Stress triggered abortions are associated with alterations of granulated cells in the decidua

Markert, Udo R.; Arck, Petra C.; McKay, Brian; Manuel, José; Chaouat, Gérard; Marshall, J.; Croy, B A; Clark, David W.

doi:10.1016/s0143-4004(96)90265-9

Cited by 8 publications

(15 citation statements)

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“…30,31 Macrophages 32 and mast cells are present, and the latter may be stimulated after stress by SP. 22 We did not observe a significant increase in activation of mast cells by stress nor an effect of blocking the SP-specific NK1 receptor, which would give the link to the influence of SP. This might be due to the interval of 7 days between stress application and examination.…”

Section: Discussioncontrasting

confidence: 54%

“…We examined the effects of stress and application of the SP-RA on the degranulation state of mast cells, as they have been reported to become increasingly degranulated as a sign of activation after stress. 22 As shown in Fig. 2, we observed a slight increase of total and degranulated mast cells per visual field between stressed and non-stressed mice; however, this result did not reach significance level.…”

Section: Resultsmentioning

confidence: 58%

“…This might be due to the interval of 7 days between stress application and examination. Markert et al 22 showed that on day 7.5 (2 days after stress) and day 10.5 (5 days after stress) the percentage of degranulated mast cells was increased, but not on day 12.5 (7 days after stress).…”

Section: Discussionmentioning

confidence: 99%

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Murine Stress‐triggered Abortion is Mediated by Increase of CD8⁺ TNF‐α⁺ Decidual Cells via Substance P

Joachim

Hildebrandt

Oder

et al. 2001

American J Rep Immunol

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Section: Discussioncontrasting

confidence: 54%

Section: Resultsmentioning

confidence: 58%

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Murine Stress‐triggered Abortion is Mediated by Increase of CD8⁺ TNF‐α⁺ Decidual Cells via Substance P

Joachim

Hildebrandt

Oder

et al. 2001

American J Rep Immunol

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“…It has been suggested that TGF-β production by suppressor cells at the fetomaternal interface serves to protect the concepts from an immunological attack by maternal effector cells [19]. Studies showed [17,29] that pregnancy disorders are clearly accompanied by an obvious decrease of TGF-β2 expression at the fetomaternal interface. In the present work, we have observed that diabetic mice that demonstrate a high level of pregnancy failure as well as a significantly increased rate of severely malformed fetuses also exhibit a decreased expression of TGF-β2 in the uterus.…”

Section: Discussionmentioning

confidence: 99%

Diabetes teratogenicity in mice is accompanied with distorted expression of TGF‐β2 in the uterus

Fein

Magid

Savion

et al. 2001

Teratog Carcinog Mutagen

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Early embryonic deaths as well as malformed newborns are among complications of the diabetic pregnancy. Cytokines and growth factors operating in the embryonic vicinity are found to be among factors that determine the sensitivity of embryos to external and internal detrimental stimuli, including diabetes. Transforming Growth Factor-β2 (TGF-β2) has been shown to be essential for embryonic development and survival. In the present work, we evaluated the pattern of TGF-β2 expression in the uterus of streptozotocin-induced diabetic mice, demonstrating a decreased reproductive performance and elevated percentage of litters with severely malformed fetuses. Since stimulation of the maternal immune system was found to increase the resistance of mouse embryos to the teratogenic effect of diabetes, the effect of immunopotentiation on the expression of the cytokine was also investigated. TGF-β2 expression was studied at the mRNA level by using the in situ hybridization technique and at the protein level by using the immunohistochemical analysis. A clear decrease in TGF-β2 mRNA expression in the uterus of diabetic mice was observed at examined time points: days 1, 5, and 9 of pregnancy. Also, an evident reduction in TGF-β2, the protein expression in the uterus of diabetic mice, was demonstrated at these time points. Maternal immunopotentiation that improved the reproductive performance of diabetic mice and reduced the number of the litters with malformed fetuses was also accompanied by a clear increase in the level of TGF-β2 mRNA expression in the pregnant uteri. The above results clearly demonstrate that the embryotoxic effect of diabetes is accompanied by an alteration of TGF-β2 ex- pression. Immunopotentiation that was shown to improve the reproductive performance of the diabetic mice was accompanied by a partial normalization of TGF-β2 expression in embryonic vicinity. Teratogenesis Carcinog. Mutagen. 22:59-71, 2002.

