Stress-related impairments in cellular immunity

Glacer, Ronald; Kiecolt-Glacer, Janice K.; Stout, Julie C.; Tarr, Kathleen L.; Speicher, Carl E.; Holliday, Jane

doi:10.1016/0165-1781(85)90111-8

Cited by 228 publications

(65 citation statements)

References 10 publications

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“…Also, there is ample evidence that stress causes impairments in the various aspects of CMI function. For example, spousal caregivers of dementia victims were shown to have a decrement in their cellular immunity [38] , and the natural killer cell activity was reduced when college students were facing examination stress [39] . However, whether CMI is suppressed in PTSD is still controversial, although positive findings were reported in 2 separate papers [5,40] .…”

Section: Discussionmentioning

confidence: 99%

Disturbance of Serum Interleukin-2 and Interleukin-8 Levels in Posttraumatic and Non-Posttraumatic Stress Disorder Earthquake Survivors in Northern China

Song¹,

Zhou²,

Zhang³

et al. 2007

Neuroimmunomodulation

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Objective: It is evident that immune cytokines are involved in the pathophysiology of posttraumatic stress disorder (PTSD), but results of different studies are still inconsistent. Here, serum interleukin (IL)-2, IL-6 and IL-8 levels were compared between earthquake survivors with PTSD, those with non-PTSD and normal controls to investigate whether there is any relationship between cytokine levels and PTSD. In addition, the relationship of these cytokines with psychological parameters of the disorder was examined as well. Methods: Thirty-four earthquake survivors with PTSD (according to DSM-IV criteria), 30 earthquake survivors with non-PTSD and 34 controls were recruited in northern China using the Composite International Diagnostic Interview instrument. Serum IL-2, IL-6 and IL-8 levels were compared. IL-2 levels were measured by radioimmunometric assay, while serum IL-6 and IL-8 levels were measured using sandwich enzyme-linked immunosorbent assay. Psychological symptoms were assessed using 3 subscales of the Symptoms Checklist (SCL-90-R), including depression, anxiety and somatization. Results: Only earthquake survivors diagnosed with PTSD had significantly lower serum IL-8 levels. Also, we found that earthquake survivors (either with PTSD or non-PTSD) had significantly lower serum IL-2 levels and more severe psychological symptoms. The severity of depressive and anxiety symptoms in earthquake survivors was positively related to serum IL-6 levels. Conclusions: PTSD may be associated with a reduced level of serum IL-8, and traumatic survivors may be associated with a lower level of serum IL-2.

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Section: Discussionmentioning

confidence: 99%

Disturbance of Serum Interleukin-2 and Interleukin-8 Levels in Posttraumatic and Non-Posttraumatic Stress Disorder Earthquake Survivors in Northern China

Song¹,

Zhou²,

Zhang³

et al. 2007

Neuroimmunomodulation

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“…The effect of stress on individual health, for example, is thoroughly documented (Barefoot, Dodge, Peterson, Dahlstrom, & Williams, 1989;Friedman & Rosenman, 1974;Glaser, Kiecolt-Glaser, Stout, Tarr, Speicher, & Holiday, 1985;Glaser, Ric-, Speicher, Stout, Kiecolt-Glaser, 1986;Haynes, Feinleib, & Kannel, 1980;Jemmott, Borysenko, McClelland, Chapman, Meyer, & Benson, 1985;Schleifer, Keller, McKegney, & Stein, 1979;Suarez & Williams, 1989).…”

Section: Sintroductionmentioning

confidence: 99%

Associations Between Mood and Specific Health Composites during Navy Persian Gulf Operations

Burr¹,

Woodruff²,

Banta³

1990

PsycEXTRA Dataset

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Background and ObjectivesThe association between mood and health symptoms has received attention from researchers concerned with military performance in extreme conditions, such as the heat and humidity encountered in the Persian Gulf.Previously conducted field studies using shipboard U.S. Navy personnel during at-sea operations in the Persian Gulf have shown that crevmembers experience mood changes such as psychological fatigue, feelings of confusion, tension/ anxiety, and depression and additionally report degradations in general physical health.The objectives of this study were to: a) extend previous research by using specific health complaints rather than a general measure of health and b) examine the relationship between mood and specific health complaints among personnel deployed in the Persian Gulf. ApproachQuestionnaire data were collected from 104 volunteers serving aboard two U.S. Navy ships (AGF and an MSO) deployed in the Persian Gulf. Self-reported mood and health symptoms were provided by subjects as part of a larger questionnaire appraising reactions to sustained operations under high heat and humid conditions. Mood was a9sessed using the Profile of Mood States Tension/Anxiety and Fatigue scales.Health symptoms were measured using the Environmental Symptom3 Questionnaire (ESQ), a 52-item inventory designed to sample subjective reactions and health symptomatology during exposure to extreme environments.The ESO items were organized into 11 specific composites, and multiple regression procedures were used to determine the independent contributicn of the two mood scales to the 11 specific health composites.

