Stressed degradation studies of domiphen bromide by LC-ESI-MS/MS identify a novel promising antimicrobial agent

Fumagalli, Laura; Regazzoni, Luca; Straniero, Valentina; Valoti, Ermanno; Aldini, Giancarlo; Vistoli, Giulio; Picozzi, Claudia

doi:10.1016/j.jpba.2018.06.055

Cited by 11 publications

(16 citation statements)

References 12 publications

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“… In this data article, HPLC analyses were applied to investigate the hydrolytic and thermal stability of domiphen bromide a FDA approved OTC ingredients endowed with antimicrobial activity. The data obtained by stressing domiphen bromide in acid, base and thermal conditions enlarge the research article published by Fumagalli et al [ 2 ]. The chromatograms herein presented reveal that domiphen bromide is stable under acidic and thermal stress while the treatment with base yield to a by-product.…”

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confidence: 68%

Data on thermal and hydrolytic stability of both domiphen bromide and para-bromodomiphen bromide

et al. 2018

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In this data article, HPLC analyses were applied to investigate the hydrolytic and thermal stability of domiphen bromide a FDA approved OTC ingredients endowed with antimicrobial activity. The data obtained by stressing domiphen bromide in acid, base and thermal conditions enlarge the research article published by Fumagalli et al. [2]. The chromatograms herein presented reveal that domiphen bromide is stable under acidic and thermal stress while the treatment with base yield to a by-product. The para-bromo derivative, p-bromodomiphen bromide shows the same behavior under the up mentioned stressed conditions.

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confidence: 68%

Data on thermal and hydrolytic stability of both domiphen bromide and para-bromodomiphen bromide

et al. 2018

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“…Various diseases caused by pathogens are difficult to treat and inappropriate use of antimicrobial drugs may cause acquired drug resistance, which seriously endangers public health and environmental safety. 16 The current study found that, after AgNPs or domiphen being used alone, it produced antimicrobial activity against common pathogens ( Acinetobacter baumannii, Staphylococcus aureus, Escherichia coli , and Candida albicans ). However, when drugs used in combination, they could play synergistic antimicrobial effects.…”

Section: Discussionmentioning

confidence: 63%

“… 14 , 15 Notably, the large-amount use of AgNPs may cause sedimentation and aggregation, which then reduces their antimicrobials effects. In contrast, as a cationic surfactant, domiphen exerts broad-spectrum antimicrobials effects, inhibit microbial growth at a low concentration, 16 and fully disperses AgNPs. The combined use of both drugs may produce synergistic effects, and act as a new strategy for the selection of antimicrobial drugs and clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

Combination of AgNPs and Domiphen is Antimicrobial Against Biofilms of Common Pathogens

Hu¹,

Yang²,

Yin³

et al. 2021

IJN

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Purpose The aim was to evaluate the antimicrobial potential of AgNPs synthesized with Artemisia argyi leaf extract and investigate the antimicrobial synergistic effects of AgNPs combined with domiphen and provide an efficient and broad-spectrum combination drug strategy. Methods AgNPs synthesized with Artemisia argyi leaf extract were studied using UV–vis spectroscopy, FTIR spectroscopy and particle size analysis. Then, Artemisia argyi leaf extract-synthesized AgNPs and domiphen were tested against Acinetobacter baumannii (ATCC 19606), Staphylococcus aureus (ATCC 6538), Escherichia coli (8099) and Candida albicans (ATCC 10231), respectively. Then, we explore synergistic antimicrobial effect and synergistic anti-biofilm effect through combined drug susceptibility test and combined drug minimum biofilm eradication concentration (MBEC 50 ) test. Results Characteristic absorption bands of AgNPs were found near 430 nm in the UV–vis spectrum. Particle size analysis results revealed that the average particle size of Artemisia argyi leaf extract-synthesized AgNPs was 77.6 nm. Artemisia argyi leaf extract-synthesized AgNPs showed high antimicrobial activity against the above four strains. Minimum inhibitory concentration (MIC) of Artemisia argyi leaf extract-synthesized AgNPs against strains was 1 μg/mL for Acinetobacter baumannii , 2 μg/mL for Staphylococcus aureus, Escherichia coli and Candida albicans . MBEC 50 of Artemisia argyi leaf extract-synthesized AgNPs against strains was 2 μg/mL for Acinetobacter baumannii , 4 μg/mL for Staphylococcus aureus , 1/2 μg/mL for Escherichia coli and 2 μg/mL for Candida albicans . The combination of Artemisia argyi leaf extract-synthesized AgNPs and domiphen has synergistic antimicrobial effect and synergistic anti-biofilm effect. Fractional inhibitory concentration (FIC) was ≤0.5. Conclusion Artemisia argyi leaf extract-synthesized AgNPs had antimicrobial activity against the above four strains. The combination of Artemisia argyi leaf extract-synthesized AgNPs and domiphen has synergistic antimicrobial effects to reduce the dosage of each antimicrobial drugs. Artemisia argyi leaf extract-synthesized AgNPs and domiphen have synergistic anti-biofilm effects.

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“…Demand for these disinfectant agents has increased over the decades, furthermore, their use is not only limited as a germicidal, but they have been widely used also in a variety of industrial, agricultural, clinical applications, and consumer products [ 78 , 79 , 80 , 81 ].…”

Section: Most Common Antimicrobial Classesmentioning

confidence: 99%

Back to Basics: Choosing the Appropriate Surface Disinfectant

Artasensi

Fumagalli

2021

Antibiotics

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From viruses to bacteria, our lives are filled with exposure to germs. In built environments, exposure to infectious microorganisms and their byproducts is clearly linked to human health. In the last year, public health emergency surrounding the COVID-19 pandemic stressed the importance of having good biosafety measures and practices. To prevent infection from spreading and to maintain the barrier, disinfection and hygiene habits are crucial, especially when the microorganism can persist and survive on surfaces. Contaminated surfaces are called fomites and on them, microorganisms can survive even for months. As a consequence, fomites serve as a second reservoir and transfer pathogens between hosts. The knowledge of microorganisms, type of surface, and antimicrobial agent is fundamental to develop the best approach to sanitize fomites and to obtain good disinfection levels. Hence, this review has the purpose to briefly describe the organisms, the kind of risk associated with them, and the main classes of antimicrobials for surfaces, to help choose the right approach to prevent exposure to pathogens.

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Stressed degradation studies of domiphen bromide by LC-ESI-MS/MS identify a novel promising antimicrobial agent

Cited by 11 publications

References 12 publications

Data on thermal and hydrolytic stability of both domiphen bromide and para-bromodomiphen bromide

Data on thermal and hydrolytic stability of both domiphen bromide and para-bromodomiphen bromide

Combination of AgNPs and Domiphen is Antimicrobial Against Biofilms of Common Pathogens

Back to Basics: Choosing the Appropriate Surface Disinfectant

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