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“…There have been several studies of the vasodilator effect of tachykinins on uterine blood flow [84][85][86] and, as mentioned earlier, on the possible involvement of SP in neuro-immune interactions within uterine tissues. 18,20,87,88 However, our focus in the present review is on tachykinin effects on uterine smooth muscle.…”

Section: Actions Of Tachykinins On Myometrial Contractilitymentioning

confidence: 99%

Effects Of Tachykinins On Uterine Smooth Muscle

Patak

Story

2000

Clin Exp Pharma Physio

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1. Sensory nerves supplying the mammalian uterus have been shown to contain substance P (SP) and neurokinin (NK)A. This review presents some of the advances that have led to a greater understanding of the effects of tachykinins on uterine smooth muscle. 2. The cell-surface peptidase neprilysin (EC.3 24.11, endopeptidase 24.11, enkephalinase, CALLA, CD10) has been shown to play a major role in regulating the actions of tachykinins on both rat and human myometrium. Because this peptidase is known to be regulated by steroids and pregnancy, its effects may be of physiological relevance. 3. Tachykinins produce contractions of isolated myometrial preparations from non-pregnant rats and mice. The NK2 receptor mediates these effects in rat uterus, while the NK1 receptor may mediate these effects in the mouse uterus. 4. The effects of tachykinins have been examined on myometrial preparations obtained at Caesarean section from near-term pregnant women. In the presence of the peptidase inhibitors (thiorphan, captopril and bestatin), the mammalian tachykinins SP, NKA and NKB produced concentration-dependent uterine contractions. 5. The order of agonist potency NKA > SP = NKB suggested that NK2 receptors mediate uterine contractions in the human. This was confirmed using the stable analogues [Sar9,Met(O2)11]SP, [Lys5MeLeu9Nle10]NKA(4-10) and [N-MePhe7]NKB, which are NK1, NK2 and NK3 receptor selective, respectively. Only [Lys5MeLeu9Nle10]NKA(4-10) produced concentration-related contractions of human uterine smooth muscle. 6. The experimental findings described in the present review, taken together with results published previously in the literature, indicate that tachykinin peptides may play a physiological or pathophysiological role in regulating uterine smooth muscle activity. However, more extensive research will be required to confirm such a role for these peptides.

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Stress triggered abortions are associated with alterations of granulated cells in the decidua

Cited by 8 publications

References 0 publications

Murine Stress‐triggered Abortion is Mediated by Increase of CD8⁺ TNF‐α⁺ Decidual Cells via Substance P

Murine Stress‐triggered Abortion is Mediated by Increase of CD8⁺ TNF‐α⁺ Decidual Cells via Substance P

Diabetes teratogenicity in mice is accompanied with distorted expression of TGF‐β2 in the uterus

Effects Of Tachykinins On Uterine Smooth Muscle

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Stress triggered abortions are associated with alterations of granulated cells in the decidua

Cited by 8 publications

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Murine Stress‐triggered Abortion is Mediated by Increase of CD8+ TNF‐α+ Decidual Cells via Substance P

Murine Stress‐triggered Abortion is Mediated by Increase of CD8+ TNF‐α+ Decidual Cells via Substance P

Diabetes teratogenicity in mice is accompanied with distorted expression of TGF‐β2 in the uterus

Effects Of Tachykinins On Uterine Smooth Muscle

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Murine Stress‐triggered Abortion is Mediated by Increase of CD8⁺ TNF‐α⁺ Decidual Cells via Substance P

Murine Stress‐triggered Abortion is Mediated by Increase of CD8⁺ TNF‐α⁺ Decidual Cells via Substance P