Stress‐Triggered Abortion in Mice Prevented by Alloimmunization

Clark, David A.; Banwatt, Daljeet; Chaouat, Gérard

doi:10.1111/j.1600-0897.1993.tb00579.x

Cited by 86 publications

(65 citation statements)

References 35 publications

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“…Meanwhile, control mice remain in a room undisturbed by sound. Sonic stress has been used in various animal models as an effective inductor of stress reactions [67][68][69] . It is based on pilot experiments employing stress challenge ranging from 45 min, 2, 4, 12, 24, and 48 h of sound, which led to appreciate 24 h of sound challenge as a moderate stressor.…”

Section: Model Of Stress and Asthmamentioning

confidence: 99%

Stress and Airway Reactivity in a Murine Model of Allergic Airway Inflammation

Quarcoo

Pavlović²,

Joachim³

2009

Neuroimmunomodulation

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Airway reactivity is a phenomenon with vast clinical implications in children. The regulation of airway reactivity is influenced by local and central mechanisms. In airway diseases like bronchial asthma, the pathological regulation of the airway caliber causes symptoms like cough and dyspnea. Stress has long been considered a powerful manipulator in the physiological regulation of the airways. To explore potential mechanisms linking stress to the exacerbation of asthma, we developed an animal model that combines allergic airway inflammation and exposure to stress. This review summarizes the experimental data obtained in our and similar mouse models. First, we describe the innervation and neuromediators in the airways, next we analyze the occurrence of airway hyperresponsiveness, and then we explore the phenomenon of stress to finally connect all of the topics in a synopsis.

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Section: Model Of Stress and Asthmamentioning

confidence: 99%

Stress and Airway Reactivity in a Murine Model of Allergic Airway Inflammation

Quarcoo

Pavlović²,

Joachim³

2009

Neuroimmunomodulation

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“…Interestingly, in murine models there is a genetic determinant in response to stress that causes infertility in A/J strain mice, and abortions in C3H strain mice. 17 These findings suggest that women with reproductive failure might have some specific characteristics that have escaped evaluation to date. Future studies should assess whether women with reproductive failure are more responsive to stressful stimuli, and whether these responses predict pregnancy outcome.…”

Section: Discussionmentioning

confidence: 96%

Acute Stress Response in Women with Recurrent Miscarriage and Infertility

Bhandari

2018

Nep. Med. J.

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Introduction: Stress has been linked to reproductive failure which includes miscarriage and Infertility. Several studies showed high levels of psychological stress and stress biomarkers in women with reproductive failure. However, very few studies are done to measure the stress response. So the current study sought to assess whether women with reproductive failure have exaggerated acute stress response. Materials and Methods:This was a cross-sectional comparative study. Blood samples were collected immediately after venipuncture, and again 20 min later from 15 fertile controls, 20 recurrent miscarriage patients, and 40 infertile patients to measure natural killer cells and cortisol levels. Results:The percentage of peripheral blood NK cells (total CD3-CD56+) and serum total cortisol level did not change significantly across the two samples of immediately after venipuncture, and again 20 min later in the fertile controls (p=0.358,and p=0.890 respectively). However, there was a significant decline in the second sample in women with Infertility (p<0.05 for serum cortisol and p<0.05 for NK cell) and with recurrent miscarriage (p<0.05 for serum cortisol). There was a decline of NK cell in the 2 nd sample in women with recurrent miscarriage though not to significant level (P>0.05). Conclusions:Women with recurrent miscarriage and Infertility may be more vulnerable to acute stressor.

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“…Over the past decade, such insights have been advanced by endeavors in basic research aiming to identify pathways of stress-triggered pregnancy complications by employing a mouse model [148][149][150]. To date, it is widely accepted that psychological stress causes an activation of the hypothalamus-pituitary-adrenal (HPA) axis.…”

Section: Psychoneuroimmunology and Reproductionmentioning

confidence: 99%

Reproductive Immunology – an Update

Poehlmann

Fitzgerald

Busch

et al. 2006

Transfus Med Hemother

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Pregnancy is one of the most challenging experiences for the immune system. It entails the confrontation and cooperation of maternal cells with allogeneic (sperm) and semi-allogeneic (fetal) cells and factors. On the one hand, it must actively acquire a specific tolerance towards the foreign cells and organism (the fetus) to avoid harming reactions, while recognizing the very same to support and control their development and growth. On the other hand, the immune system simultaneously may not reduce its capability to defend mother and fetus from microorganisms and pathogens. Almost all branches of the immune system are claimed to react and adapt in order to fulfill these complex duties. In this review, current knowledge concerning the most important cellular and soluble immunological components in the decidua is presented. Special regards are made to decidual NK, T and dendritic cells as well as to trophoblast cells, representing the fetal counterpart of most bilateral interactions. Furthermore, the role and functions of soluble factors, including HLA-G, PIBF, IDO and a variety of cytokines, are described.

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Stress‐Triggered Abortion in Mice Prevented by Alloimmunization

Abstract: Immunotherapy may protect against a variety of potential triggers of spontaneous abortion, including those that may be amenable to psychological remedies, and possible mechanisms are discussed.

Cited by 86 publications

References 35 publications

Stress and Airway Reactivity in a Murine Model of Allergic Airway Inflammation

Stress and Airway Reactivity in a Murine Model of Allergic Airway Inflammation

Acute Stress Response in Women with Recurrent Miscarriage and Infertility

Reproductive Immunology – an Update

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