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“…1989], Nehmen wir den Befund, daß Hypercortisolismus bei Depression ein gut gesicherter Befund ist [Nemeroff, 1991], der als Statemarker für chronisches streßbezogenes Hyper arousal angesehen werden kann [Chrousos und Gold. 1992 [Glaser et al, 1985: Irwin et al. 1987: Schleifer et al.…”

Section: Der Einfluß Psychotherapeutischer Verfahren Auf Die Mediziniunclassified

Krebs und Depression

Spiegel¹

1994

Verhaltenstherapie

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Die Prävalenz von depressiven Erkrankungen ist bei Anlegen konservativer Kriterien bei stationär behandelten organmedizinischen Patienten dreifach und bei ambulant behandelten Patienten zweifach erhöht. Fast 50% aller Krebspatienten erfüllen die Kriterien einer psychischen Störung. Dabei sind Anpassungsstörungen mit depressiver Stimmungslage die häufigste Komplikation. Angsterkrankungen scheinen darüber hinaus zu einer Verzögerung in der Früherkennung und Differentialdiagnostik von Krebserkrankungen zu führen, die die Krebsüberlebenszeit um 10–20% reduziert.Depressive Erkrankungen werden häufig bei körperlich Kranken nicht diagnostiziert, da 1. der Fokus der ärztlichen Intervention auf den körperlichen Zeichen und Symptomen liegt, 2. depressive Symptome wie Energieverlust, Appetitstörung und Schlafstörung häufig fehlerhaft auf die Krebserkrankung und die Behandlungskomplikation zurückgeführt werden, 3. noch vielfach ein therapeutischer Nihilismus gegenüber der Beeinfluβbarkeit psychischer Störungen vorherrscht. Neuere Studien haben in diesem Zusammenhang nicht bestätigen können, daβ Personen mit einer depressiven Erkrankung ein höheres Krebsinzidenzrisiko haben als Personen ohne eine Depression. Jedoch konnte vielfach gezeigt werden, daβ effektive psychotherapeutische Behandlungsmaβnahmen gegen die Depression auch den Verlauf von Krebserkrankung positiv beeinflussen können. Psychotherapie für körperlich kranke Patienten reduziert die Angst, Depression und den Schmerzintensitätspegel. Zusätzlich konnte bezüglich der Psychotherapie bei Krebserkrankung ein überraschend deutlicher Effekt auf die Krankheitsprogression objektiviert werden. In drei randomisierten Studien konnten signifikant längere Überlebenszeiten für Patienten mit Brustkrebs (18 Monate), Lymphome und maligne Melanome bestätigt werden. Die physiologischen Mechanismen für diese Befunde sind derzeit noch nicht eindeutig geklärt. Diskutiert werden vier fundamentale Einfluβfaktoren: 1. das Gesundheitsverhalten; 2. Verbesserung der Inanspruchnahme; 3. Veränderungen der endokrinen Lage; 4. Veränderungen der Immunfunktion.Effektive Behandlungsprogramme gegen die Depression bei Krebspatienten können zusammenfassend den Verlauf der Krankheit wie auch die Lebensqualität verbessern. Die spezifische Beachtung depressiver Symptome bei Krebspatienten verbessert die Anpassung der Patienten, reduziert die Symptome, führt zu einer Verringerung der Betreuungskosten und verbessert den Krankheitsverlauf.

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Stress-related impairments in cellular immunity

Cited by 228 publications

References 10 publications

Disturbance of Serum Interleukin-2 and Interleukin-8 Levels in Posttraumatic and Non-Posttraumatic Stress Disorder Earthquake Survivors in Northern China

Disturbance of Serum Interleukin-2 and Interleukin-8 Levels in Posttraumatic and Non-Posttraumatic Stress Disorder Earthquake Survivors in Northern China

Associations Between Mood and Specific Health Composites during Navy Persian Gulf Operations

Krebs und Depression

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