Stress Response Regulation in Panic Disorder

Ising, Marcus; Höhne, Nina; Siebertz, Anna; Parchmann, Anna-Mareike; Erhardt, Angelika; Keck, Martin E.

doi:10.2174/138161212803530880

Cited by 18 publications

(17 citation statements)

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“…Our finding of increased A 1 AR availability in risk allele carriers is in line with these findings and suggestions. Stress response regulation including HPA axis activation is altered in panic disorder patients (recent review by Ising et al, 2012) and sleep deprivation occurs with negative mood and increased anxiety up to catastrophizing in them (Kahn et al, 2013). Notably, these consequences of sleep deprivation are greater after the presentation of a mild stressor, possibly due to a lowered psychological threshold to estimate a situation as stressful (Minkel et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Association of Adenosine Receptor Gene Polymorphisms and In Vivo Adenosine A1 Receptor Binding in The Human Brain

Hohoff¹,

Garibotto²,

Elmenhorst³

et al. 2014

Neuropsychopharmacol

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Adenosine A1 receptors (A1ARs) and the interacting adenosine A2A receptors are implicated in neurological and psychiatric disorders. Variants within the corresponding genes ADORA1 and ADORA2A were shown associated with pathophysiologic alterations, particularly increased anxiety. It is unknown so far, if these variants might modulate the A1AR distribution and availability in different brain regions. In this pilot study, the influence of ADORA1 and ADORA2A variants on in vivo A1AR binding was assessed with the A1AR-selective positron emission tomography (PET) radioligand [(18)F]CPFPX in brains of healthy humans. Twenty-eight normal control subjects underwent PET procedures to calculate the binding potential BPND of [(18)F]CPFPX in cerebral regions and to assess ADORA1 and ADORA2A single nucleotide polymorphism (SNP) effects on regional BPND data. Our results revealed SNPs of both genes associated with [(18)F]CPFPX binding to the A1AR. The strongest effects that withstood even Bonferroni correction of multiple SNP testing were found in non-smoking subjects (N=22) for ADORA2A SNPs rs2236624 and rs5751876 (corr. Pall<0.05). SNP alleles previously identified at risk for increased anxiety like the rs5751876 T-allele corresponded to consistently higher A1AR availability in all brain regions. Our data indicate for the first time that variation of A1AR availability was associated with ADORA SNPs. The finding of increased A1AR availability in regions of the fear network, particularly in ADORA2A risk allele carriers, strongly warrants evaluation and replication in further studies including individuals with increased anxiety.

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Section: Discussionmentioning

confidence: 99%

Association of Adenosine Receptor Gene Polymorphisms and In Vivo Adenosine A1 Receptor Binding in The Human Brain

Hohoff¹,

Garibotto²,

Elmenhorst³

et al. 2014

Neuropsychopharmacol

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“…However, PD patients exhibit an increased coupling of feedback-evoked EEG amplitude and heart rate changes than healthy individuals ( Mueller et al, 2014 ), which has previously been shown to be an indicator of neuro-visceral connectivity ( Mueller et al, 2010a ). Regarding the physiological stress axes, PD patients do not differ from healthy individuals in baseline morning or diurnal cortisol release or negative feedback sensitivity ( Ising et al, 2012 ), but they show blunted cortisol responses to psychosocial stress ( Petrowski et al, 2010 , 2013 ). In terms of SAM axis activity existing studies have yielded mixed findings.…”

Section: Synthesis Of Findings On Interoception and Stressmentioning

confidence: 99%

Interoception and stress

2015

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Afferent neural signals are continuously transmitted from visceral organs to the brain. Interoception refers to the processing of visceral-afferent neural signals by the central nervous system, which can finally result in the conscious perception of bodily processes. Interoception can, therefore, be described as a prominent example of information processing on the ascending branch of the brain–body axis. Stress responses involve a complex neuro-behavioral cascade, which is elicited when the organism is confronted with a potentially harmful stimulus. As this stress cascade comprises a range of neural and endocrine pathways, stress can be conceptualized as a communication process on the descending branch of the brain–body axis. Interoception and stress are, therefore, associated via the bi-directional transmission of information on the brain–body axis. It could be argued that excessive and/or enduring activation (e.g., by acute or chronic stress) of neural circuits, which are responsible for successful communication on the brain–body axis, induces malfunction and dysregulation of these information processes. As a consequence, interoceptive signal processing may be altered, resulting in physical symptoms contributing to the development and/or maintenance of body-related mental disorders, which are associated with stress. In the current paper, we summarize findings on psychobiological processes underlying acute and chronic stress and their interaction with interoception. While focusing on the role of the physiological stress axes (hypothalamic-pituitary-adrenocortical axis and autonomic nervous system), psychological factors in acute and chronic stress are also discussed. We propose a positive feedback model involving stress (in particular early life or chronic stress, as well as major adverse events), the dysregulation of physiological stress axes, altered perception of bodily sensations, and the generation of physical symptoms, which may in turn facilitate stress.

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“…PD is a common psychiatric disorder with a complex etiology that likely involves multiple genes in addition to nongenetic influences. 22 , 23 , 24 , 25 , 26 , 27 Many previous studies have identified associations between BDNF polymorphisms and psychiatric disorders. Associations have been found between the BDNF 196G/A (rs6265) polymorphism and chronic depression, 28 treatment response in patients with major depression, 29 and Alzheimer's disease, 30 , 31 although findings have not always been consistent.…”

Section: Discussionmentioning

confidence: 99%

Evidence for Association between the Brain-Derived Neurotrophic Factor Gene and Panic Disorder: A Novel Haplotype Analysis

Han

Kim

Hwang

et al. 2015

Psychiatry Investig

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ObjectivePanic disorder (PD) is a common psychiatric disorder with a complex etiology, and several studies have suggested that it has a genetic component. Brain-derived neurotrophic factor (BDNF) is the most abundant of the neurotrophins in the brain and is recognized for its important role in the survival, differentiation and growth of neurons. Several lines of research have suggested possible associations between the BDNF gene and PD. In this study, we investigated the BDNF 196G/A (rs6265), 11757G/C (rs16917204), and 270C/T (rs56164415) single nucleotide polymorphisms (SNPs) in order to determine an association with PD. We also identified the genetic sequence associations with PD via haplotype analysis.MethodsParticipants in this study included 136 PD patients and 263 healthy controls. Male and female subjects were analyzed separately. The genotype and allele frequencies of the PD patients and controls were analyzed using χ2 statistics. Frequencies and haplotype reconstructions were calculated using the SNP analyzer 2.0.ResultsWe found no significant statistical differences in the genotype distributions or allele frequencies of the three tested polymorphisms between the PD and control groups. In addition, no differences were found between PD patients and the controls in either male or female subgroups. However, we found that, the frequency of the G-C haplotype for 196G/A and 11757G/C was significantly higher in PD patients than in the controls.ConclusionOur result suggest that patients with the G-C haplotype for 196G/A and 11757G/C may be more susceptible to the development of PD. Further studies are needed to replicate the associations that we observed.

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Stress Response Regulation in Panic Disorder

Cited by 18 publications

References 0 publications

Association of Adenosine Receptor Gene Polymorphisms and In Vivo Adenosine A1 Receptor Binding in The Human Brain

Association of Adenosine Receptor Gene Polymorphisms and In Vivo Adenosine A1 Receptor Binding in The Human Brain

Interoception and stress

Evidence for Association between the Brain-Derived Neurotrophic Factor Gene and Panic Disorder: A Novel Haplotype Analysis

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