Stress ulcer accompanying subarachnoid hemorrhage—A new rat model

Tsuchiya, Juji; Ito, Yoshiaki; Hino, Teruo; Ohashi, Hirofumi; Kunieda, T; Sakata, Kazuki

doi:10.1007/bf02469522

Cited by 5 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another retrospective analysis of 16,672 stroke patients identified only 17 patients with clinically significant GI hemorrhage, none of whom had a SAH [46]. Experimental models of SAH show stressrelated mucosal disease, but direct correlation with human data is lacking [48,49].…”

Section: Subarachnoid Hemorrhagementioning

confidence: 99%

Gastrointestinal Prophylaxis in Neurocritical Care

et al. 2011

View full text Add to dashboard Cite

The aim of this study is to review and summarize the relevant literature regarding pharmacologic and non-pharmacologic methods of prophylaxis against gastrointestinal (GI) stress ulceration, and upper gastrointestinal bleeding in critically ill patients. Stress ulcers are a known complication of a variety of critical illnesses. The literature regarding epidemiology and management of stress ulcers and complications thereof, is vast and mostly encompasses patients in medical and surgical intensive care units. This article aims to extrapolate meaningful data for use with a population of critically ill neurologic and neurosurgical patients in the neurological intensive care unit setting. Studies were identified from the Cochrane Central Register of controlled trials and NLM PubMed for English articles dealing with an adult population. We also scanned bibliographies of relevant studies. The results show that H(2)A, sucralfate, and PPI all reduce the incidence of UGIB in neurocritically ill patients, but H(2)A blockers may cause encephalopathy and interact with anticonvulsant drugs, and have been associated with higher rates of nosocomial pneumonias, but causation remains unproven and controversial. For these reasons, we advocate against routine use of H(2)A for GI prophylaxis in neurocritical patients. There is a paucity of high-level evidence studies that apply to the neurocritical care population. From this study, it is concluded that stress ulcer prophylaxis among critically ill neurologic and neurosurgical patients is important in preventing ulcer-related GI hemorrhage that contributes to both morbidity and mortality. Further, prospective trials are needed to elucidate which methods of prophylaxis are most appropriate and efficacious for specific illnesses in this population.

show abstract

Section: Subarachnoid Hemorrhagementioning

confidence: 99%

Gastrointestinal Prophylaxis in Neurocritical Care

et al. 2011

View full text Add to dashboard Cite

show abstract

Spontaneous Subarachnoid Hemorrhage and the First Week After Aneurysmal Subarachnoid Hemorrhage

McElenney

Schreiber

Georges

et al. 2021

Neurocritical Care for Neurosurgeons

View full text Add to dashboard Cite

Neurogenic stress ulceration caused by laparatomy under anesthesia plus restraint. The device of a new rat model

Yoshida

Saji

Sakata

1990

The Japanese Journal of Surgery

View full text Add to dashboard Cite

We report herein, a new method devised of producing neurogenic stress ulceration in rats. An experimental subarachnoid hemorrhage (SAH) was produced in rats by injecting 0.2 ml of arterial blood from other rats into the cisterna magna. Three days later, the rats were laparotomized for 1 hour under ether anesthesia, followed by restraint for 3 hours in wakefulness. The SAH rats were found to develop stress ulcers (UL-I) in the glandular stomach, which were significantly (p less than 0.001) more marked than those in non-SAH rats. Measurements were performed on gastric acid secretion, an important aggressive factor. It was found that the SAH rats undergoing the laparotomy-restraint stress showed a more marked increase in gastric acid secretion and a more marked reduction in MBF, than the non-SAH rats. The effects of bilateral vagotomy, upper abdominal sympathectomy and bilateral adrenalectomy were examined, and it was revealed that the SAH rats were under the condition of hyperreactivity both in the sympathetic and parasympathetic systems and, on this basis, the laparotomy-restraint stress caused the stress gastric ulceration. In this rat model, the laparotomy stress was applied under anesthesia and any exposure to low temperatures which may have interfered with blood circulation was avoided.

show abstract

Stress ulcer accompanying subarachnoid hemorrhage—A new rat model

Cited by 5 publications

References 7 publications

Gastrointestinal Prophylaxis in Neurocritical Care

Gastrointestinal Prophylaxis in Neurocritical Care

Spontaneous Subarachnoid Hemorrhage and the First Week After Aneurysmal Subarachnoid Hemorrhage

Neurogenic stress ulceration caused by laparatomy under anesthesia plus restraint. The device of a new rat model

Contact Info

Product

Resources

About