This study focuses on slope stability and geological hazard analyses at the Italian Paleolithic site of Grotta Paglicci. The site is characterized by a cave that contains rich archaeological and anthropological finds, spanning various Paleolithic periods, and includes faunal remains, lithic artifacts, human burials, ornaments, mobiliary art objects, and unique Paleolithic wall paintings. The study employs a multi-technique approach that includes topographic surveys carried out by the robotic total station and GNSS receivers, photogrammetric acquisitions with an unmanned aerial system, 3D SLAM-based LiDAR mapping, and an engineering geological survey. The collected data allowed for the creation of georeferenced 3D models that were utilized in rock slope stability analysis and modeling. The results of this comprehensive survey highlighted how the bedding and joint discontinuities influence rock stability in both the external and internal areas of the cave. The integrated use of SLAM-based LiDAR and photogrammetry has been proven to be an efficient and essential tool in the evaluation of the structural interactions between the external morphology and the cave, thus allowing the proposal of safety measures that will keep the site accessible for future activities.