour of irradiated animals (Fig. 2

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“…The flow of alternating current generates a low level EMF. Several reports have suggested that long-term exposure to ELF-EMF induces elevated levels of plasma corticosterone and depressive-like behaviours in rodents [69,69,71]. Continuous exposure of rodents to ELF-EMF promotes a state of chronic stress and triggers activation of the HPA axis [71].…”

Section: Effects Of Electromagnetic Fieldsmentioning

confidence: 99%

“…Several reports have suggested that long-term exposure to ELF-EMF induces elevated levels of plasma corticosterone and depressive-like behaviours in rodents [69,69,71]. Continuous exposure of rodents to ELF-EMF promotes a state of chronic stress and triggers activation of the HPA axis [71]. Another recent report provided evidence that rats exposed to EMF have significantly higher levels of corticosterone than do control animals [72].…”

Section: Effects Of Electromagnetic Fieldsmentioning

confidence: 99%

Effects of Anthropogenic Events and Viral Persistence on Rodent Reservoirs of Hantavirus Infection: Understanding Host-Pathogen Interactions Facilitates Novel Approaches to Intervention Strategies

Mahmud-Al-Rafat¹,

E-Sobhani²,

Taylor‐Robinson³

2015

AJIDM

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Hantaviruses are primarily rodent-borne pathogens which have received considerable attention recently due to their high mortality rates in humans. In order to find the causes of rapid transmission and emergence of hantavirus-associated diseases anthropogenic changes are a priority. These include deforestation, urbanization, noise pollution, light pollution and electromagnetic fields, all of which have been shown to profoundly affect rodent physiology and immunology. Moreover, anthropogenic events promote human-rodent co-habitation and thereby provide a driver to increase rates of transmission and, by extrapolation, levels of infection in humans. Such environmental disruption acts as a chronic stressor to rodents and causes elevated concentrations of glucocorticoids, which are a major class of immunosuppressive hormone. Glucocorticoids are responsible for altering the immune tolerance of rodents, thereby rendering them susceptible to infection. Glucocorticoids induce regulatory T lymphocytes to reduce inflammatory and antiviral responses and to activate regulatory responses, principally through production of the cytokines interleukin-10 and transforming growth factor-β to support viral persistence. In order to develop a low-cost intervention strategy for hantavirus infection consideration should be given to a systemic approach to therapy. This would both aim to achieve a reduction of anthropogenic stressors and to gain a greater understanding of host-pathogen interactions.

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Stress-related endocrinological and psychopathological effects of short- and long-term 50Hz electromagnetic field exposure in rats

Cited by 75 publications

References 63 publications

Effects of 3 Hz and 60 Hz Extremely Low Frequency Electromagnetic Fields on Anxiety-Like Behaviors, Memory Retention of Passive Avoidance and Electrophysiological Properties of Male Rats

Effects of 3 Hz and 60 Hz Extremely Low Frequency Electromagnetic Fields on Anxiety-Like Behaviors, Memory Retention of Passive Avoidance and Electrophysiological Properties of Male Rats

The effect of melatonin on body mass and behaviour of rats during an exposure to microwave radiation from mobile phone

Effects of Anthropogenic Events and Viral Persistence on Rodent Reservoirs of Hantavirus Infection: Understanding Host-Pathogen Interactions Facilitates Novel Approaches to Intervention Strategies

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