Stress ulcer prophylaxis in the postoperative period

Allen, Michelle E; Kopp, Brian J.; Erstad, Brian L.

doi:10.1093/ajhp/61.6.588

Cited by 54 publications

(26 citation statements)

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“…In a large, prospective multicenter cohort study of over 2,000 patients, only two strong independent risk factors for clinically important bleeding emerged: mechanical ventilation and coagulopathy [30]. The American Society of Health-Service Pharmacists (ASHP) recently published guidelines on stress ulcer prophylaxis in the postoperative period to augment their previously published guidelines in 1999 [31,32]. The guidelines suggest the majority of recently published prospective studies and a meta-analysis have been unable to demonstrate a reduction in clinically important bleeding with pharmacologic agents.…”

Section: Discussionmentioning

confidence: 99%

Intravenous pantoprazole utilization in a level 1 trauma center

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Intravenous pantoprazole utilization in a level 1 trauma center

et al. 2007

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“…Vulnerable patients have a previous history of ulceration, renal failure, sepsis, MODS, mechanical ventilation, coagulopathy and burns [98]. Prophylaxis should be done by administration of cytoprotective agents (sucralfate), H2-receptor blockers (ranitidine) or proton-pump inhibitors and early intragastric enteric nutrition [99].…”

Section: Abdominal Injurymentioning

confidence: 99%

Surgical intensive care unit—the trauma surgery perspective

Kleber

Schaser

Haas

2011

Langenbecks Arch Surg

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“…The administration of acidsuppressing medications such as histamine-2 receptor antagonists, proton-pump inhibitors, and sucralfate has been shown to decrease the risk of stress-related gastrointestinal bleeding in critically ill patients [41][42][43]. Currently, the frequency of clinically important bleeding is low and the majority of recently published prospective studies and meta-analyses have found little significant reduction in bleeding with pharmacologic prophylaxis [42,44], although stress ulcer prophylaxis is probably beneficial in selected patients in the intensive care unit (ICU) [8].…”

Section: Stress-related Mucosal Damage In Critically Ill Patientsmentioning

confidence: 99%

Epidemiology and Clinical Presentation of Stress-Related Peptic Damage and Chronic Peptic Ulcer

Choung¹,

Talley²

2008

CMM

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Stress is often considered a risk factor for upper gastrointestinal tract disease, as any acute threat to homeostasis evokes an adaptive or allostatic response. Various types of stress may play a role in the onset and modulation of acute or chronic peptic ulcer disease. When upper endoscopy is employed, stress-related acute mucosal damage is found to develop shortly after admission to an intensive care unit in 60 to 100 percent of patients. However, the epidemiology of chronic peptic damage has not been accurately described by type of stressor, and any association is controversial. The incidence of chronic peptic ulcer disease is falling; the proportion of chronic peptic ulcers that are Helicobacter pylori negative appears to be between 5% and 20%, and some have suggested that stress or other psychological factors may play a role here. Therefore, our objective is to provide an overview of the epidemiology and clinical presentation of stress-related peptic damage, in order to shed insights into the current understanding of the pathophysiology and treatment.

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Stress ulcer prophylaxis in the postoperative period

Cited by 54 publications

References 0 publications

Intravenous pantoprazole utilization in a level 1 trauma center

Intravenous pantoprazole utilization in a level 1 trauma center

Surgical intensive care unit—the trauma surgery perspective

Epidemiology and Clinical Presentation of Stress-Related Peptic Damage and Chronic Peptic Ulcer

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