Stress response asymmetries in African American emerging adults exposed to chronic social adversity

Wood, Erin E.; Criss, Michael M.; Byrd‐Craven, Jennifer

doi:10.1080/10253890.2021.1955852

Cited by 4 publications

(6 citation statements)

References 33 publications

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“…Dysregulated levels of these hormones have been found in individuals experiencing low SES, depression, abuse-related posttraumatic stress disorder, discrimination, neighborhood deprivation, air pollution, or limited greenspace. 51,[115][116][117][118] This chronic activation of the SNS by way of the hypothalamic-pituitary-adrenal and sympatho-adrenomedullary axes has been linked to altered stress hormone signaling that results in increased inflammation. 119 Glucocorticoid receptor resistance results from chronic activation of the SNS and the hypothalamic-pituitary-adrenal axis 120 and has been linked to blunting of the anti-inflammatory response, allowing for the development and progression of CVD.…”

Section: Social Determinants Of Health and Inflammation: Stress Hormonesmentioning

confidence: 99%

Section: Social Determinants Of Health and The Biology Of Adversitymentioning

confidence: 99%

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Social Determinants of Cardiovascular Disease

Powell‐Wiley

Baumer

Baah

et al. 2022

Circulation Research

392

213

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Social determinants of health (SDoH), which encompass the economic, social, environmental, and psychosocial factors that influence health, play a significant role in the development of cardiovascular disease (CVD) risk factors as well as CVD morbidity and mortality. The COVID-19 pandemic and the current social justice movement sparked by the death of George Floyd have laid bare long-existing health inequities in our society driven by SDoH. Despite a recent focus on these structural drivers of health disparities, the impact of SDoH on cardiovascular health and CVD outcomes remains understudied and incompletely understood. To further investigate the mechanisms connecting SDoH and CVD, and ultimately design targeted and effective interventions, it is important to foster interdisciplinary efforts that incorporate translational, epidemiological, and clinical research in examining SDoH-CVD relationships. This review aims to facilitate research coordination and intervention development by providing an evidence-based framework for SDoH rooted in the lived experiences of marginalized populations. Our framework highlights critical structural/socioeconomic, environmental, and psychosocial factors most strongly associated with CVD and explores several of the underlying biologic mechanisms connecting SDoH to CVD pathogenesis, including excess stress hormones, inflammation, immune cell function, and cellular aging. We present landmark studies and recent findings about SDoH in our framework, with careful consideration of the constructs and measures utilized. Finally, we provide a roadmap for future SDoH research focused on individual, clinical, and policy approaches directed towards developing multilevel community-engaged interventions to promote cardiovascular health.

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Section: Social Determinants Of Health and Inflammation: Stress Hormonesmentioning

confidence: 99%

Section: Social Determinants Of Health and The Biology Of Adversitymentioning

confidence: 99%

Social Determinants of Cardiovascular Disease

Powell‐Wiley

Baumer

Baah

et al. 2022

Circulation Research

392

213

View full text Add to dashboard Cite

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“…Eleven of the 19 were secondary data analyses (Aiyer et al, 2014; Assari et al, 2015; Barber et al, 2016; Estrada-Martinez et al, 2012; Gebreab et al, 2017; Heinze et al, 2018; Hsieh et al, 2017, 2022; Kapur et al, 2022; Pahl et al, 2020; Russell et al, 2016). Seven of the 19 studies were cross-sectional or correlational designs (Banerjee et al, 2015; Bowleg et al, 2014; Hotton et al, 2019; Janusek et al, 2017; Quinn et al, 2016; Smith et al 2020; Wood et al, 2021). None of the studies were randomized control trials.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies examined the hormonal changes that occur from CVE (Aiyer et al, 2014; Janusek et al, 2017; Wood et al, 2021). Aiyer and Colleagues (2014) found that cumulative exposure to violence was correlated to an attenuated cortisol response in Black emerging adult men ( p < .01), but the relationship was not significant for Black emerging adult women.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies were considered “A” or high quality after review of criteria according to JHNEBP (Banerjee et al, 2015; Barber et al, 2016; Gebreab et al, 2017; Heinze et al, 2018; Hotton et al, 2019; Hsieh et al, 2022; Kapur et al, 2022; Pahl et al, 2020). Two studies were considered low quality due to small sample size (Janusek et al, 2017; Wood et al, 2021). The remaining nine studies were given a “B” or good quality rating.…”

Section: Methodsmentioning

confidence: 99%

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Physical and Mental Health Outcomes of Black Emerging Adults with Community Violence Exposure: An Integrative Review

Walker,

Bills,

Motley

2023

Trauma, Violence, & Abuse

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Community violence exposure (CVE) and its health impact is a public health crisis. Violent crime has steadily increased over recent years and has disproportionately affected Black communities. Emerging adulthood (18–29 years old) is a vulnerable period of development and Black emerging adults may be at increased risk for negative physical and mental health consequences from CVE. This integrative review was conducted to evaluate available evidence on health outcomes in Black emerging adults exposed to CVE. This review appraised published studies (2012–2022) addressing physical and mental health outcomes of Black emerging adults with CVE. Articles were identified using structured search terms in several databases (CINAHL, PubMed, PsycInfo, and Web of Science), a gray literature search, and citation mining. A total of 177 studies were identified for screening and 19 studies met inclusion criteria and were included in the review. The majority of studies found a significant positive association between CVE and adverse mental ( n = 12) and physical ( n = 7) health outcomes. CVE appears to have both mental and physical health consequences for Black emerging adults. Given that violent crime disproportionately increased in Black communities and Black people are more likely to develop chronic health conditions at younger ages, more work is needed to elucidate the relationship between CVE and health outcomes.

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