Stress relaxation behaviour of trabecular bone specimens

Deligianni, Despina; Maris, A.; Missirlis, Yannis F.

doi:10.1016/0021-9290(94)90196-1

Cited by 46 publications

(37 citation statements)

References 19 publications

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“…Thus, our non-destructive method produced direct evaluations of the impact of processing on trabecular bone. As previously reported (Deligianni et al 1994;Njeh et al 1997), we found differences between the plane aligned with mechanical loads during life and the two other planes. These results indicating anisotropic behaviour of the bone specimens validate the collection, preservation, and preparation procedures used in our study.…”

Section: Discussionsupporting

confidence: 78%

Effects of gamma irradiation on mechanical properties of defatted trabecular bone allografts assessed by speed-of-sound measurement

Vastel

Massé

Crozier

et al. 2007

Cell Tissue Banking

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New sterilization methods for human bone allografts may lead to alterations in bone mechanical properties, which strongly influence short- and medium-term outcomes. In many sterilization procedures, bone allografts are subjected to gamma irradiation, usually with 25 KGy, after treatment and packaging. We used speed-of-sound (SOS) measurements to evaluate the effects of gamma irradiation on bone. All bone specimens were subjected to the same microbial inactivation procedure. They were then separated into three groups, of which one was treated and not irradiated and two were exposed to 10 and 25 KGy of gamma radiation, respectively. SOS was measured using high- and low-frequency ultrasound beams in each orthogonal direction. SOS and Young modulus were altered significantly in the three groups, compared to native untreated bone. Exposure to 10 or 25 KGy had no noticeable effect on the study variables. The impact of irradiation was small compared to the effects of physical or chemical defatting. Reducing the radiation dose used in everyday practice failed to improve graft mechanical properties in this study.

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Section: Discussionsupporting

confidence: 78%

Effects of gamma irradiation on mechanical properties of defatted trabecular bone allografts assessed by speed-of-sound measurement

Vastel

Massé

Crozier

et al. 2007

Cell Tissue Banking

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“…Finally, it is reasonable to believe that CAB might increase with increasing strain rate due to viscoelastic effects. 15 The dependence of CAB in the S-I direction on bone density may seem surprising because strain to failure generally has not been well correlated with den~i t y .~J -' * This result can be explained by the fact that elastic modulus and postfailure slope were used to compute and both of these measures were correlated with density. Thus as density increases modulus increases and postfailure slope becomes more negative, both of which tend to increase CAB.…”

Section: Discussionmentioning

confidence: 94%

Postfailure compressive behavior of tibial trabecular bone in three anatomic directions

Keyak

Lee

Nath

et al. 1996

J. Biomed. Mater. Res.

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To obtain information describing the postfailure behavior of human proximal tibial trabecular bone, cube specimens of bone were mechanically tested in compression beyond the point of failure. Tests were performed in the three anatomic directions, plots of stress versus strain were obtained, and measures to describe the stress-strain relations before, during, and after failure were defined. These measures included elastic modulus, strength, postfailure slope, strain during maximum stress, and first postfailure minimum stress. For each anatomic direction, analyses were performed to correlate these parameters with ash density. Each of these measures was significantly correlated with ash density at the p < 0.05 level for all test directions, except for postfailure slope, which was correlated in the mediolateral and superior-inferior directions, and strain during maximum stress, which was correlated only in the superior-inferior direction. The data from this study enable trilinear stress-strain relations to be estimated for proximal tibial trabecular bone of various densities, and can serve as a first step toward modeling the behavior of trabecular bone before, during, and after failure.

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“…Although the general model they proposed had the capability to include greater complexity, they applied the model using an assumption of isotropic damage and time independent plastic flow. Based on evidence from our own studies [116] and others that time-dependence [117] and damage anisotropy are significant in trabecular bone and a lack of specific experimental basis for assuming an intrinsic link between plastic flow and damage, we developed a unified constitutive model to describe the elastic and inelastic (viscoelastic, plastic, and damage) behavior of human vertebral trabecular bone [116]. Material parameters were defined in terms of measures of trabecular density and architecture.…”

Section: Continuum Damage Mechanics Modeling Of Bonementioning

confidence: 99%

Computational Analysis of Bone Fracture

Nicolella

Bredbenner

2014

Accidental Injury

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Age-related non-traumatic fractures are a major public health problem with fracture of the proximal femur resulting in significant patient mortality. Currently, the clinical gold standard for assessing an individual's fracture risk is dual-energy x-ray absorptiometry (DEXA). Although DXA-based bone mineral density (BMD) measurements have been shown to correlate with fracture risk, BMD distributions describing normal individuals and those who have suffered a hip fracture contain significant overlap, thereby reducing the specificity of BMD based fracture risk categorization. Since bone strength results from a combination of bone mass, bone micro-architecture and material properties, and overall bone geometry, two-dimensional imaging based diagnostic approaches such as DEXA are limited in their ability to specifically predict bone strength. Engineering models of skeletal structures that combine descriptions of three dimensional bone geometry, bone mass distribution, and bone material behavior into a high fidelity simulation have been shown to predict bone strength with an improved accuracy compared to DEXA alone, albeit with some limitations. Specifically, voxel based finite element models derived from QCT image data are based on correlations between predicted structural stiffness and structural failure and therefore are generally only valid for simple uniaxial loading; it is unlikely this approach would be valid for more complex applied loads. Furthermore, these models generally use simplified bone material descriptions that do not capture the demonstrated non-linear damaging behavior of bone and do not model bone material

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Stress relaxation behaviour of trabecular bone specimens

Cited by 46 publications

References 19 publications

Effects of gamma irradiation on mechanical properties of defatted trabecular bone allografts assessed by speed-of-sound measurement

Effects of gamma irradiation on mechanical properties of defatted trabecular bone allografts assessed by speed-of-sound measurement

Postfailure compressive behavior of tibial trabecular bone in three anatomic directions

Computational Analysis of Bone Fracture

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